Search Results - "Moeton, Martina"

Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease by Kamphuis, Willem, Middeldorp, Jinte, Kooijman, Lieneke, Sluijs, Jacqueline A, Kooi, Evert-Jan, Moeton, Martina, Freriks, Michel, Mizee, Mark R, Hol, Elly M

“…Abstract In Alzheimer's disease (AD), amyloid plaques are surrounded by reactive astrocytes with an increased expression of intermediate filaments including…”
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Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status by Vogel, Daphne Y S, Vereyken, Elly J F, Glim, Judith E, Heijnen, Priscilla D A M, Moeton, Martina, van der Valk, Paul, Amor, Sandra, Teunissen, Charlotte E, van Horssen, Jack, Dijkstra, Christine D

“…Macrophages play a dual role in multiple sclerosis (MS) pathology. They can exert neuroprotective and growth promoting effects but also contribute to tissue…”
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GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer disease by Kamphuis, Willem, Mamber, Carlyn, Moeton, Martina, Kooijman, Lieneke, Sluijs, Jacqueline A, Jansen, Anne H P, Verveer, Monique, de Groot, Lody R, Smith, Vanessa D, Rangarajan, Sindhoo, Rodríguez, José J, Orre, Marie, Hol, Elly M

“…Glial fibrillary acidic protein (GFAP) is the main astrocytic intermediate filament (IF). GFAP splice isoforms show differential expression patterns in the…”
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Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis by Loregger, Anke, Raaben, Matthijs, Tan, Josephine, Scheij, Saskia, Moeton, Martina, van den Berg, Marlene, Gelberg-Etel, Hila, Stickel, Elmer, Roitelman, Joseph, Brummelkamp, Thijn, Zelcer, Noam

“…OBJECTIVE—The cellular demand for cholesterol requires control of its biosynthesis by the mevalonate pathway. Regulation of HMGCR (3-hydroxy-3-methylglutaryl…”
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EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux by Nelson, Jessica Kristine, Koenis, Duco Steven, Scheij, Saskia, Cook, Emma Clare Laura, Moeton, Martina, Santos, Ana, Lobaccaro, Jean-Marc Adolphe, Baron, Silvere, Zelcer, Noam

“…OBJECTIVE—The sterol-responsive nuclear receptors, liver X receptors α (LXRα, NR1H3) and β (LXRβ, NR1H2), are key determinants of cellular cholesterol…”
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The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting by Tan, Josephine Mathilde Elisabeth, van der Stoel, Miesje Maxime, van den Berg, Marlene, van Loon, Nienke Marlies, Moeton, Martina, Scholl, Edwin, van der Wel, Nicole Neeltje, Kovačević, Igor, Hordijk, Peter Lodewijk, Loregger, Anke, Huveneers, Stephan, Zelcer, Noam

“…The endothelial monolayer forms a barrier between the lumen of blood vessels and the underlying tissues. Stable VE-cadherin-based adherens junctions are…”
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GFAP isoforms control intermediate filament network dynamics, cell morphology, and focal adhesions by Moeton, Martina, Stassen, Oscar M. J. A., Sluijs, Jacqueline A., van der Meer, Vincent W. N., Kluivers, Liselot J., van Hoorn, Hedde, Schmidt, Thomas, Reits, Eric A. J., van Strien, Miriam E., Hol, Elly M.

“…Glial fibrillary acidic protein (GFAP) is the characteristic intermediate filament (IF) protein in astrocytes. Expression of its main isoforms, GFAPα and…”
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Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene by Cook, Emma C L, Nelson, Jessica K, Sorrentino, Vincenzo, Koenis, Duco, Moeton, Martina, Scheij, Saskia, Ottenhoff, Roelof, Bleijlevens, Boris, Loregger, Anke, Zelcer, Noam

“…Cellular cholesterol metabolism is subject to tight regulation to maintain adequate levels of this central lipid molecule. Herein, the sterol-responsive Liver…”
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Silencing GFAP isoforms in astrocytoma cells disturbs laminin‐dependent motility and cell adhesion by Moeton, Martina, Kanski, Regina, Stassen, Oscar M. J. A., Sluijs, Jacqueline A., Geerts, Dirk, Tijn, Paula, Wiche, Gerhard, Strien, Miriam E., Hol, Elly M.

