Search Results - "Mohamed, Mamdouh F. A"

Molecular targets and anticancer activity of quinoline-chalcone hybrids: literature review by Mohamed, Mamdouh F. A, Abuo-Rahma, Gamal El-Din A

“…α,β-Unsaturated chalcone moieties and quinoline scaffolds play an important role in medicinal chemistry, especially in the identification and development of…”
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Novel quinoxaline derivatives as dual EGFR and COX-2 inhibitors: synthesis, molecular docking and biological evaluation as potential anticancer and anti-inflammatory agents by Ahmed, Eman A, Mohamed, Mamdouh F. A, Omran, Omran A

“…Novel quinoxaline derivatives ( 2a-d , 3 , 4a , 4b and 5-15 ) have been synthesized via the reaction of 4-methyl-3-oxo-3,4-dihydroquinoxaline-2-carbohydrazide…”
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Synthesis, Antimicrobial, Anti-Virulence and Anticancer Evaluation of New 5(4 H )-Oxazolone-Based Sulfonamides by Almalki, Ahmad J, Ibrahim, Tarek S, Taher, Ehab S, Mohamed, Mamdouh F A, Youns, Mahmoud, Hegazy, Wael A H, Al-Mahmoudy, Amany M M

“…Since the synthesis of prontosil the first prodrug shares their chemical moiety, sulfonamides exhibit diverse modes of actions to serve as antimicrobials,…”
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Potential repurposed SARS-CoV-2 (COVID-19) infection drugs by Abuo-Rahma, Gamal El-Din A, Mohamed, Mamdouh F. A, Ibrahim, Tarek S, Shoman, Mai E, Samir, Ebtihal, Abd El-Baky, Rehab M

“…The global outbreak of COVID-19 viral infection is associated with the absence of specific drug(s) for fighting this viral infection. About 10 million people…”
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Design, Synthesis, In Vitro Anticancer Evaluation and Molecular Modelling Studies of 3,4,5-Trimethoxyphenyl-Based Derivatives as Dual EGFR/HDAC Hybrid Inhibitors by Ibrahim, Tarek S, Malebari, Azizah M, Mohamed, Mamdouh F A

“…Recently, combining histone deacetylase (HDAC) inhibitors with chemotherapeutic drugs or agents, in particular epidermal growth factor receptor (EGFR)…”
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Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis, molecular docking studies and ADMET prediction by Ibrahim, Tarek S., Moustafa, Amr H., Almalki, Ahmad J., Allam, Rasha M., Althagafi, Abdulhamid, Md, Shadab, Mohamed, Mamdouh F. A.

“…Two series of chalcone/aryl carboximidamide hybrids 4a-f and 6a-f were synthesised and evaluated for their inhibitory activity against iNOS and PGE2. The most…”
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Isolation and characterization of novel acetylcholinesterase inhibitors from Ficus benghalensis L. leaves by Hassan, Heba Ali, Allam, Ahmed E, Abu-Baih, Dalia H, Mohamed, Mamdouh F A, Abdelmohsen, Usama Ramadan, Shimizu, Kuniyoshi, Desoukey, Samar Y, Hayallah, Alaa M, Elrehany, Mahmoud A, Mohamed, Khaled M, Kamel, Mohamed S

“…Metabolic profiling of the crude methanolic extract of leaves has revealed the presence of different phenolic and nitrogenous compounds including cerebrosides…”
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Targeting 3CLpro and SARS-CoV-2 RdRp by Amphimedon sp. Metabolites: A Computational Study by Shady, Nourhan Hisham, Hayallah, Alaa M, Mohamed, Mamdouh F A, Ghoneim, Mohammed M, Chilingaryan, Garri, Al-Sanea, Mohammad M, Fouad, Mostafa A, Kamel, Mohamed Salah, Abdelmohsen, Usama Ramadan

“…Since December 2019, novel coronavirus disease 2019 (COVID-19) pandemic has caused tremendous economic loss and serious health problems worldwide. In this…”
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Not Only Antimicrobial: Metronidazole Mitigates the Virulence of Proteus mirabilis Isolated from Macerated Diabetic Foot Ulcer by Khayyat, Ahdab N., Abbas, Hisham A., Mohamed, Mamdouh F. A., Asfour, Hani Z., Khayat, Maan T., Ibrahim, Tarek S., Youns, Mahmoud, Khafagy, El-Sayed, Abu Lila, Amr S., Safo, Martin K., Hegazy, Wael A. H.

“…Diabetic foot ulcers are recognized to be a severe complication of diabetes, increasing the risk of amputation and death. The bacterial infection of Diabetic…”
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In Vitro Antimycobacterial Activity and Physicochemical Characterization of Diaryl Ether Triclosan Analogues as Potential InhA Reductase Inhibitors by Ibrahim, Tarek S, Taher, Ehab S, Samir, Ebtihal, M Malebari, Azizah, Khayyat, Ahdab N, Mohamed, Mamdouh F A, Bokhtia, Riham M, AlAwadh, Mohammed A, Seliem, Israa A, Asfour, Hani Z, Alhakamy, Nabil A, Panda, Siva S, Al-Mahmoudy, Amany M M

“…Two sets of diphenyl ether derivatives incorporating five-membered 1,3,4-oxadiazoles, and their open-chain aryl hydrazone analogs were synthesized in good…”
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Comprehensive review for anticancer hybridized multitargeting HDAC inhibitors by Bass, Amr K.A., El-Zoghbi, Mona S., Nageeb, El-Shimaa M., Mohamed, Mamdouh F.A., Badr, Mohamed, Abuo-Rahma, Gamal El-Din A.

