Search Results - "Moffa, Simona"

Sotagliflozin, the first dual SGLT inhibitor: current outlook and perspectives by Cefalo, Chiara Maria Assunta, Cinti, Francesca, Moffa, Simona, Impronta, Flavia, Sorice, Gian Pio, Mezza, Teresa, Pontecorvi, Alfredo, Giaccari, Andrea

“…Sotagliflozin is a dual sodium-glucose co-transporter-2 and 1 (SGLT2/1) inhibitor for the treatment of both type 1 (T1D) and type 2 diabetes (T2D)…”
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Potential cause-effect relationship between insulin autoimmune syndrome and alpha lipoic acid: Two case reports by Moffa, Simona, Improta, Ilaria, Rocchetti, Sandro, Mezza, Teresa, Giaccari, Andrea

“…•We here report two new cases of insulin autoimmune syndrome (IAS) triggered by alpha lipoic acid in two Caucasian women.•This new cases are associated with…”
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Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features by Capece, Umberto, Moffa, Simona, Improta, Ilaria, Di Giuseppe, Gianfranco, Nista, Enrico Celestino, Cefalo, Chiara M A, Cinti, Francesca, Pontecorvi, Alfredo, Gasbarrini, Antonio, Giaccari, Andrea, Mezza, Teresa

“…Alpha-lipoic acid (ALA) is a natural compound with antioxidant and pro-oxidant properties which has effects on the regulation of insulin sensitivity and…”
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Physical Activity and Type 2 Diabetes: In Search of a Personalized Approach to Improving β-Cell Function by Di Murro, Emanuela, Di Giuseppe, Gianfranco, Soldovieri, Laura, Moffa, Simona, Improta, Ilaria, Capece, Umberto, Nista, Enrico Celestino, Cinti, Francesca, Ciccarelli, Gea, Brunetti, Michela, Gasbarrini, Antonio, Pontecorvi, Alfredo, Giaccari, Andrea, Mezza, Teresa

“…Type 2 diabetes mellitus (T2DM) is one of the most widespread diseases worldwide. Lifestyle interventions, including diet and physical activity (PA), are…”
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The Interplay between Immune System and Microbiota in Diabetes by Giaccari, Andrea, Pontecorvi, Alfredo, Santoro, Antonio, Sorice, Gian Pio, Impronta, Flavia, Cinti, Francesca, Cefalo, Chiara M. A., Mezza, Teresa, Moffa, Simona, Di Giuseppe, Gianfranco

“…Diabetes is not a single and homogeneous disease, but a cluster of metabolic diseases characterized by the common feature of hyperglycemia. The pathogenesis of…”
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A novel low-density lipoprotein receptor variant in a Ukrainian patient: a case report and overview of the disease-causing low-density lipoprotein receptor variants associated to familial hypercholesterolemia by Moffa, Simona, Onori, Maria Elisabetta, De Paolis, Elisa, Ricciardi Tenore, Claudio, Perrucci, Alessia, Pontecorvi, Alfredo, Giaccari, Andrea, Urbani, Andrea, Minucci, Angelo

“…Background Familial hypercholesterolemia (FH) is characterized by high low-density lipoprotein-cholesterol levels and it is primarily caused by…”
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Spotlight on ertugliflozin and its potential in the treatment of type 2 diabetes: evidence to date by Cinti, Francesca, Moffa, Simona, Impronta, Flavia, Cefalo, Chiara Ma, Sun, Vinsin A, Sorice, Gian Pio, Mezza, Teresa, Giaccari, Andrea

“…Sodium-glucose cotransporter 2 (SGLT2) inhibitors are the latest therapeutic strategy in the treatment of type 2 diabetes mellitus (T2DM). Using an…”
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Effects of PCSK9 inhibition on glucose metabolism and β-cell function in humans: a pilot study by Moffa, Simona, Mezza, Teresa, Ferraro, Pietro Manuel, Di Giuseppe, Gianfranco, Cefalo, Chiara M A, Cinti, Francesca, Impronta, Flavia, Capece, Umberto, Ciccarelli, Gea, Mari, Andrea, Pontecorvi, Alfredo, Giaccari, Andrea

