Search Results - "Mohamed, Mamdouh F.A."

Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety by Al-Sanea, Mohammad M, Gotina, Lizaveta, Mohamed, Mamdouh Fa, Grace Thomas Parambi, Della, Gomaa, Hesham A M, Mathew, Bijo, Youssif, Bahaa G M, Alharbi, Khalid Saad, Elsayed, Zainab M, Abdelgawad, Mohamed A, Eldehna, Wagdy M

“…Histone deacetylases (HDACs) represent one of the most validated cancer targets. The inhibition of HDACs has been proven to be a successful strategy for the…”
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EGFR inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and docking studies of novel xanthine derivatives carrying chalcone moiety as hybrid molecules by Abou-Zied, Hesham A., Youssif, Bahaa G.M., Mohamed, Mamdouh F.A., Hayallah, Alaa M., Abdel-Aziz, Mohamed

“…[Display omitted] •A series of 20 novel compounds contain xanthine-chalcone hybrid was designed and synthesized.•The synthesized hybrids were evaluated against…”
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Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production by Youssif, Bahaa G.M., Abdelrahman, Mostafa H., Abdelazeem, Ahmed H., abdelgawad, Mohamed A., Ibrahim, Hussein M., Salem, Ola I.A., Mohamed, Mamdouh F.A., Treambleau, Laurent, Bukhari, Syed Nasir Abbas

“…A series of novel compounds carrying pyrazino[1,2-a]indol-1(2H)-one scaffold (5a-g) and their reaction intermediates, indole-2-carboxamides, (3a-g) were…”
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Utilization of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinone as a cap moiety in design of novel histone deacetylase inhibitors by Mohamed, Mamdouh F.A., Youssif, Bahaa G.M., Shaykoon, Montaser Sh. A., Abdelrahman, Mostafa H., Elsadek, Bakheet E.M., Aboraia, Ahmed S., Abuo-Rahma, Gamal El-Din A.

“…[Display omitted] •12 novel compounds contain Tetrahydrobenzo[4,5]Thieno[2,3-d]pyrimidinone as a novel cap group, attached to ZBG via aliphatic, aralkyl or…”
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Molecular targets and anticancer activity of quinoline-chalcone hybrids: literature review by Mohamed, Mamdouh F. A, Abuo-Rahma, Gamal El-Din A

“…α,β-Unsaturated chalcone moieties and quinoline scaffolds play an important role in medicinal chemistry, especially in the identification and development of…”
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Comprehensive review for anticancer hybridized multitargeting HDAC inhibitors by Bass, Amr K.A., El-Zoghbi, Mona S., Nageeb, El-Shimaa M., Mohamed, Mamdouh F.A., Badr, Mohamed, Abuo-Rahma, Gamal El-Din A.

“…Despite the encouraging clinical progress of chemotherapeutic agents in cancer treatment, innovation and development of new effective anticancer candidates…”
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Novel quinoxaline derivatives as dual EGFR and COX-2 inhibitors: synthesis, molecular docking and biological evaluation as potential anticancer and anti-inflammatory agents by Ahmed, Eman A, Mohamed, Mamdouh F. A, Omran, Omran A

“…Novel quinoxaline derivatives ( 2a-d , 3 , 4a , 4b and 5-15 ) have been synthesized via the reaction of 4-methyl-3-oxo-3,4-dihydroquinoxaline-2-carbohydrazide…”
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Targeting endoplasmic reticulum stress, Nrf-2/HO-1, and NF-κB by myristicin and its role in attenuation of ulcerative colitis in rats by Ismail Abo El-Fadl, Huda M., Mohamed, Mamdouh F.A.

“…Ulcerative colitis (UC) is characterized by the up-regulation of pro-inflammatory mediators, apoptotic signals, and oxidative stress that can lead to an…”
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Synthesis, Antimicrobial, Anti-Virulence and Anticancer Evaluation of New 5(4 H )-Oxazolone-Based Sulfonamides by Almalki, Ahmad J, Ibrahim, Tarek S, Taher, Ehab S, Mohamed, Mamdouh F A, Youns, Mahmoud, Hegazy, Wael A H, Al-Mahmoudy, Amany M M

“…Since the synthesis of prontosil the first prodrug shares their chemical moiety, sulfonamides exhibit diverse modes of actions to serve as antimicrobials,…”
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Synthesis, EGFR-TK inhibition and anticancer activity of new quinoxaline derivatives by Ahmed, Eman A., Mohamed, Mamdouh F. A., Omran, Ahmed, Salah, Hanan

“…Ethyl 4-substituted-3-oxo-quinoxaline-2-carboxylates 3-5 were obtained via alkylation of ethyl 3-oxo-3,4-dihydroquinoxaline-2-carboxylate (1). Compound 1 was…”
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Design, synthesis and preliminary antibacterial evaluation of novel 1,3-benzoxazole/carboximidamide- and 1,3-benzoxazole/3-aryl-1,2,4-oxadiazole hybrids by Alsimaree, Abdulrahman A., Sharaf, Mohamed, Moustafa, Amr H., Abd-El-Aziz, Ahmad, Mohamed, Mounir A.A., Malik, M. Shaheer, Obaid, Rami J., Moussa, Ziad, Mohamed, Mamdouh F.A., Omran, Omran A., Ahmed, Saleh A.

