Search Results - "Moffatt, T."

Compression therapy affects collagen type balance in hypertrophic scar by Tejiram, Shawn, MD, Zhang, Jenny, BS, Travis, Taryn E., MD, Carney, Bonnie C., BS, Alkhalil, Abdulnaser, PhD, Moffatt, Lauren T., PhD, Johnson, Laura S., MD, Shupp, Jeffrey W., MD

“…Abstract Background The effects of pressure on hypertrophic scar are poorly understood. Decreased extracellular matrix deposition is hypothesized to contribute…”
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Circulating Syndecan-1 and Tissue Factor Pathway Inhibitor, Biomarkers of Endothelial Dysfunction, Predict Mortality in Burn Patients by Keyloun, John W., Le, Tuan D., Pusateri, Anthony E., Ball, Robert L., Carney, Bonnie C., Orfeo, Thomas, Brummel-Ziedins, Kathleen E., Bravo, Maria C., McLawhorn, Melissa M., Moffatt, Lauren T., Shupp, Jeffrey W.

“…The aim of this study is to evaluate the association between burn injury and admission plasma levels of Syndecan-1 (SDC-1) and Tissue Factor Pathway Inhibitor…”
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Angiogenic gene characterization and vessel permeability of dermal microvascular endothelial cells isolated from burn hypertrophic scar by Molina, Esteban A., Hartmann, Brandon, Oliver, Mary A., Kirkpatrick, Liam D., Keyloun, John W., Moffatt, Lauren T., Shupp, Jeffrey W., Travis, Taryn E., Carney, Bonnie C.

“…Hypertrophic scar (HTS) formation is a common challenge for patients after burn injury. Dermal microvascular endothelial cells (DMVECs) are an understudied…”
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Hypopigmented burn hypertrophic scar contains melanocytes that can be signaled to re-pigment by synthetic alpha-melanocyte stimulating hormone in vitro by Carney, Bonnie C, Travis, Taryn E, Moffatt, Lauren T, Johnson, Laura S, McLawhorn, Melissa M, Simbulan-Rosenthal, Cynthia M, Rosenthal, Dean S, Shupp, Jeffrey W

“…There are limited treatments for dyschromia in burn hypertrophic scars (HTSs). Initial work in Duroc pig models showed that regions of scar that are light or…”
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Review of the Terminology Describing Ionizing Radiation-Induced Skin Injury: A Case for Standardization by Burnett, Luke R., Hughes, Ryan T., Rejeski, Alexis F., Moffatt, Lauren T., Shupp, Jeffrey W., Christy, Robert J., Winkfield, Karen M.

“…Ionizing radiation causes injury to the skin that produces a complex clinical presentation that is managed by various paradigms without clear standards. The…”
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Transcriptomes of Wet Skin Biopsies Predict Outcomes after Ionizing Radiation Exposure with Potential Dosimetric Applications in a Mouse Model by Alkhalil, Abdulnaser, Clifford, John, Miller, Stacyann M, Gautam, Aarti, Jett, Marti, Hammamieh, Rasha, Moffatt, Lauren T, Shupp, Jeffrey W

“…Countermeasures for radiation diagnosis, prognosis, and treatment are trailing behind the proliferation of nuclear energy and weaponry. Radiation injury…”
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Dyspigmented hypertrophic scars: Beyond skin color by Alkhalil, Abdulnaser, Carney, Bonnie C., Travis, Taryn E., Muhie, Seid, Miller, Stacy Ann, Ramella‐Roman, Jessica C., Ghassemi, Pehman, Hammamieh, Rasha, Jett, Marti, Moffatt, Lauren T., Shupp, Jeffrey W.

“…Although pigment synthesis is well understood, relevant mechanisms of psychologically debilitating dyspigmentation in nascent tissue after cutaneous injuries…”
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Analysis of factor XIa, factor IXa and tissue factor activity in burn patients by Shupp, Jeffrey W., Prior, Shannon M., Jo, Daniel Y., Moffatt, Lauren T., Mann, Kenneth G., Butenas, Saulius

“…•TF, FXIa and FXIa are responsible for the procoagulant activity in burn patients.•Burn induced coagulopathy is driven mostly by the contact pathway.•A…”
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Inorganic polyphosphate in platelet rich plasma accelerates re-epithelialization in vitro and in vivo by Carney, Bonnie C., Simbulan-Rosenthal, Cynthia M., Gaur, Anirudh, Browne, Benjamin J., Moghe, Manish, Crooke, Elliott, Moffatt, Lauren T., Shupp, Jeffrey W., Rosenthal, Dean S.

