Search Results - "Moffat, Kevin G"

Understanding the Pathophysiological Actions of Tau Oligomers: A Critical Review of Current Electrophysiological Approaches by Hill, Emily, Wall, Mark J., Moffat, Kevin G., Karikari, Thomas K.

“…Tau is a predominantly neuronal protein that is normally bound to microtubules, where it acts to modulate neuronal and axonal stability. In humans,…”
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Distinct Conformations, Aggregation and Cellular Internalization of Different Tau Strains by Karikari, Thomas K, Nagel, David A, Grainger, Alastair, Clarke-Bland, Charlotte, Crowe, James, Hill, Eric J, Moffat, Kevin G

“…The inter-cellular propagation of tau aggregates in several neurodegenerative diseases involves, in part, recurring cycles of extracellular tau uptake,…”
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arouser Reveals a Role for Synapse Number in the Regulation of Ethanol Sensitivity by Eddison, Mark, Guarnieri, Douglas J., Cheng, Ling, Liu, Che-Hsiung, Moffat, Kevin G., Davis, Graeme, Heberlein, Ulrike

“…A reduced sensitivity to the sedating effects of alcohol is a characteristic associated with alcohol use disorders (AUDs). A genetic screen for ethanol…”
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The C291R Tau Variant Forms Different Types of Protofibrils by Karikari, Thomas K, Thomas, Rachel, Moffat, Kevin G

“…Mutations in the gene can lead to disease-associated variants of tau. However, the pathological mechanisms behind these genetic tauopathies are poorly…”
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An AMPK-dependent regulatory pathway in tau-mediated toxicity by Galasso, Alessia, Cameron, Charles S, Frenguelli, Bruno G, Moffat, Kevin G

“…Neurodegenerative tauopathies are characterised by accumulation of hyperphosphorylated tau aggregates primarily degraded by autophagy. The 5'AMP-activated…”
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Preparation of stable tau oligomers for cellular and biochemical studies by Karikari, Thomas K., Nagel, David A., Grainger, Alastair, Clarke-Bland, Charlotte, Hill, Eric J., Moffat, Kevin G.

“…Increasing evidence suggests that small oligomers are the principal neurotoxic species of tau in Alzheimer's disease and other tauopathies. However, mechanisms…”
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Introduction of Tau Oligomers into Cortical Neurons Alters Action Potential Dynamics and Disrupts Synaptic Transmission and Plasticity by Hill, Emily, Karikari, Thomas K, Moffat, Kevin G, Richardson, Magnus J E, Wall, Mark J

“…Tau is a highly soluble microtubule-associated protein that acts within neurons to modify microtubule stability. However, abnormally phosphorylated tau…”
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Expression and purification of tau protein and its frontotemporal dementia variants using a cleavable histidine tag by Karikari, Thomas K., Turner, Alexandra, Stass, Robert, Lee, Leonie C.Y., Wilson, Bethany, Nagel, David A., Hill, Eric J., Moffat, Kevin G.

“…Recombinant tau protein is widely used to study the biochemical, cellular and pathological aspects of tauopathies, including Alzheimer's disease and…”
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Pumilio Binds para mRNA and Requires Nanos and Brat to Regulate Sodium Current in Drosophila Motoneurons by Muraro, Nara I, Weston, Andrew J, Gerber, Andre P, Luschnig, Stefan, Moffat, Kevin G, Baines, Richard A

“…Homeostatic regulation of ionic currents is of paramount importance during periods of synaptic growth or remodeling. Our previous work has identified the…”
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Differential Localization of Glutamate Receptor Subunits at the Drosophila Neuromuscular Junction by Marrus, Scott B, Portman, Scott L, Allen, Marcus J, Moffat, Kevin G, DiAntonio, Aaron

