Search Results - "Moffat, Katy"

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses by Tan, Tiong Kit, Rijal, Pramila, Rahikainen, Rolle, Keeble, Anthony H., Schimanski, Lisa, Hussain, Saira, Harvey, Ruth, Hayes, Jack W. P., Edwards, Jane C., McLean, Rebecca K., Martini, Veronica, Pedrera, Miriam, Thakur, Nazia, Conceicao, Carina, Dietrich, Isabelle, Shelton, Holly, Ludi, Anna, Wilsden, Ginette, Browning, Clare, Zagrajek, Adrian K., Bialy, Dagmara, Bhat, Sushant, Stevenson-Leggett, Phoebe, Hollinghurst, Philippa, Tully, Matthew, Moffat, Katy, Chiu, Chris, Waters, Ryan, Gray, Ashley, Azhar, Mehreen, Mioulet, Valerie, Newman, Joseph, Asfor, Amin S., Burman, Alison, Crossley, Sylvia, Hammond, John A., Tchilian, Elma, Charleston, Bryan, Bailey, Dalan, Tuthill, Tobias J., Graham, Simon P., Duyvesteyn, Helen M. E., Malinauskas, Tomas, Huo, Jiandong, Tree, Julia A., Buttigieg, Karen R., Owens, Raymond J., Carroll, Miles W., Daniels, Rodney S., McCauley, John W., Stuart, David I., Huang, Kuan-Ying A., Howarth, Mark, Townsend, Alain R.

“…There is need for effective and affordable vaccines against SARS-CoV-2 to tackle the ongoing pandemic. In this study, we describe a protein nanoparticle…”
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The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins by Conceicao, Carina, Thakur, Nazia, Human, Stacey, Kelly, James T, Logan, Leanne, Bialy, Dagmara, Bhat, Sushant, Stevenson-Leggett, Phoebe, Zagrajek, Adrian K, Hollinghurst, Philippa, Varga, Michal, Tsirigoti, Christina, Tully, Matthew, Chiu, Chris, Moffat, Katy, Silesian, Adrian Paul, Hammond, John A, Maier, Helena J, Bickerton, Erica, Shelton, Holly, Dietrich, Isabelle, Graham, Stephen C, Bailey, Dalan

“…SARS Coronavirus 2 (SARS-CoV-2) emerged in late 2019, leading to the Coronavirus Disease 2019 (COVID-19) pandemic that continues to cause significant global…”
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A simple and rapid approach to develop recombinant avian herpesvirus vectored vaccines using CRISPR/Cas9 system by Tang, Na, Zhang, Yaoyao, Pedrera, Miriam, Chang, Pengxiang, Baigent, Susan, Moffat, Katy, Shen, Zhiqiang, Nair, Venugopal, Yao, Yongxiu

“…•Development of a rapid pipeline for generating recombinant HVT-based vaccines.•NHEJ repair pathway makes targeted insertion of the foreign gene more…”
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Demonstration of Co-Infection and Trans-Encapsidation of Viral RNA In Vitro Using Epitope-Tagged Foot-and-Mouth Disease Viruses by Childs, Kay, Juleff, Nicholas, Moffat, Katy, Seago, Julian

“…Foot-and-mouth disease, caused by foot-and-mouth disease virus (FMDV), is an economically devastating disease affecting several important livestock species…”
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Proviral ALV-LTR Sequence Is Essential for Continued Proliferation of the ALV-Transformed B Cell Line by Roy, Swagata, Bondada, Megha Sravani, Zhang, Yaoyao, Moffat, Katy, Nair, Venugopal, Yao, Yongxiu

“…Avian leukosis virus (ALV) induces B-cell lymphomas and other malignancies in chickens through insertional activation of oncogenes, and activation has been…”
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A guide to viral inclusions, membrane rearrangements, factories, and viroplasm produced during virus replication by Netherton, Christopher, Moffat, Katy, Brooks, Elizabeth, Wileman, Thomas

“…Virus replication can cause extensive rearrangement of host cell cytoskeletal and membrane compartments leading to the "cytopathic effect" that has been the…”
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Single-cell analysis reveals lasting immunological consequences of influenza infection and respiratory immunization in the pig lung by Muir, Andrew, Paudyal, Basudev, Schmidt, Selma, Sedaghat-Rostami, Ehsan, Chakravarti, Soumendu, Villanueva-Hernández, Sonia, Moffat, Katy, Polo, Noemi, Angelopoulos, Nicos, Schmidt, Anna, Tenbusch, Matthias, Freimanis, Graham, Gerner, Wilhelm, Richard, Arianne C, Tchilian, Elma

“…The pig is a natural host for influenza viruses and integrally involved in virus evolution through interspecies transmissions between humans and swine. Swine…”
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V5 and GFP Tagging of Viral Gene pp38 of Marek's Disease Vaccine Strain CVI988 Using CRISPR/Cas9 Editing by Li, Weicheng, Zhang, Yaoyao, Moffat, Katy, Nair, Venugopal, Yao, Yongxiu

“…Marek's disease virus (MDV) is a member of alphaherpesviruses associated with Marek's disease, a highly contagious neoplastic disease in chickens. The…”
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Generation of A Triple Insert Live Avian Herpesvirus Vectored Vaccine Using CRISPR/Cas9-Based Gene Editing by Tang, Na, Zhang, Yaoyao, Sadigh, Yashar, Moffat, Katy, Shen, Zhiqiang, Nair, Venugopal, Yao, Yongxiu

“…Herpesvirus of turkeys (HVT), used originally as a vaccine against Marek's disease (MD), has recently been shown to be a highly effective viral vector for…”
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Foot-and-mouth disease virus replicates independently of phosphatidylinositol 4-phosphate and type III phosphatidylinositol 4-kinases by Berryman, Stephen, Moffat, Katy, Harak, Christian, Lohmann, Volker, Jackson, Terry