“…Anti-PCSK9 monoclonal antibodies are effective in reducing LDL-C and cardiovascular events by neutralizing circulating PCSK9. PCSK9, however, is also expressed…”
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Bile Modulates Secretion of Incretins and Insulin: A Study of Human Extrahepatic Cholestasis by Mezza, Teresa, Moffa, Simona, Ferraro, Pietro Manuel, Quero, Giuseppe, Capece, Umberto, Carfì, Andrea, Cefalo, Chiara M A, Cinti, Francesca, Sorice, Gian Pio, Impronta, Flavia, Mari, Andrea, Pontecorvi, Alfredo, Alfieri, Sergio, Holst, Jens J, Giaccari, Andrea

“…Abstract Objective Changes in bile flow after bariatric surgery may beneficially modulate secretion of insulin and incretins, leading to diabetes remission…”
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108-OR: Insulin Resistance Is Associated with Alterations in the Dynamics of Incretin Secretion by Di Giuseppe, Gianfranco, Soldovieri, Laura, Ciccarelli, Gea, Brunetti, Michela, Cinti, Francesca, Moffa, Simona, Holst, Jens J, Giaccari, Andrea, Mezza, Teresa

“…GIP and GLP-1 exert a fundamental role in glucose homeostasis, but it is still debated if modifications in GIP and GLP-1 secretion can affect the metabolic…”
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Why do some glucose-lowering agents improve non-alcoholic fatty liver disease whereas others do not? A narrative review in search of a unifying hypothesis by Ciccarelli, Gea, Di Giuseppe, Gianfranco, Cinti, Francesca, Moffa, Simona, Mezza, Teresa, Giaccari, Andrea

“…Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) are metabolic disorders connected by common pathophysiological mechanisms. Since insulin…”
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1559-P: Heterogeneity of Trajectories of Metabolic Parameters after 50% Beta-Cell Mass Loss by Pancreatectomy by BIZZOTTO, ROBERTO, DI GIUSEPPE, GIANFRANCO, SOLDOVIERI, LAURA, CINTI, FRANCESCA, MOFFA, SIMONA, BRUNETTI, MICHELA, CICCARELLI, GEA, ALFIERI, SERGIO, QUERO, GIUSEPPE, MARI, ANDREA, GIACCARI, ANDREA, MEZZA, TERESA

“…Temporal trajectories of metabolic parameters in the onset of dysglycemia are heterogeneous. We aimed to characterize the temporal trajectories of metabolic…”
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1535-P: Type 2 Diabetes Remission after Roux-en-Y Gastric Bypass Is Related to a Reduction of Pancreatic Noradrenergic Innervation and Beta-Cell Redifferentiation by Cinti, Francesca, Avolio, Adriana, Morciano, Cassandra, Gugliandolo, Shawn, Capece, Umberto, Mezza, Teresa, Soldovieri, Laura, Ciccarelli, Gea, Di Giuseppe, Gianfranco, Moffa, Simona, Giaccari, Andrea

“…Background: β cell dedifferentiation has been identified as the process responsible for the functional "disappearance" of β cells from the islets of diabetic…”
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Pancreaticoduodenectomy model demonstrates a fundamental role of dysfunctional β cells in predicting diabetes by Mezza, Teresa, Ferraro, Pietro Manuel, Di Giuseppe, Gianfranco, Moffa, Simona, Cefalo, Chiara M.A., Cinti, Francesca, Impronta, Flavia, Capece, Umberto, Quero, Giuseppe, Pontecorvi, Alfredo, Mari, Andrea, Alfieri, Sergio, Giaccari, Andrea

