Search Results - "Moffatt, Pierre"

Mutations in WNT1 are a cause of osteogenesis imperfecta by Fahiminiya, Somayyeh, Majewski, Jacek, Mort, John, Moffatt, Pierre, Glorieux, Francis H, Rauch, Frank

“…Osteogenesis imperfecta (OI) is a heritable bone fragility disorder that is usually due to dominant mutations in COL1A1 or COL1A2. Rare recessive forms of OI,…”
Get more information

The Osteogenesis Imperfecta Type V Mutant BRIL/IFITM5 Promotes Transcriptional Activation of MEF2, NFATc, and NR4A in Osteoblasts by Maranda, Vincent, Gaumond, Marie-Hélène, Moffatt, Pierre

“…BRIL (bone restricted ifitm-like; also known as IFITM5) is a transmembrane protein expressed in osteoblasts. Although its role in skeletal development and…”
Get full text

Calvaria Bone Transcriptome in Mouse Models of Osteogenesis Imperfecta by Moffatt, Pierre, Boraschi-Diaz, Iris, Marulanda, Juliana, Bardai, Ghalib, Rauch, Frank

“…Osteogenesis imperfecta (OI) is a bone fragility disorder that is usually caused by mutations affecting collagen type I. We compared the calvaria bone tissue…”
Get full text

A proline rich protein from the gingival seal around teeth exhibits antimicrobial properties against Porphyromonas gingivalis by Fouillen, Aurélien, Mary, Charline, Ponce, Katia Julissa, Moffatt, Pierre, Nanci, Antonio

“…The gingival seal around teeth prevents bacteria from destroying the tooth-supporting tissues and disseminating throughout the body. Porphyromonas gingivalis ,…”
Get full text

Expression of odontogenic ameloblast-associated and amelotin proteins in the junctional epithelium by Nishio, Clarice, Wazen, Rima, Moffatt, Pierre, Nanci, Antonio

“…Two novel proteins – odontogenic ameloblast‐associated protein and amelotin – have recently been identified in maturation‐stage ameloblasts and in the…”
Get full text

Effect of human secretory calcium-binding phosphoprotein proline-glutamine rich 1 protein on Porphyromonas gingivalis and identification of its active portions by Mary, Charline, Fouillen, Aurélien, Moffatt, Pierre, Guadarrama Bello, Dainelys, Wazen, Rima M, Grenier, Daniel, Nanci, Antonio

“…The mouth environment comprises the second most significant microbiome in the body, and its equilibrium is critical in oral health. Secretory calcium-binding…”
Get full text

The osteogenic cell surface marker BRIL/IFITM5 is dispensable for bone development and homeostasis in mice by Patoine, Alexa, Husseini, Abdallah, Kasaai, Bahar, Gaumond, Marie-Hélène, Moffatt, Pierre

“…BRIL (bone-restricted IFITM-like), is a short transmembrane protein expressed almost exclusively in osteoblasts. Although much is known about its…”
Get full text

Selective bacterial degradation of the extracellular matrix attaching the gingiva to the tooth by Fouillen, Aurélien, Grenier, Daniel, Barbeau, Jean, Baron, Christian, Moffatt, Pierre, Nanci, Antonio

“…The junctional epithelium (JE) is a specialized portion of the gingiva that seals off the tooth‐supporting tissues from the oral environment. This relationship…”
Get full text

Regulation of the Bone-restricted IFITM-like (Bril) Gene Transcription by Sp and Gli Family Members and CpG Methylation by Kasaai, Bahar, Gaumond, Marie-Hélène, Moffatt, Pierre

“…Bril encodes a small membrane protein present in osteoblasts. In humans, a single recurrent mutation in the 5′-UTR of BRIL causes osteogenesis imperfecta type…”
Get full text

Characterization of Apin, a secreted protein highly expressed in tooth-associated epithelia by Moffatt, Pierre, Smith, Charles E., St-Arnaud, René, Nanci, Antonio

“…We previously reported expression of a protein by enamel organ (EO) cells in rat incisors, originally isolated from the amyloid of Pindborg odontogenic tumors…”
Get full text