“…Picornaviruses form replication complexes in association with membranes in structures called replication organelles. Common themes to emerge from studies of…”
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Deletion of the K145R and DP148R Genes from the Virulent ASFV Georgia 2007/1 Isolate Delays the Onset, but Does Not Reduce Severity, of Clinical Signs in Infected Pigs by Rathakrishnan, Anusyah, Reis, Ana L, Goatley, Lynnette C, Moffat, Katy, Dixon, Linda K

“…African swine fever virus causes a frequently fatal disease of domestic pigs and wild boar that has a high economic impact across 3 continents. The large…”
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Production of Recombinant African Swine Fever Viruses: Speeding Up the Process by Rathakrishnan, Anusyah, Moffat, Katy, Reis, Ana Luisa, Dixon, Linda K

“…African swine fever (ASF) is a devastating disease in pigs, with no vaccines for control. The genetic manipulation of African swine fever virus (ASFV) is often…”
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CRISPR-Mediated Gene Activation (CRISPRa) of pp38/pp24 Orchestrates Events Triggering Lytic Infection in Marek’s Disease Virus-Transformed Cell Lines by Roy, Poornima, Moffat, Katy, Nair, Venugopal, Yao, Yongxiu

“…Marek’s disease (MD) is an immunosuppressive and highly contagious lymphoproliferative disease caused by Marek’s disease virus (MDV) in poultry. Lymphoblastoid…”
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An Improved αvβ6-Receptor-Expressing Suspension Cell Line for Foot-and-Mouth Disease Vaccine Production by Harvey, Yongjie, Jackson, Ben, Carr, Brigid Veronica, Childs, Kay, Moffat, Katy, Freimanis, Graham, Tennakoon, Chandana, Juleff, Nicholas, Seago, Julian

“…Foot-and-mouth disease (FMD) is endemic in large parts of sub-Saharan Africa, Asia and South America, where outbreaks in cloven-hooved livestock threaten food…”
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A protective multiple gene-deleted African swine fever virus genotype II, Georgia 2007/1, expressing a modified non-haemadsorbing CD2v protein by Rathakrishnan, Anusyah, Reis, Ana L, Petrovan, Vlad, Goatley, Lynnette C, Moffat, Katy, Lui, Yuan, Vuong, Mai T, Ikemizu, Shinji, Davis, Simon J, Dixon, Linda K

“…African swine fever virus is a complex DNA virus that causes high fatality in pigs and wild boar and has a great socio-economic impact. An attenuated genotype…”
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Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans by Holzer, Barbara, Rijal, Pramila, McNee, Adam, Paudyal, Basudev, Martini, Veronica, Clark, Becky, Manjegowda, Tanuja, Salguero, Francisco J, Bessell, Emily, Schwartz, John C, Moffat, Katy, Pedrera, Miriam, Graham, Simon P, Noble, Alistair, Bonnet-Di Placido, Marie, La Ragione, Roberto M, Mwangi, William, Beverley, Peter, McCauley, John W, Daniels, Rodney S, Hammond, John A, Townsend, Alain R, Tchilian, Elma

“…Pigs are natural hosts for the same subtypes of influenza A viruses as humans and integrally involved in virus evolution with frequent interspecies…”
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The immune response to lumpy skin disease virus in cattle is influenced by inoculation route by Fay, Petra C, Wijesiriwardana, Najith, Munyanduki, Henry, Sanz-Bernardo, Beatriz, Lewis, Isabel, Haga, Ismar R, Moffat, Katy, van Vliet, Arnoud H M, Hope, Jayne, Graham, Simon P, Beard, Philippa M

“…Lumpy skin disease virus (LSDV) causes severe disease in cattle and water buffalo and is transmitted by hematophagous arthropod vectors. Detailed information…”
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A low-passage insect-cell isolate of bluetongue virus uses a macropinocytosis-like entry pathway to infect natural target cells derived from the bovine host by Stevens, Lisa M, Moffat, Katy, Cooke, Lyndsay, Nomikou, Kyriaki, Mertens, Peter P C, Jackson, Terry, Darpel, Karin E

“…Bluetongue virus (BTV) causes an economically important disease in domestic and wildlife ruminants and is transmitted by Culicoides biting midges. In…”
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Specific T-cell subsets have a role in anti-viral immunity and pathogenesis but not viral dynamics or onwards vector transmission of an important livestock arbovirus by Newbrook, Kerry, Khan, Nakibul, Fisher, Aimee, Chong, Karen, Gubbins, Simon, Davies, William C, Sanders, Christopher, Busquets, Marc Guimerà, Cooke, Lyndsay, Corla, Amanda, Ashby, Martin, Flannery, John, Batten, Carrie, Stokes, Jessica E, Sanz-Bernardo, Beatriz, Carpenter, Simon, Moffat, Katy, Darpel, Karin E

“…Bluetongue virus (BTV) is an arthropod-borne that is almost solely transmitted by biting midges and causes a globally important haemorrhagic disease,…”
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Targeted Editing of the pp38 Gene in Marek's Disease Virus-Transformed Cell Lines Using CRISPR/Cas9 System by Zhang, Yaoyao, Luo, Jun, Tang, Na, Teng, Man, Reddy, Vishwanatha R A P, Moffat, Katy, Shen, Zhiqiang, Nair, Venugopal, Yao, Yongxiu

“…Marek's disease virus (MDV), a lymphotropic α-herpesvirus associated with T-cell lymphomas in chickens, is an excellent model for herpesvirus biology and…”
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