Search Results - "Moffat, Ivy"

Neurotoxicity may be an overlooked consequence of benzo[a]pyrene exposure that is relevant to human health risk assessment by Chepelev, Nikolai L., Moffat, Ivy D., Bowers, Wayne J., Yauk, Carole L.

“…Benzo[a]pyrene (BaP) is a well-studied environmental compound that requires metabolic activation to have a carcinogenic effect. The neurotoxicity of BaP has…”
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Transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in liver: comparison of rat and mouse by Boutros, Paul C, Yan, Rui, Moffat, Ivy D, Pohjanvirta, Raimo, Okey, Allan B

“…Mouse and rat models are mainstays in pharmacology, toxicology and drug development -- but differences between strains and between species complicate data…”
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Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries by Tijet, Nathalie, Boutros, Paul C, Moffat, Ivy D, Okey, Allan B, Tuomisto, Jouko, Pohjanvirta, Raimo

“…Conventional biochemical and molecular techniques identified previously several genes whose expression is regulated by the aryl hydrocarbon receptor (AHR). We…”
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Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water by Moffat, Ivy, Chepelev, Nikolai L., Labib, Sarah, Bourdon-Lacombe, Julie, Kuo, Byron, Buick, Julie K., Lemieux, France, Williams, Andrew, Halappanavar, Sabina, Malik, Amal I, Luijten, Mirjam, Aubrecht, Jiri, Hyduke, Daniel R., Fornace, Albert J., Swartz, Carol D., Recio, Leslie, Yauk, Carole L.

“…Abstract Toxicogenomics is proposed to be a useful tool in human health risk assessment. However, a systematic comparison of traditional risk assessment…”
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Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities by Moffat, Ivy D, Boutros, Paul C, Chen, Hanbo, Okey, Allan B, Pohjanvirta, Raimo

“…The major toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) appear to result from dysregulation of mRNA levels mediated by the aryl hydrocarbon…”
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Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals by Bourdon-Lacombe, Julie A., Moffat, Ivy D., Deveau, Michelle, Husain, Mainul, Auerbach, Scott, Krewski, Daniel, Thomas, Russell S., Bushel, Pierre R., Williams, Andrew, Yauk, Carole L.

“…•Guidance to evaluate the quality and results of genomic data is provided.•Examples to integrate genomics information into risk assessments are provided.•This…”
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Integrating toxicogenomics into human health risk assessment: Lessons learned from the benzo[a]pyrene case study by Chepelev, Nikolai L., Moffat, Ivy D., Labib, Sarah, Bourdon-Lacombe, Julie, Kuo, Byron, Buick, Julie K., Lemieux, France, Malik, Amal I., Halappanavar, Sabina, Williams, Andrew, Yauk, Carole L.

“…Abstract The use of short-term toxicogenomic tests to predict cancer (or other health effects) offers considerable advantages relative to traditional toxicity…”
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microRNAs in Adult Rodent Liver Are Refractory to Dioxin Treatment by Moffat, Ivy D., Boutros, Paul C., Celius, Trine, Lindén, Jere, Pohjanvirta, Raimo, Okey, Allan B.

“…Dioxin-like chemicals are well known for their ability to upregulate expression of numerous genes via the AH receptor (AHR). However, recent transcriptomic…”
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Compendium of TCDD-mediated transcriptomic response datasets in mammalian model systems by Prokopec, Stephenie D, Houlahan, Kathleen E, Sun, Ren X, Watson, John D, Yao, Cindy Q, Lee, Jamie, P'ng, Christine, Pang, Renee, Wu, Alexander H, Chong, Lauren C, Smith, Ashley B, Harding, Nicholas J, Moffat, Ivy D, Lindén, Jere, Lensu, Sanna, Okey, Allan B, Pohjanvirta, Raimo, Boutros, Paul C

“…2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most potent congener of the dioxin class of environmental contaminants. Exposure to TCDD causes a wide range…”
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mRNA levels in control rat liver display strain-specific, hereditary, and AHR-dependent components by Boutros, Paul C, Moffat, Ivy D, Okey, Allan B, Pohjanvirta, Raimo

“…Rat is a major model organism in toxicogenomics and pharmacogenomics. Hepatic mRNA profiles after treatment with xenobiotic chemicals are used to predict and…”
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Transcriptional profiling of rat hypothalamus response to 2,3,7,8-tetrachlorodibenzo- ρ -dioxin by Houlahan, Kathleen E, Prokopec, Stephenie D, Moffat, Ivy D, Lindén, Jere, Lensu, Sanna, Okey, Allan B, Pohjanvirta, Raimo, Boutros, Paul C

“…Abstract In some mammals, halogenated aromatic hydrocarbon (HAH) exposure causes wasting syndrome, defined as significant weight loss associated with lethal…”
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Transcriptional profiling of rat white adipose tissue response to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin by Houlahan, Kathleen E., Prokopec, Stephenie D., Sun, Ren X., Moffat, Ivy D., Lindén, Jere, Lensu, Sanna, Okey, Allan B., Pohjanvirta, Raimo, Boutros, Paul C.