“…The subunit composition of postsynaptic neurotransmitter receptors is a key determinant of synaptic physiology. Two glutamate receptor subunits, Drosophila…”
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Extensive Plasmid Library to Prepare Tau Protein Variants and Study Their Functional Biochemistry by Karikari, Thomas K, Keeling, Sophie, Hill, Emily, Lantero Rodrı́guez, Juan, Nagel, David A, Becker, Bruno, Höglund, Kina, Zetterberg, Henrik, Blennow, Kaj, Hill, Eric J, Moffat, Kevin G

“…Tau neurofibrillary tangles are key pathological features of Alzheimer’s disease and other tauopathies. Recombinant protein technology is vital for studying…”
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Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila by Jacomin, Anne-Claire, Gohel, Raksha, Hussain, Zunoon, Varga, Agnes, Maruzs, Tamas, Eddison, Mark, Sica, Margaux, Jain, Ashish, Moffat, Kevin G, Johansen, Terje, Jenny, Andreas, Juhasz, Gabor, Nezis, Ioannis P

“…Hunger drives food-seeking behaviour and controls adaptation of organisms to nutrient availability and energy stores. Lipids constitute an essential source of…”
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Effect of brain-specific kinase-dependent tau phosphorylation on tauopathy-associated sundowning sleep behaviour by Karikari, Thomas K, Osgood, Richard, Crighton, Sophie Poppy, Moffat, Kevin G

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Regulation of Neuronal Excitability through Pumilio-Dependent Control of a Sodium Channel Gene by Mee, Christopher J, Pym, Edward C. G, Moffat, Kevin G, Baines, Richard A

“…Dynamic changes in synaptic connectivity and strength, which occur during both embryonic development and learning, have the tendency to destabilize neural…”
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RNAi screening of Drosophila (Sophophora) melanogaster S2 cells for ricin sensitivity and resistance by Pawar, Vidya, De, Antara, Briggs, Laura, Omar, Mahmoud M, Sweeney, Sean T, Lord, J Michael, Roberts, Lynne M, Spooner, Robert A, Moffat, Kevin G

“…The ribosome-inhibiting toxin ricin binds exposed β1→4 linked galactosyls on multiple glycolipids and glycoproteins on the cell surface of most eukaryotic…”
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slowmo is required for Drosophila germline proliferation by Reeve, Simon, Carhan, Ahmet, Dee, Chris T., Moffat, Kevin G.

“…Null mutations in the Drosophila gene, slowmo (slmo), result in reduced mobility and lethality in first‐instar larvae. Slowmo encodes a mitochondrial protein…”
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Targeted Expression of Truncated Glued Disrupts Giant Fiber Synapse Formation in Drosophila by Allen, Marcus J, Shan, Xiaoliang, Caruccio, Phyllis, Froggett, Stephan J, Moffat, Kevin G, Murphey, R. K

“…Glued(1) (Gl(1)) mutants produce a truncated protein that acts as a poison subunit and disables the cytoplasmic retrograde motor dynein. Heterozygous mutants…”
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A novel family of mitochondrial proteins is represented by the Drosophila genes slmo, preli-like and real-time by Dee, Chris T, Moffat, Kevin G

“…Mitochondria play essential roles in development and disease. The characterisation of mitochondrial proteins is therefore of particular importance. The slowmo…”
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isolation and characterization of temperature-dependent ricin A chain molecules in Saccharomyces cerevisiae by Allen, Stuart C.H, Moore, Katherine A.H, Marsden, Catherine J, Fülöp, Vilmos, Moffat, Kevin G, Lord, J. Michael, Ladds, Graham, Roberts, Lynne M

“…Ricin is a heterodimeric plant protein that is potently toxic to mammalian cells. Toxicity results from the catalytic depurination of eukaryotic ribosomes by…”
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Mutation in slowmo causes defects in Drosophila larval locomotor behaviour by Carhan, Ahmet, Reeve, Simon, Dee, Chris T, Baines, Richard A, Moffat, Kevin G

“…We have identified a mutant slowmotion phenotype in first instar larval peristaltic behaviour of Drosophila. By the end of embryogenesis and during early first…”
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