Search Results - "Mofrad, Mohammad R.K."

On the Activation of Integrin αIIbβ3: Outside-in and Inside-out Pathways by Mehrbod, Mehrdad, Trisno, Stephen, Mofrad, Mohammad R.K.

“…Integrin αIIbβ3 is a member of the integrin family of transmembrane proteins present on the plasma membrane of platelets. Integrin αIIbβ3 is widely known to…”
Get full text

A Disulfide Bond Is Required for the Transmission of Forces through SUN-KASH Complexes by Jahed, Zeinab, Shams, Hengameh, Mofrad, Mohammad R.K.

“…Numerous biological functions of a cell, including polarization, differentiation, division, and migration, rely on its ability to endure mechanical forces…”
Get full text

A Molecular Trajectory of α-Actinin Activation by Shams, Hengameh, Golji, Javad, Mofrad, Mohammad R.K.

“…The mechanisms by which living cells respond to mechanical stimuli are not yet fully understood. It has been suggested that mechanosensing proteins play an…”
Get full text

Force-induced activation of Talin and its possible role in focal adhesion mechanotransduction by Lee, Seung E, Kamm, Roger D, Mofrad, Mohammad R.K

“…Abstract It is now well established that cells can sense mechanical force, but the mechanisms by which force is transduced into a biochemical signal remain…”
Get full text

Vinculin Activation Is Necessary for Complete Talin Binding by Golji, Javad, Lam, Johnny, Mofrad, Mohammad R.K.

“…Focal adhesions are critical to a number of cellular processes that involve mechanotransduction and mechanical interaction with the cellular environment. The…”
Get full text

Biomechanical properties of native and tissue engineered heart valve constructs by Hasan, Anwarul, Ragaert, Kim, Swieszkowski, Wojciech, Selimović, Šeila, Paul, Arghya, Camci-Unal, Gulden, Mofrad, Mohammad R.K, Khademhosseini, Ali

“…Abstract Due to the increasing number of heart valve diseases, there is an urgent clinical need for off-the-shelf tissue engineered heart valves. While…”
Get full text

Kindlin Assists Talin to Promote Integrin Activation by Haydari, Zainab, Shams, Hengameh, Jahed, Zeinab, Mofrad, Mohammad R.K.

“…Integrin αIIbβ3 is a predominant type of integrin abundantly expressed on the surface of platelets and its activation regulates the process of thrombosis…”
Get full text

Probabilistic variable-length segmentation of protein sequences for discriminative motif discovery (DiMotif) and sequence embedding (ProtVecX) by Asgari, Ehsaneddin, McHardy, Alice C., Mofrad, Mohammad R. K.

“…In this paper, we present peptide-pair encoding (PPE), a general-purpose probabilistic segmentation of protein sequences into commonly occurring…”
Get full text

Mechanotransduction Pathways Linking the Extracellular Matrix to the Nucleus by Jahed, Zeinab, Shams, Hengameh, Mehrbod, Mehrdad, Mofrad, Mohammad R.K.

“…Cells contain several mechanosensing components that transduce mechanical signals into biochemical cascades. During cell–ECM adhesion, a complex network of…”
Get full text

Gelatin/chondroitin sulfate nanofibrous scaffolds for stimulation of wound healing: In‐vitro and in‐vivo study by Pezeshki‐Modaress, Mohamad, Mirzadeh, Hamid, Zandi, Mojgan, Rajabi‐Zeleti, Sareh, Sodeifi, Niloofar, Aghdami, Nasser, Mofrad, Mohammad R. K.

“…In this research, fabrication of gelatin/chondroitin sulfate (GAG) nanofibrous scaffolds using electrospinning technique for skin tissue engineering was…”
Get full text

Micro and nanotechnologies in heart valve tissue engineering by Hasan, Anwarul, Saliba, John, Pezeshgi Modarres, Hassan, Bakhaty, Ahmed, Nasajpour, Amir, Mofrad, Mohammad R.K, Sanati-Nezhad, Amir

“…Abstract Due to the increased morbidity and mortality resulting from heart valve diseases, there is a growing demand for off-the-shelf implantable tissue…”
Get full text

Computational Modeling of Axonal Microtubule Bundles under Tension by Peter, Stephen J., Mofrad, Mohammad R.K.

“…Microtubule bundles cross-linked by tau protein serve a variety of neurological functions including maintaining mechanical integrity of the axon, promoting…”
Get full text

Dynamic Regulation of α-Actinin’s Calponin Homology Domains on F-Actin by Shams, Hengameh, Golji, Javad, Garakani, Kiavash, Mofrad, Mohammad R.K.

“…α-Actinin is an essential actin cross-linker involved in cytoskeletal organization and dynamics. The molecular conformation of α-actinin’s actin-binding domain…”
Get full text

Buckling Behavior of Individual and Bundled Microtubules by Soheilypour, Mohammad, Peyro, Mohaddeseh, Peter, Stephen J., Mofrad, Mohammad R.K.

“…As the major structural constituent of the cytoskeleton, microtubules (MTs) serve a variety of biological functions that range from facilitating organelle…”
Get full text

Rheology of the Cytoskeleton by MOFRAD, Mohammad R. K

“…The cytoskeleton is the primary internal structure of the cell, providing its structural integrity. The rheology and mechanics of the cytoskeleton, therefore,…”
Get full text

Intranuclear strain in living cells subjected to substrate stretching: A combined experimental and computational study by Tsukamoto, Shingo, Asakawa, Takumi, Kimura, Shun, Takesue, Naoyuki, Mofrad, Mohammad R.K., Sakamoto, Naoya

“…Nuclear deformation caused by mechanical stimuli has been suggested to significantly impact various cellular activities, such as gene expression, protein…”
Get full text

Torsional Behavior of Axonal Microtubule Bundles by Lazarus, Carole, Soheilypour, Mohammad, Mofrad, Mohammad R.K.

“…Axonal microtubule (MT) bundles crosslinked by microtubule-associated protein (MAP) tau are responsible for vital biological functions such as maintaining…”
Get full text

Consistent trilayer biomechanical modeling of aortic valve leaflet tissue by Bakhaty, Ahmed A., Govindjee, Sanjay, Mofrad, Mohammad R.K.

“…Aortic valve tissue exhibits highly nonlinear, anisotropic, and heterogeneous material behavior due to its complex microstructure. A thorough understanding of…”
Get full text

A molecular model for LINC complex regulation: activation of SUN2 for KASH binding by Jahed, Zeinab, Vu, Uyen T, Fadavi, Darya, Ke, Huimin, Rathish, Akshay, Kim, Samuel C J, Feng, Wei, Mofrad, Mohammad R K

“…Linkers of the nucleoskeleton and cytoskeleton are key molecular complexes that span the nuclear envelope (NE) and provide a direct linkage between the…”
Get full text

The interaction of vinculin with actin by Golji, Javad, Mofrad, Mohammad R K

“…Vinculin can interact with F-actin both in recruitment of actin filaments to the growing focal adhesions and also in capping of actin filaments to regulate…”
Get full text