Search Results - "Mogi, Chihiro"

Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis by Haraoka, Yukinari, Akieda, Yuki, Nagai, Yuri, Mogi, Chihiro, Ishitani, Tohru

“…Most tumours are thought to arise through oncogenic cell generation followed by additional mutations. How a new oncogenic cell primes tumorigenesis by…”
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A missense mutation of Leu74Pro of OGR1 found in familial amelogenesis imperfecta actually causes the loss of the pH-sensing mechanism by Sato, Koichi, Mogi, Chihiro, Mighell, Alan J., Okajima, Fumikazu

“…Ovarian cancer G protein-coupled receptor 1 (OGR1), also known as GPR68, is a proton-sensing G protein-coupled receptor (GPCR) coupling to Gq/11/phospholipase…”
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Alamandine reduces leptin expression through the c-Src/p38 MAP kinase pathway in adipose tissue by Uchiyama, Tsuyoshi, Okajima, Fumikazu, Mogi, Chihiro, Tobo, Ayaka, Tomono, Shoichi, Sato, Koichi

“…Obesity is associated with an increased risk of diabetes mellitus, hypertension, and renal dysfunction. Angiotensin 1-7 and alamandine are heptameric renin…”
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Rapid reverse genetics systems for Nothobranchius furzeri, a suitable model organism to study vertebrate aging by Oginuma, Masayuki, Nishida, Moana, Ohmura-Adachi, Tomomi, Abe, Kota, Ogamino, Shohei, Mogi, Chihiro, Matsui, Hideaki, Ishitani, Tohru

“…The African turquoise killifish Nothobranchius furzeri ( N. furzeri ) is a useful model organism for studying aging, age-related diseases, and embryonic…”
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The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model by Sato, Koichi, Tobo, Ayaka, Mogi, Chihiro, Tobo, Masayuki, Yamane, Nobuhiro, Tosaka, Masahiko, Tomura, Hideaki, Im, Dong-Soon, Okajima, Fumikazu

“…Extracellular acidification in the brain has been observed in ischemia; however, the physiological and pathophysiological implications of the pH reduction…”
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Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells by MUSHA, Shiori, YOSHIDA, Saishu, MURAKAMI, Syo, KOJIMA, Ryotaro, DEAI, Masahito, SASO, Naoshi, MOGI, Chihiro, SATO, Koichi, OKAJIMA, Fumikazu, TOMURA, Hideaki

“…Hormone-secreting pituitary adenomas show unregulated hormonal hypersecretion and cause hyperpituitarism. However, the mechanism of the unregulated hormone…”
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The proton-sensing G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) shows cardioprotective effects against myocardial infarction by Nagasaka, Akiomi, Mogi, Chihiro, Ono, Hiroki, Nishi, Toshihide, Horii, Yuma, Ohba, Yuki, Sato, Koichi, Nakaya, Michio, Okajima, Fumikazu, Kurose, Hitoshi

“…Myocardial infarction (MI) is an ischaemic heart condition caused by the occlusion of coronary arteries. Following MI, lactic acid from anaerobic glycolysis…”
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Ionotropic and Metabotropic Proton-Sensing Receptors Involved in Airway Inflammation in Allergic Asthma by Aoki, Haruka, Okajima, Fumikazu, Mogi, Chihiro

“…An acidic microenvironment has been shown to evoke a variety of airway responses, including cough, bronchoconstriction, airway hyperresponsiveness (AHR),…”
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Involvement of Proton-Sensing TDAG8 in Extracellular Acidification-Induced Inhibition of Proinflammatory Cytokine Production in Peritoneal Macrophages by Mogi, Chihiro, Tobo, Masayuki, Tomura, Hideaki, Murata, Naoya, He, Xiao-dong, Sato, Koichi, Kimura, Takao, Ishizuka, Tamotsu, Sasaki, Takehiko, Sato, Takashi, Kihara, Yasuyuki, Ishii, Satoshi, Harada, Akihiro, Okajima, Fumikazu

“…Extracellular acidification inhibited LPS-induced TNF-alpha protein production, which was associated with an inhibition of TNF-alpha mRNA expression, in mouse…”
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Critical role of ABCA1 transporter in sphingosine 1‐phosphate release from astrocytes by Sato, Koichi, Malchinkhuu, Enkhzol, Horiuchi, Yuta, Mogi, Chihiro, Tomura, Hideaki, Tosaka, Masahiko, Yoshimoto, Yuhei, Kuwabara, Atsushi, Okajima, Fumikazu

“…Sphingosine 1‐phosphate (S1P) is accumulated in lipoproteins, especially high‐density lipoprotein (HDL), in plasma. However, it remains uncharacterized how…”
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Role of extracellular proton-sensing OGR1 in regulation of insulin secretion and pancreatic β-cell functions by Mogi, Chihiro, Nakakura, Takashi, Okajima, Fumikazu

“…Insulin secretion with respect to pH environments has been investigated for a long time but its mechanism remains largely unknown. Extracellular pH is usually…”
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Mutations in the pH-Sensing G-protein-Coupled Receptor GPR68 Cause Amelogenesis Imperfecta by Parry, David A., Smith, Claire E.L., El-Sayed, Walid, Poulter, James A., Shore, Roger C., Logan, Clare V., Mogi, Chihiro, Sato, Koichi, Okajima, Fumikazu, Harada, Akihiro, Zhang, Hong, Koruyucu, Mine, Seymen, Figen, Hu, Jan C.-C., Simmer, James P., Ahmed, Mushtaq, Jafri, Hussain, Johnson, Colin A., Inglehearn, Chris F., Mighell, Alan J.

