Search Results - "Moffett, John R"

Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics and Oncogenesis-Part 1: Acetyl-CoA, Acetogenesis and Acyl-CoA Short-Chain Synthetases by Moffett, John R, Puthillathu, Narayanan, Vengilote, Ranjini, Jaworski, Diane M, Namboodiri, Aryan M

“…Acetate is a major end product of bacterial fermentation of fiber in the gut. Acetate, whether derived from the diet or from fermentation in the colon, has…”
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The end of the road for the tryptophan depletion concept in pregnancy and infection by Badawy, Abdulla A-B, Namboodiri, Aryan M A, Moffett, John R

“…We hypothesize that: (1) L-tryptophan (Trp) is greatly utilized and not depleted in pregnancy; (2) fetal tolerance is achieved in part through…”
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Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics, and Oncogenesis - Part 2: Acetate and ACSS2 in Health and Disease by Moffett, John R, Puthillathu, Narayanan, Vengilote, Ranjini, Jaworski, Diane M, Namboodiri, Aryan M

“…Acetate, the shortest chain fatty acid, has been implicated in providing health benefits whether it is derived from the diet or is generated from microbial…”
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Quinolinate as a Marker for Kynurenine Metabolite Formation and the Unresolved Question of NAD + Synthesis During Inflammation and Infection by Moffett, John R, Arun, Peethambaran, Puthillathu, Narayanan, Vengilote, Ranjini, Ives, John A, Badawy, Abdulla A-B, Namboodiri, Aryan M

“…Quinolinate (Quin) is a classic example of a biochemical double-edged sword, acting as both essential metabolite and potent neurotoxin. Quin is an important…”
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Tryptophan and the immune response by Moffett, John R, Namboodiri, MA Aryan

“…The immune system continuously modulates the balance between responsiveness to pathogens and tolerance to non‐harmful antigens. The mechanisms that mediate…”
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Isoflurane-lipid emulsion injection as an anticonvulsant and neuroprotectant treatment for nerve agent exposure by Krishnan, Jishnu K S, Moffett, John R, Puthillathu, Narayanan, Johnson, Erik A, Namboodiri, Aryan M

“…We have shown that briefly inhaled isoflurane rapidly halts convulsions and protects the central nervous system (CNS) from organophosphate-induced neuronal…”
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Brief isoflurane administration as an adjunct treatment to control organophosphate-induced convulsions and neuropathology by Puthillathu, Narayanan, Moffett, John R, Korotcov, Alexandru, Bosomtwi, Asamoah, Vengilote, Ranjini, Krishnan, Jishnu K S, Johnson, Erik A, Arun, Peethambaran, Namboodiri, Aryan M

“…Organophosphate-based chemical agents (OP), including nerve agents and certain pesticides such as paraoxon, are potent acetylcholinesterase inhibitors that…”
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Effects of N-Acetylaspartylglutamate (NAAG) Peptidase Inhibition on Release of Glutamate and Dopamine in Prefrontal Cortex and Nucleus Accumbens in Phencyclidine Model of Schizophrenia by Zuo, Daiying, Bzdega, Tomasz, Olszewski, Rafal T., Moffett, John R., Neale, Joseph H.

“…The “glutamate” theory of schizophrenia emerged from the observation that phencyclidine (PCP), an open channel antagonist of the NMDA subtype of glutamate…”
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N-Acetylaspartate reductions in brain injury: impact on post-injury neuroenergetics, lipid synthesis, and protein acetylation by Moffett, John R, Arun, Peethambaran, Ariyannur, Prasanth S, Namboodiri, Aryan M A

“…N-Acetylaspartate (NAA) is employed as a non-invasive marker for neuronal health using proton magnetic resonance spectroscopy (MRS). This utility is afforded…”
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Acss2 Deletion Reveals Functional Versatility via Tissue-Specific Roles in Transcriptional Regulation by Vasudevan, Narayanan Puthillathu, Soni, Dharmendra K, Moffett, John R, Krishnan, Jishnu K S, Appu, Abhilash P, Ghoshal, Sarani, Arun, Peethambaran, Denu, John M, Flagg, Thomas P, Biswas, Roopa, Namboodiri, Aryan M

“…The coordination of cellular biological processes is regulated in part via metabolic enzymes acting to match cellular metabolism to current conditions. The…”
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Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: Implications for specialized acetyl coenzyme A metabolism in the CNS by Ariyannur, Prasanth S, Moffett, John R, Manickam, Pachiappan, Pattabiraman, Nagarajan, Arun, Peethambaran, Nitta, Atsumi, Nabeshima, Toshitaka, Madhavarao, Chikkathur N, Namboodiri, Aryan M.A