“…Polychlorinated dibenzodioxins are environmental contaminants commonly produced as a by-product of industrial processes. The most potent of these,…”
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Hepatic transcriptomic responses to TCDD in dioxin-sensitive and dioxin-resistant rats during the onset of toxicity by Boutros, Paul C., Yao, Cindy Q., Watson, John D., Wu, Alexander H., Moffat, Ivy D., Prokopec, Stephenie D., Smith, Ashley B., Okey, Allan B., Pohjanvirta, Raimo

“…The dioxin congener 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) causes a wide range of toxic effects in rodent species, all of which are mediated by a…”
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Cross-species transcriptomic analysis elucidates constitutive aryl hydrocarbon receptor activity by Sun, Ren X, Chong, Lauren C, Simmons, Trent T, Houlahan, Kathleen E, Prokopec, Stephenie D, Watson, John D, Moffat, Ivy D, Lensu, Sanna, Lindén, Jere, P'ng, Christine, Okey, Allan B, Pohjanvirta, Raimo, Boutros, Paul C

“…Research on the aryl hydrocarbon receptor (AHR) has largely focused on variations in toxic outcomes resulting from its activation by halogenated aromatic…”
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Toxicological implications of polymorphisms in receptors for xenobiotic chemicals: The case of the aryl hydrocarbon receptor by Okey, Allan B., Franc, Monique A., Moffat, Ivy D., Tijet, Nathalie, Boutros, Paul C., Korkalainen, Merja, Tuomisto, Jouko, Pohjanvirta, Raimo

“…Mechanistic toxicology has predominantly been focused on adverse effects that are caused by reactive metabolites or by reactive oxygen species. However, many…”
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Aryl hydrocarbon receptor splice variants in the dioxin-resistant rat: tissue expression and transactivational activity by Moffat, Ivy D, Roblin, Steven, Harper, Patricia A, Okey, Allan B, Pohjanvirta, Raimo

“…The AHR locus encodes the aryl hydrocarbon receptor (AHR), a transcriptional regulator of multiple drug-metabolizing enzymes and mediator of toxicity of…”
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Patterns of dioxin-altered mRNA expression in livers of dioxin-sensitive versus dioxin-resistant rats by Franc, Monique A., Moffat, Ivy D., Boutros, Paul C., Tuomisto, Jouni T., Tuomisto, Jouko, Pohjanvirta, Raimo, Okey, Allan B.

“…Dioxins exert their major toxicologic effects by binding to the aryl hydrocarbon receptor (AHR) and altering gene transcription. Numerous dioxin-responsive…”
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Differential expression profiling of the hepatic proteome in a rat model of dioxin resistance: correlation with genomic and transcriptomic analyses by Pastorelli, Roberta, Carpi, Donatella, Campagna, Roberta, Airoldi, Luisa, Pohjanvirta, Raimo, Viluksela, Matti, Hakansson, Helen, Boutros, Paul C, Moffat, Ivy D, Okey, Allan B, Fanelli, Roberto

“…One characteristic feature of acute 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity is dramatic interspecies and interstrain variability in sensitivity…”
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Evaluation of various housekeeping genes for their applicability for normalization of mRNA expression in dioxin-treated rats by Pohjanvirta, Raimo, Niittynen, Marjo, Lindén, Jere, Boutros, Paul C., Moffat, Ivy D., Okey, Allan B.

“…Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) is an extremely sensitive, convenient and rapid method to measure mRNA levels in cells…”
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A predictive toxicogenomics signature to classify genotoxic versus non-genotoxic chemicals in human TK6 cells by Williams, Andrew, Buick, Julie K., Moffat, Ivy, Swartz, Carol D., Recio, Leslie, Hyduke, Daniel R., Li, Heng-Hong, Fornace, Albert J., Aubrecht, Jiri, Yauk, Carole L.

“…Genotoxicity testing is a critical component of chemical assessment. The use of integrated approaches in genetic toxicology, including the incorporation of…”
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