“…Wound healing requires well-coordinated events including hemostasis, inflammation, proliferation, and remodeling. Delays in any of these stages leads to…”
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In-depth analysis of clotting dynamics in burn patients by Tejiram, Shawn, MD, Brummel-Ziedins, Kathleen E., PhD, Orfeo, Thomas, PhD, Mann, Kenneth G., PhD, Mete, Mihriye, PhD, Desale, Sameer, BS, Hamilton, Brittany N., BS, Moffatt, Lauren T., PhD, Tracy, Russell P., PhD, Shupp, Jeffrey W., MD

“…Abstract Background Studies associating coagulopathic changes with burn injury have relied on limited tests such as partial thromboplastin time (PTT) and…”
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In‐depth examination of hyperproliferative healing in two breeds of Sus scrofa domesticus commonly used for research by Funkhouser, Colton H., Kirkpatrick, Liam D., Smith, Robert D., Moffatt, Lauren T., Shupp, Jeffrey W., Carney, Bonnie C.

“…Background Wound healing can result in various outcomes, including hypertrophic scar (HTS). Pigs serve as models to study wound healing as their skin shares…”
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Comparison of Transcriptional Signatures of Three Staphylococcal Superantigenic Toxins in Human Melanocytes by Chakraborty, Nabarun, Srinivasan, Seshamalini, Yang, Ruoting, Miller, Stacy-Ann, Gautam, Aarti, Detwiler, Leanne J., Carney, Bonnie C., Alkhalil, Abdulnaser, Moffatt, Lauren T., Jett, Marti, Shupp, Jeffrey W., Hammamieh, Rasha

“…Staphylococcus aureus, a gram-positive bacterium, causes toxic shock through the production of superantigenic toxins (sAgs) known as Staphylococcal…”
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Graft loss: Review of a single burn center's experience and proposal of a graft loss grading scale by Nosanov, Lauren B., MD, McLawhorn, Melissa M., RN, BSN, Hassan, Lamisa, Travis, Taryn E., MD, Tejiram, Shawn, MD, Johnson, Laura S., MD, Moffatt, Lauren T., PhD, Shupp, Jeffrey W., MD

“…Abstract Background There exists neither consensus definition of burn “graft loss” nor a scale with which to grade severity. We introduced an institutional…”
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Reference ranges for rotational thromboelastometry in male Sprague Dawley rats by Cruz, Mariana Vigiola, Luker, Jenna N, Carney, Bonnie C, Brummel-Ziedins, Kathleen E, Bravo, Maria-Cristina, Orfeo, Thomas, Chen, Jason H, Moffatt, Lauren T, Shupp, Jeffrey W

“…A functional coagulation assay was used to investigate the extrinsic pathway of coagulation on citrated whole blood samples from healthy adult male Sprague…”
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Organ donation from burn-injured patients—a national perspective by Travis, Taryn E., MD, Johnson, Laura S., MD, Moffatt, Lauren T., PhD, Subramanian, Ram M., MD, Jordan, Marion H., MD, Shupp, Jeffrey W., MD

“…Abstract Background There is a discrepancy between publically available data from the United Network for Organ Sharing (UNOS) database and perception of the…”
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Examining the Role of Ampk for Influencing Myocardial Serca2A Expression and Function in Response to High-Fat Feeding Or Exercise Training by Susser, S.E, Morrisette, M.P, Stammers, A, Zherebitskaya, E, Moffatt, T, Premecz, S, Jassal, D.S, Duhamel, T.A

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Endothelial dysfunction is dampened by early administration of fresh frozen plasma in a rodent burn shock model by Kelly, Edward J, Ziedins, Eriks E, Carney, Bonnie C, Moffatt, Lauren T, Shupp, Jeffrey W

“…Endothelial dysfunction has been implicated in the pathogenesis of burn shock affecting patients with large thermal injury. In response to injury, glycocalyx…”
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Burn-Induced Coagulopathies: a Comprehensive Review by Ball, Robert L., Keyloun, John W., Brummel-Ziedins, Kathleen, Orfeo, Thomas, Palmieri, Tina L., Johnson, Laura S., Moffatt, Lauren T., Pusateri, Anthony E., Shupp, Jeffrey W.

“…ABSTRACTBurn-induced coagulopathy is not well understood, and consensus on diagnosis, prevention, and treatments are lacking. In this review, literature on…”
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Assessment of the Pathophysiology of Injured Tissue With an In Vivo Electrical Injury Model by Nguyen, T. T. A., Shupp, J. W., Moffatt, L. T., Jordan, M. H., Leto, E. J., Ramella-Roman, J. C.

“…Tissue destruction from electrical injury is devastating and hard to treat. Unfortunately, the pathophysiology of electrical trauma is still not well…”
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Fibrinolytic Dysfunction and Endotheliopathy After Major Thermal Injury: Considerations Needed for New Approaches to Burn Shock Resuscitation by Pusateri, Anthony E, Moffatt, Lauren T, Ho, Dao H, Neidert, Leslie E, Morgan, Clifford G, Tejiram, Shawn, Cardin, Sylvain, Shupp, Jeffrey W

“…In recent years, it has become apparent that fibrinolytic dysfunction and endotheliopathy develop in up to 40% of patients during the first hours following…”
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