Search Results - "Moghimi, S.M."

Factors Controlling Nanoparticle Pharmacokinetics: An Integrated Analysis and Perspective by MOGHIMI, S. M, HUNTER, A. C, ANDRESEN, T. L

“…Intravenously injected nanoparticulate drug carriers provide a wide range of unique opportunities for site-specific targeting of therapeutic agents to many…”
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A brief history of long circulating nanoparticles by Haroon, H.B., Hunter, A.C., Farhangrazi, Z.S., Moghimi, S.M.

“…[Display omitted] •Kupffer cells rapidly intercept colloidal particles from the blood.•Predosing with placebo particles prolongs the circulation time of test…”
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Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties by Moghimi, S.M., Szebeni, J.

“…This article critically examines and evaluates the likely mechanisms that contribute to prolonged circulation times of sterically protected nanoparticles and…”
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Investigation of nanofluid flow in the channel under effect of magnetic field and joule heating by Moghimi, S.M., Hosseinzadeh, Khashayar, Hasibi, A.

“…In this study of the nanofluid flow in a channel, the power of the magnetic field has been introduced to the momentum and energy equations as an innovative…”
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Peptide and nucleic acid-directed self-assembly of cationic nanovehicles through giant unilamellar vesicle modification: Targetable nanocomplexes for in vivo nucleic acid delivery by Tagalakis, A.D., Maeshima, R., Yu-Wai-Man, C., Meng, J., Syed, F., Wu, L.-P., Aldossary, A.M., McCarthy, D., Moghimi, S.M., Hart, S.L.

“…[Display omitted] One of the greatest challenges for the development of genetic therapies is the efficient targeted delivery of therapeutic nucleic acids…”
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The effect of methoxy-PEG chain length and molecular architecture on lymph node targeting of immuno-PEG liposomes by Moghimi, S.M.

“…The rate of drainage and lymphatic distribution of subcutaneously injected liposomes is controlled by inclusion of methoxypoly(ethyleneglycol),…”
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Serum-mediated recognition of liposomes by phagocytic cells of the reticuloendothelial system – The concept of tissue specificity by Moghimi, S.M, Patel, H.M

“…The mechanisms responsible for the clearance and recognition of intravenously injected liposomes by phagocytic cells of the reticuloendothelial system are…”
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Mechanisms of splenic clearance of blood cells and particles: towards development of new splenotropic agents by Moghimi, S.M.

“…The mammalian spleen is quintessentially a filter of the blood and a pre-eminent reticuloendothelial organ, possessing a large capacity for removing blood…”
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Numerical and analytical approaches to MHD Jeffery-Hamel flow in a porous channel by Bararnia, H, Ganji, Z.Z, Ganji, D.D, Moghimi, S.M

“…Purpose - The main purpose of the work is to demonstrate the eligibility of the methods applied and to have the more reliable and user friendly approaches to…”
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Characterization of cisplatin-loaded cubosomes and hexosomes : Effect of mixing with human plasma by Mat Azmi, I.D, Nilsson, C, Stürup, S, Østergaard, J, Gammelgaard, B, Moghimi, S.M, Urtti, A

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Cancer nanomedicine and the complement system activation paradigm: anaphylaxis and tumour growth by Moghimi, S M

“…A wide variety of nanocarriers and particularly cancer nanomedicines activate the complement system, which is the first line of the innate immune defence…”
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Exploiting bone marrow microvascular structure for drug delivery and future therapies by Moghimi, S.M.

“…The endothelium of bone marrow sinusoids regulates many important physiological functions. On the one hand, it serves as a gatekeeper controlling cellular…”
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Complement activation turnover on surfaces of nanoparticles by Moghimi, S.M., Simberg, D.

“…[Display omitted] •Adsorbed proteins play a role in complement activation at nanoparticle surface.•The complement protein C3b can attack adsorbed…”
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CAR T-cell bioengineering: Single variable domain of heavy chain antibody targeted CARs by Rahbarizadeh, F., Ahmadvand, D., Moghimi, S.M.

“…Redirecting the recognition specificity of T lymphocytes to designated tumour cell surface antigens by transferring chimeric antigen receptor (CAR) genes is…”
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Non-phagocytic uptake of intravenously injected microspheres in rat spleen: influence of particle size and hydrophilic coating by Moghimi, S M, Porter, C J, Muir, I S, Illum, L, Davis, S S

“…A recent development in prolonging the circulation time of drug carriers, such as liposomes and microspheres, has been to minimize their removal by macrophages…”
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Role of natural antibodies and protein corona in complement C3 deposition on preclinical and clinical nanomedicines by Vu, Vivian, Chen, Fangfang, Saba, Laura, Moghimi, S.M, Simberg, Dmitri

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Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process by Hamad, I., Hunter, A.C., Szebeni, J., Moghimi, S.M.

“…Poly(ethylene glycol) (PEG) is receiving increasing attention as an intravenous therapeutic agent per se in a variety of experimental therapeutics and…”
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Hyaluronan-coated nanoparticles: The influence of the molecular weight on CD44-hyaluronan interactions and on the immune response by Mizrahy, Shoshy, Raz, Sabina Rebe, Hasgaard, Martin, Liu, Hong, Soffer-Tsur, Neta, Cohen, Keren, Dvash, Ram, Landsman-Milo, Dalit, Bremer, Maria G.E.G., Moghimi, S. Moein, Peer, Dan

“…Hyaluronan (HA), a naturally occurring glycosaminoglycan, exerts different biological functions depending on its molecular weight ranging from 4000–10M Da…”
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Molecular mechanisms of complement attack on block copolymer-coated long circulating nanoparticles by Moghimi, S.M., Hunter, A.C.

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Complement activation cascade triggered by PEG–PL engineered nanomedicines and carbon nanotubes: The challenges ahead by Moghimi, S.M., Andersen, A.J., Hashemi, S.H., Lettiero, B., Ahmadvand, D., Hunter, A.C., Andresen, T.L., Hamad, I., Szebeni, J.

“…Since their introduction, poly(ethylene glycol)–phospholipid (PEG–PL) conjugates have found many applications in design and engineering of nanosized delivery…”
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