“…BACKGROUND. The appearance of hyperglycemia is due to insulin resistance, functional deficits in the secretion of insulin, and a reduction of ß cell mass…”
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First-phase insulin secretion: can its evaluation direct therapeutic approaches? by Di Giuseppe, Gianfranco, Ciccarelli, Gea, Soldovieri, Laura, Capece, Umberto, Cefalo, Chiara M.A., Moffa, Simona, Nista, Enrico C., Brunetti, Michela, Cinti, Francesca, Gasbarrini, Antonio, Pontecorvi, Alfredo, Giaccari, Andrea, Mezza, Teresa

“…β Cells can adapt to pathological metabolic conditions by implementing plasticity mechanisms to increase their mass and enhance insulin secretion, thus…”
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Reduced incretin effect precedes diabetes development following duodenopancreatectomy in individuals without diabetes by Di Giuseppe, Gianfranco, Soldovieri, Laura, Ciccarelli, Gea, Ferraro, Pietro Manuel, Quero, Giuseppe, Cinti, Francesca, Capece, Umberto, Moffa, Simona, Nista, Enrico Celestino, Gasbarrini, Antonio, Mari, Andrea, Alfieri, Sergio, Tondolo, Vincenzo, Pontecorvi, Alfredo, Holst, Jens Juul, Giaccari, Andrea, Mezza, Teresa

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4772 DOUBLE FILTRATION PLASMAPHERESIS DURING HETEROLOGOUS FERTILIZATION PREGNANCY FOR THE TREATMENT OF HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA by Spasiano, Andrea, Palazzetti, Daniela, Ambrogio, Martina, Rosati, Erica, Moffa, Simona, Naticchia, Alessandro, Giaccari, Andrea, Ferraro, Pietro Manuel, Grandaliano, Giuseppe, Panocchia, Nicola

“…Abstract Background and Aims Pregnancy in women affected by familial hypercholesterolemia is rare. Estrogen and progesterone fluctuations, featuring pregnancy,…”
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1068-P: Reassessing Insulin Therapy In Diabetes of the Exocrine Pancreas-A Pilot Study by Ciccarelli, Gea, Di Giuseppe, Gianfranco, Brunetti, Michela, Soldovieri, Laura, Di Giorgi, Nicoletta, Iacomini, Chiara, Masciocchi, Carlotta, Patarnello, Stefano, Capece, Umberto, Morciano, Cassandra, Gugliandolo, Shawn, Avolio, Adriana, Moffa, Simona, Cinti, Francesca, Giaccari, Andrea, Mezza, Teresa

“…Cohort studies have demonstrated that subjects with diabetes of the exocrine pancreas (DEP) are mostly treated with basal bolus insulin. To reassess insulin…”
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1754-P: Reduced Incretin Effect Predicts Diabetes Appearance in a Cohort of Nondiabetic Subjects after Acute Beta-Cell Mass Reduction by DI GIUSEPPE, GIANFRANCO, MARIA ASSUNTA CEFALO, CHIARA, MOFFA, SIMONA, CICCARELLI, GEA, SOLDOVIERI, LAURA, CINTI, FRANCESCA, CAPECE, UMBERTO, IMPRONTA, FLAVIA, MARI, ANDREA, HOLST, JENS J., GIACCARI, ANDREA, MEZZA, TERESA

“…In type 2 diabetes incretin effect (IE) is reduced but still contributes to 20-35% of insulin response to oral glucose. One reason is the impairment of GIP and…”
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2110-P: Correlation between Ex Vivo Islet Proteomic Analysis and In Vivo Secretory Function in Humans by ASSUNTA CEFALO, CHIARA MARIA, MEZZA, TERESA, CINTI, FRANCESCA, MOFFA, SIMONA, CAPECE, UMBERTO, KULKARNI, ROHIT, GIACCARI, ANDREA

“…Insulin resistance and β-cell dysfunction are the main actors in the pathogenesis of type 2 diabetes mellitus, causing both quantitative and qualitative loss…”
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