Bril: A Novel Bone‐Specific Modulator of Mineralization by Moffatt, Pierre, Gaumond, Marie‐Helene, Salois, Patrick, Sellin, Karine, Bessette, Marie‐Claude, Godin, Éric, de Oliveira, Paulo Tambasco, Atkins, Gerald J, Nanci, Antonio, Thomas, Gethin

“…In the course of attempting to define the bone “secretome” using a signal‐trap screening approach, we identified a gene encoding a small membrane protein novel…”
Get full text

Requirements for ion and solute transport, and pH regulation during enamel maturation by Lacruz, Rodrigo S., Smith, Charles E., Moffatt, Pierre, Chang, Eugene H., Bromage, Timothy G., Bringas Jr, Pablo, Nanci, Antonio, Baniwal, Sanjeev K., Zabner, Joseph, Welsh, Michael J., Kurtz, Ira, Paine, Michael L.

“…Transcellular bicarbonate transport is suspected to be an important pathway used by ameloblasts to regulate extracellular pH and support crystal growth during…”
Get full text

Cloning of rat amelotin and localization of the protein to the basal lamina of maturation stage ameloblasts and junctional epithelium by Moffatt, Pierre, Smith, Charles E, St-Arnaud, René, Simmons, Darrin, Wright, J Timothy, Nanci, Antonio

“…Formation of tooth enamel is a very complex process in which a specific set of proteins secreted by ameloblasts play a primordial role. As part of a screening…”
Get full text

Odontogenic ameloblast-associated and amelotin are novel basal lamina components by Dos Santos Neves, Juliana, Wazen, Rima M., Kuroda, Shingo, Francis Zalzal, Sylvia, Moffatt, Pierre, Nanci, Antonio

“…Odontogenic ameloblast-associated (ODAM) and amelotin (AMTN) are secreted by maturation stage ameloblasts and accumulate at the interface with enamel where an…”
Get full text

Osteocrin Is a Specific Ligand of the Natriuretic Peptide Clearance Receptor That Modulates Bone Growth by Moffatt, Pierre, Thomas, Gethin, Sellin, Karine, Bessette, Marie-Claude, Lafrenière, François, Akhouayri, Omar, St-Arnaud, René, Lanctôt, Christian

“…Osteocrin (Ostn) is a recently discovered secreted protein produced by cells of the osteoblast lineage that shows a well conserved homology with members of the…”
Get full text

Mechanical stress induces bone formation in the maxillary sinus in a short-term mouse model by Kuroda, Shingo, Wazen, Rima, Moffatt, Pierre, Tanaka, Eiji, Nanci, Antonio

“…Objectives Clinicians occasionally face the challenge of moving a tooth through the maxillary sinus. The objective of this study was to evaluate tissue…”
Get full text

Osteocrin, a Novel Bone-specific Secreted Protein That Modulates the Osteoblast Phenotype by Thomas, Gethin, Moffatt, Pierre, Salois, Patrick, Gaumond, Marie-Hélène, Gingras, Rock, Godin, Éric, Miao, Dengshun, Goltzman, David, Lanctôt, Christian

“…Although a number of secreted factors have been demonstrated to be bone regulators, none of these are unique to bone. Using a viral-based signal-trap strategy…”
Get full text

Hyaluronan production by means of Has2 gene expression in chondrocytes is essential for long bone development by Moffatt, Pierre, Lee, Eunice R., St‐Jacques, Benoit, Matsumoto, Kazu, Yamaguchi, Yu, Roughley, Peter J.

“…Mice possessing no Has2 expression in chondrocytes died near birth and displayed abnormalities throughout their skeleton. By embryonic day 18.5, the long bones…”
Get full text

Evidence by signal peptide trap technology for the expression of carbonic anhydrase 6 in rat incisor enamel organs by Smith, Charles E., Nanci, Antonio, Moffatt, Pierre

“…During screening of a rat incisor enamel organ cDNA library by signal peptide trap technology, we identified a DNA fragment matching a predicted translation…”
Get full text

Identification of secreted and membrane proteins in the rat incisor enamel organ using a signal-trap screening approach by Moffatt, Pierre, Smith, Charles E., Sooknanan, Roy, St-Arnaud, René, Nanci, Antonio

“…The secretome represents the subset of proteins that are targeted by signal peptides to the endoplasmic reticulum. Among those, secreted proteins play a…”
Get full text