“…Despite the encouraging clinical progress of chemotherapeutic agents in cancer treatment, innovation and development of new effective anticancer candidates…”
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EGFR inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and docking studies of novel xanthine derivatives carrying chalcone moiety as hybrid molecules by Abou-Zied, Hesham A., Youssif, Bahaa G.M., Mohamed, Mamdouh F.A., Hayallah, Alaa M., Abdel-Aziz, Mohamed

“…[Display omitted] •A series of 20 novel compounds contain xanthine-chalcone hybrid was designed and synthesized.•The synthesized hybrids were evaluated against…”
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Targeting endoplasmic reticulum stress, Nrf-2/HO-1, and NF-κB by myristicin and its role in attenuation of ulcerative colitis in rats by Ismail Abo El-Fadl, Huda M., Mohamed, Mamdouh F.A.

“…Ulcerative colitis (UC) is characterized by the up-regulation of pro-inflammatory mediators, apoptotic signals, and oxidative stress that can lead to an…”
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Synthesis, EGFR-TK inhibition and anticancer activity of new quinoxaline derivatives by Ahmed, Eman A., Mohamed, Mamdouh F. A., Omran, Ahmed, Salah, Hanan

“…Ethyl 4-substituted-3-oxo-quinoxaline-2-carboxylates 3-5 were obtained via alkylation of ethyl 3-oxo-3,4-dihydroquinoxaline-2-carboxylate (1). Compound 1 was…”
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Design, synthesis, and antibacterial evaluation of new quinoline-1,3,4-oxadiazole and quinoline-1,2,4-triazole hybrids as potential inhibitors of DNA gyrase and topoisomerase IV by Hofny, Heba A., Mohamed, Mamdouh F.A., Gomaa, Hesham A.M., Abdel-Aziz, Salah A., Youssif, Bahaa G.M., El-koussi, Nawal A., Aboraia, Ahmed S.

“…[Display omitted] •A series of novel quinoline-1,3,4-oxadiazole and quinoline-1,2,4-triazole hybrids has been designed and synthesized.•The new hybrids were…”
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Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production by Youssif, Bahaa G.M., Abdelrahman, Mostafa H., Abdelazeem, Ahmed H., abdelgawad, Mohamed A., Ibrahim, Hussein M., Salem, Ola I.A., Mohamed, Mamdouh F.A., Treambleau, Laurent, Bukhari, Syed Nasir Abbas

“…A series of novel compounds carrying pyrazino[1,2-a]indol-1(2H)-one scaffold (5a-g) and their reaction intermediates, indole-2-carboxamides, (3a-g) were…”
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Chemistry and Applications of Functionalized 2,4‐Thiazolidinediones by Ibrahim, Ayman M., Shoman, Mai E., Mohamed, Mamdouh F. A., Hayallah, Alaa M., El‐Din A. Abuo‐Rahma, Gamal

“…Thiazolidinedione (TZD) is one of the privileged heterocyclic rings and has shown many biological applications in medicinal chemistry and drug discovery. This…”
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Design, synthesis, and anti-breast cancer activity evaluation of novel 3-cyanopyridine derivatives as PIM-1 inhibitors by Hussein, Bahgat R. M., Mohammed, Hayam H., Ahmed, Eman A., Alshazly, Omar, Mohamed, Mamdouh F. A., Omran, Omran A.

“…Abstract A novel series of cyanopyridines 7a-j were synthesized via a one-pot multicomponent reaction of arylidene 4 with ammonium acetate 5 and respective…”
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Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors by Mohamed, Mamdouh F.A., Marzouk, Adel A., Nafady, Ayman, El-Gamal, Dalia A., Allam, Rasha M., Abuo-Rahma, Gamal El-Din A., El Subbagh, Hussein I., Moustafa, Amr H.

“…[Display omitted] •A novel series of aryl carboximidamides 4a-g and their cyclized 3-aryl-1,2,4-oxadiazoles 5a-g counterparts derived from indomethacin 1 were…”
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Design, synthesis, and molecular docking of novel pyrazole-chalcone analogs of lonazolac as 5-LOX, iNOS and tubulin polymerization inhibitors with potential anticancer and anti-inflammatory activities by Ahmed, Asmaa H.H., Mohamed, Mamdouh F.A., Allam, Rasha M., Nafady, Ayman, Mohamed, Shaaban K., Gouda, Ahmed E., Beshr, Eman A.M.

“…[Display omitted] •A novel series of pyrazole-chalcone analogues of lonazolac (7a-g and 8a-g) and screened for their in vitro anticancer activity.•Hybrid 8g…”
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