“…Amelogenesis is the process of dental enamel formation, leading to the deposition of the hardest tissue in the human body. This process requires the intricate…”
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Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction by Fukuda, Hayato, Ito, Saki, Watari, Kenji, Mogi, Chihiro, Arisawa, Mitsuhiro, Okajima, Fumikazu, Kurose, Hitoshi, Shuto, Satoshi

“…GPR4, a pH-sensing G protein-coupled receptor, is highly expressed in endothelial cells and may be activated in myocardial infarction due the decreased tissue…”
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Role of Scavenger Receptor Class B Type I and Sphingosine 1-Phosphate Receptors in High Density Lipoprotein-induced Inhibition of Adhesion Molecule Expression in Endothelial Cells by Kimura, Takao, Tomura, Hideaki, Mogi, Chihiro, Kuwabara, Atsushi, Damirin, Alatangaole, Ishizuka, Tamotsu, Sekiguchi, Akihiro, Ishiwara, Mitsuteru, Im, Doon-Soon, Sato, Koichi, Murakami, Masami, Okajima, Fumikazu

“…We characterized the molecular mechanisms by which high density lipoprotein (HDL) inhibits the expression of adhesion molecules, including vascular cell…”
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Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo by Komachi, Mayumi, Sato, Koichi, Tobo, Masayuki, Mogi, Chihiro, Yamada, Takayuki, Ohta, Hideo, Tomura, Hideaki, Kimura, Takao, Im, Dong‐Soon, Yanagida, Keisuke, Ishii, Satoshi, Takeyoshi, Izumi, Okajima, Fumikazu

“…Pancreatic cancer is highly metastatic and has a poor prognosis. However, there is no established treatment for pancreatic cancer. Lysophosphatidic acid (LPA)…”
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Proton-sensing ovarian cancer G protein-coupled receptor 1 on dendritic cells is required for airway responses in a murine asthma model by Aoki, Haruka, Mogi, Chihiro, Hisada, Takeshi, Nakakura, Takashi, Kamide, Yosuke, Ichimonji, Isao, Tomura, Hideaki, Tobo, Masayuki, Sato, Koichi, Tsurumaki, Hiroaki, Dobashi, Kunio, Mori, Tetsuya, Harada, Akihiro, Yamada, Masanobu, Mori, Masatomo, Ishizuka, Tamotsu, Okajima, Fumikazu

“…Ovarian cancer G protein-coupled receptor 1 (OGR1) stimulation by extracellular protons causes the activation of G proteins and subsequent cellular functions…”
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Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses by Tobo, Ayaka, Tobo, Masayuki, Nakakura, Takashi, Ebara, Masashi, Tomura, Hideaki, Mogi, Chihiro, Im, Dong-Soon, Murata, Naoya, Kuwabara, Atsushi, Ito, Saki, Fukuda, Hayato, Arisawa, Mitsuhiro, Shuto, Satoshi, Nakaya, Michio, Kurose, Hitoshi, Sato, Koichi, Okajima, Fumikazu

“…G protein-coupled receptor 4 (GPR4), previously proposed as the receptor for sphingosylphosphorylcholine, has recently been identified as the proton-sensing G…”
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Mechanism and Role of High Density Lipoprotein-induced Activation of AMP-activated Protein Kinase in Endothelial Cells by Kimura, Takao, Tomura, Hideaki, Sato, Koichi, Ito, Masaaki, Matsuoka, Isao, Im, Doon-Soon, Kuwabara, Atsushi, Mogi, Chihiro, Itoh, Hiroshi, Kurose, Hitoshi, Murakami, Masami, Okajima, Fumikazu

“…The upstream signaling pathway leading to the activation of AMP-activated protein kinase (AMPK) by high density lipoprotein (HDL) and the role of AMPK in…”
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Protective Role of Proton-Sensing TDAG8 in Lipopolysaccharide-Induced Acute Lung Injury by Tsurumaki, Hiroaki, Mogi, Chihiro, Aoki-Saito, Haruka, Tobo, Masayuki, Kamide, Yosuke, Yatomi, Masakiyo, Sato, Koichi, Dobashi, Kunio, Ishizuka, Tamotsu, Hisada, Takeshi, Yamada, Masanobu, Okajima, Fumikazu

“…Acute lung injury is characterized by the infiltration of neutrophils into lungs and the subsequent impairment of lung function. Here we explored the role of…”
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Deficiency of Proton-Sensing Ovarian Cancer G Protein-Coupled Receptor 1 Attenuates Glucose-Stimulated Insulin Secretion by Nakakura, Takashi, Mogi, Chihiro, Tobo, Masayuki, Tomura, Hideaki, Sato, Koichi, Kobayashi, Masaki, Ohnishi, Hiroshi, Tanaka, Shigeyasu, Wayama, Mitsutoshi, Sugiyama, Tetsuya, Kitamura, Tadahiro, Harada, Akihiro, Okajima, Fumikazu

“…Ovarian cancer G protein-coupled receptor 1 (OGR1) has been shown as a receptor for protons. In the present study, we aimed to know whether OGR1 plays a role…”
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