“…Abstract N -acetylaspartate (NAA) is a concentrated, neuron-specific brain metabolite routinely used as a magnetic resonance spectroscopy marker for brain…”
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A role for the locus coeruleus in the analgesic efficacy of N-acetylaspartylglutamate peptidase (GCPII) inhibitors ZJ43 and 2-PMPA by Nonaka, Takahiro, Yamada, Toshihiko, Ishimura, Tatsuhiro, Zuo, Daiying, Moffett, John R, Neale, Joseph H, Yamamoto, Tatsuo

“…N-acetylaspartylglutamate (NAAG) is the third most prevalent and widely distributed neurotransmitter in the mammalian nervous system. NAAG activates a group II…”
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Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain by Ariyannur, Prasanth S., Moffett, John R., Madhavarao, Chikkathur N., Arun, Peethambaran, Vishnu, Nisha, Jacobowitz, David M., Hallows, William C., Denu, John M., Namboodiri, Aryan M.A.

“…Acetyl coenzyme A synthetase‐1 (AceCS1) catalyzes the synthesis of acetyl coenzyme A from acetate and coenzyme A and is thought to play diverse roles ranging…”
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Increasing N-acetylaspartate in the Brain during Postnatal Myelination Does Not Cause the CNS Pathologies of Canavan Disease by Appu, Abhilash P, Moffett, John R, Arun, Peethambaran, Moran, Sean, Nambiar, Vikram, Krishnan, Jishnu K S, Puthillathu, Narayanan, Namboodiri, Aryan M A

“…Canavan disease is caused by mutations in the gene encoding aspartoacylase (ASPA), a deacetylase that catabolizes N-acetylaspartate (NAA). The precise…”
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Defective N-Acetylaspartate Catabolism Reduces Brain Acetate Levels and Myelin Lipid Synthesis in Canavan's Disease by Madhavarao, Chikkathur N., Arun, Peethambaran, Moffett, John R., Szucs, Sylvia, Surendran, Sankar, Matalon, Reuben, Garbern, James, Hristova, Diana, Johnson, Anne, Jiang, Wei, M. A. Aryan Namboodiri, Snyder, Solomon H.

“…Canavan's disease (CD) is a fatal, hereditary disorder of CNS development that has been linked to mutations in the gene for the enzyme aspartoacylase (ASPA)…”
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Metabolic acetate therapy for the treatment of traumatic brain injury by Arun, Peethambaran, Ariyannur, Prasanth S, Moffett, John R, Xing, Guoqiang, Hamilton, Kristen, Grunberg, Neil E, Ives, John A, Namboodiri, Aryan M A

“…Patients suffering from traumatic brain injury (TBI) have decreased markers of energy metabolism, including N-acetylaspartate (NAA) and ATP. In the nervous…”
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NAAG Peptidase Inhibition in the Periaqueductal Gray and Rostral Ventromedial Medulla Reduces Flinching in the Formalin Model of Inflammation by Yamada, Toshihiko, Zuo, Daiying, Yamamoto, Tatsuo, Olszewski, Rafal T, Bzdega, Tomasz, Moffett, John R, Neale, Joseph H

“…Background: Metabotropic glutamate receptors (mGluRs) have been identified as significant analgesic targets. Systemic treatments with inhibitors of the enzymes…”
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Acetate supplementation induces growth arrest of NG2/PDGFRα-positive oligodendroglioma-derived tumor-initiating cells by Long, Patrick M, Tighe, Scott W, Driscoll, Heather E, Moffett, John R, Namboodiri, Aryan M A, Viapiano, Mariano S, Lawler, Sean E, Jaworski, Diane M

“…Cancer is associated with globally hypoacetylated chromatin and considerable attention has recently been focused on epigenetic therapies. N-acetyl-L-aspartate…”
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Do reductions in brain N-acetylaspartate levels contribute to the etiology of some neuropsychiatric disorders? by Ariyannur, Prasanth S., Arun, Peethambaran, Barry, Erin S., Andrews-Shigaki, Brian, Bosomtwi, Asamoah, Tang, Haiying, Selwyn, Reed, Grunberg, Neil E., Moffett, John R., Namboodiri, Aryan M.A.

“…N‐acetylaspartate (NAA) is recognized as a noninvasive diagnostic neuronal marker for a host of neuropsychiatric disorders using magnetic resonance…”
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Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease by Arun, Peethambaran, Madhavarao, Chikkathur N, Moffett, John R, Hamilton, Kristen, Grunberg, Neil E, Ariyannur, Prasanth S, Gahl, William A, Anikster, Yair, Mog, Steven, Hallows, William C, Denu, John M, Namboodiri, Aryan M. A

“…Genetic mutations that severely diminish the activity of aspartoacylase (ASPA) result in the fatal brain dysmyelinating disorder, Canavan disease. There is no…”
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