“…•Novel benzoxazole/carboximidamide hybrids were prepared.•Another 1,3-benzoxazole/3-aryl-1,2,4-oxadiazole hybrid series was designed.•Intramolecular…”
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Design, synthesis, and antibacterial evaluation of new quinoline-1,3,4-oxadiazole and quinoline-1,2,4-triazole hybrids as potential inhibitors of DNA gyrase and topoisomerase IV by Hofny, Heba A., Mohamed, Mamdouh F.A., Gomaa, Hesham A.M., Abdel-Aziz, Salah A., Youssif, Bahaa G.M., El-koussi, Nawal A., Aboraia, Ahmed S.

“…[Display omitted] •A series of novel quinoline-1,3,4-oxadiazole and quinoline-1,2,4-triazole hybrids has been designed and synthesized.•The new hybrids were…”
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Chemistry and Applications of Functionalized 2,4‐Thiazolidinediones by Ibrahim, Ayman M., Shoman, Mai E., Mohamed, Mamdouh F. A., Hayallah, Alaa M., El‐Din A. Abuo‐Rahma, Gamal

“…Thiazolidinedione (TZD) is one of the privileged heterocyclic rings and has shown many biological applications in medicinal chemistry and drug discovery. This…”
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Potential repurposed SARS-CoV-2 (COVID-19) infection drugs by Abuo-Rahma, Gamal El-Din A, Mohamed, Mamdouh F. A, Ibrahim, Tarek S, Shoman, Mai E, Samir, Ebtihal, Abd El-Baky, Rehab M

“…The global outbreak of COVID-19 viral infection is associated with the absence of specific drug(s) for fighting this viral infection. About 10 million people…”
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Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors by Mohamed, Mamdouh F.A., Marzouk, Adel A., Nafady, Ayman, El-Gamal, Dalia A., Allam, Rasha M., Abuo-Rahma, Gamal El-Din A., El Subbagh, Hussein I., Moustafa, Amr H.

“…[Display omitted] •A novel series of aryl carboximidamides 4a-g and their cyclized 3-aryl-1,2,4-oxadiazoles 5a-g counterparts derived from indomethacin 1 were…”
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Design, synthesis, and molecular docking of novel pyrazole-chalcone analogs of lonazolac as 5-LOX, iNOS and tubulin polymerization inhibitors with potential anticancer and anti-inflammatory activities by Ahmed, Asmaa H.H., Mohamed, Mamdouh F.A., Allam, Rasha M., Nafady, Ayman, Mohamed, Shaaban K., Gouda, Ahmed E., Beshr, Eman A.M.

“…[Display omitted] •A novel series of pyrazole-chalcone analogues of lonazolac (7a-g and 8a-g) and screened for their in vitro anticancer activity.•Hybrid 8g…”
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Optimization of the synthesis of het/aryl-amidoximes using an efficient green chemistry by Albayati, Mustafa R., Mohamed, Mamdouh F. A., Moustafa, Amr H.

“…This work focuses on optimizing an efficient green synthesis of arylamidoximes from appropriate nitrile and hydroxylamine hydrochloride in water and…”
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Novel pyrrol-2(3H)-ones and pyridazin-3(2H)-ones carrying quinoline scaffold as anti-proliferative tubulin polymerization inhibitors by Abdelbaset, Mahmoud S., Abuo-Rahma, Gamal El-Din A., Abdelrahman, Mostafa H., Ramadan, Mohamed, Youssif, Bahaa G.M., Bukhari, Syed Nasir Abbas, Mohamed, Mamdouh F.A., Abdel-Aziz, Mohamed

“…[Display omitted] •Novel quinolinyl pyrrolone and quinolinyl pyridazinone derivatives.•Antiproliferative activity.•BRAF kinase inhibition.•Tubulin…”
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Utilization of cyanopyridine in design and synthesis of first-in-class anticancer dual acting PIM-1 kinase/HDAC inhibitors by Bass, Amr K.A., Nageeb, El-Shimaa M., El-Zoghbi, Mona S., Mohamed, Mamdouh F.A., Badr, Mohamed, Abuo-Rahma, Gamal El-Din A.

“…[Display omitted] •Twenty-one cyanopyridine derivatives were designed as PIM-1/HDAC inhibitors.•3b, 3c, 4d, 4e, 4b and 4g showed the most active activity…”
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Synthesis, antimicrobial studies, and molecular docking of some new dihydro-1,3,4-thiadiazole and pyrazole derivatives derived from dithiocarbazates by Moustafa, Amr Hassan, Ahmed, Doaa H., El-Wassimy, Mohamed T. M., Mohamed, Mamdouh F. A.

“…A series of 3-acetyl-2-aryl-5-methylthio-2,3-dihydro-1,3,4-thiadiazoles 3a-g, N- (4-acetyl-5-aryl-4,5-dihydro-1,3,4-thiadiazol-2-yl) acetamide derivatives 5a-e…”
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