“…ABSTRACT Glial fibrillary acidic protein (GFAP) is an intermediate filament protein expressed in astrocytes and neural stem cells. The GFAP gene is…”
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Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes by Herrera Moro Chao, Daniela, Kallemeijn, Wouter W, Marques, Andre R A, Orre, Marie, Ottenhoff, Roelof, van Roomen, Cindy, Foppen, Ewout, Renner, Maria C, Moeton, Martina, van Eijk, Marco, Boot, Rolf G, Kamphuis, Willem, Hol, Elly M, Aten, Jan, Overkleeft, Hermen S, Kalsbeek, Andries, Aerts, Johannes M F G

“…Gaucher disease is characterized by lysosomal accumulation of glucosylceramide due to deficient activity of lysosomal glucocerebrosidase (GBA). In cells,…”
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Retraction Note: Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer by Alioui, Anthony, Dufour, Julie, Leoni, Valerio, Loregger, Anke, Moeton, Martina, Iuliano, Luigi, Zerbinati, Chiara, Septier, Amandine, Val, Pierre, Fouache, Allan, Russo, Vincenzo, Volle, David H., Lobaccaro, Jean-Marc A., Zelcer, Noam, Baron, Silvère

“…This paper has been retracted at the request of the authors…”
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RETRACTED ARTICLE: Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer by Alioui, Anthony, Dufour, Julie, Leoni, Valerio, Loregger, Anke, Moeton, Martina, Iuliano, Luigi, Zerbinati, Chiara, Septier, Amandine, Val, Pierre, Fouache, Allan, Russo, Vincenzo, Volle, David H., Lobaccaro, Jean-Marc A., Zelcer, Noam, Baron, Silvère

“…Advanced prostate cancer (PCa) is a clinical challenge as no curative therapeutic is available. In this context, a better understanding of metastasis and…”
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A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes by Loregger, Anke, Cook, Emma Claire Laura, Nelson, Jessica Kristin, Moeton, Martina, Sharpe, Laura Jane, Engberg, Susanna, Karimova, Madina, Lambert, Gilles, Brown, Andrew John, Zelcer, Noam

“…Cholesterol synthesis and lipoprotein uptake are tightly coordinated to ensure that the cellular level of cholesterol is adequately maintained. Hepatic…”
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Regulation of intestinal LDLR by the LXR-IDOL axis by van Loon, Nienke M., van Wouw, Suzanne A.E., Ottenhoff, Roelof, Nelson, Jessica K., Kingma, Jenina, Scheij, Saskia, Moeton, Martina, Zelcer, Noam

“…Cholesterol metabolism is tightly regulated by transcriptional and post-transcriptional mechanisms. Accordingly, dysregulation of cholesterol metabolism is a…”
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Inactivation of the E3 Ubiquitin Ligase IDOL (Inducible Degrader of the Low-Density Lipoprotein Receptor) Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice by van Loon, Nienke M, Ottenhoff, Roelof, Kooijman, Sander, Moeton, Martina, Scheij, Saskia, Roscam Abbing, Reinout L.P, Gijbels, Marion J.J, Levels, Johannes H.M, Sorrentino, Vincenzo, Berbée, Jimmy F.P, Rensen, Patrick C.N, Zelcer, Noam

“…OBJECTIVE—The E3 ubiquitin ligase IDOL (inducible degrader of the LDLR [LDL (low-density lipoprotein) receptor]) is a post-transcriptional regulator of LDLR…”
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A haploid mammalian genetic screen identifies UBXD8 as a key determinant of sterol-stimulated degradation of HMGCR and cholesterol synthesis by Loregger-Wiesmann, Anke, Raaben, Matthijs, Tan, Josephine, Scheij, Saskia, Moeton, Martina, Gelberg, Hela, Stickel, Elmer, Roitelman, Joseph, Brummelkamp, Thijn, Zelcer, Noam

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Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer by Alioui, Anthony, Dufour, Julie, Leoni, Valerio, Loregger, Anke, Moeton, Martina, Iuliano, Luigi, Zerbinati, Chiara, Septier, Amandine, Val, Pierre, Fouache, Allan, Russo, Vincenzo, Volle, David H, Lobaccaro, Jean-Marc A, Zelcer, Noam, Baron, Silvère

“…Advanced prostate cancer (PCa) is a clinical challenge as no curative therapeutic is available. In this context, a better understanding of metastasis and…”
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GFAPδ/GFAPα ratio directs astrocytoma gene expression towards a more malignant profile by Stassen, Oscar M J A, van Bodegraven, Emma J, Giuliani, Fabrizio, Moeton, Martina, Kanski, Regina, Sluijs, Jacqueline A, van Strien, Miriam E, Kamphuis, Willem, Robe, Pierre A J, Hol, Elly M

“…Astrocytomas are the most common malignant brain tumours and are to date incurable. It is unclear how astrocytomas progress into higher malignant grades. The…”
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Serotonin transporter gene promoter polymorphisms modify the association between paroxetine serotonin transporter occupancy and clinical response in major depressive disorder by Ruhé, Henricus G, Ooteman, Wendy, Booij, Jan, Michel, Martin C, Moeton, Martina, Baas, Frank, Schene, Aart H

“…BACKGROUNDIn major depressive disorder, selective serotonin reuptake inhibitors target the serotonin transporter (SERT). Their response rates (30–50%) are…”
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The adult human subventricular zone: partial ependymal coverage and proliferative capacity of cerebrospinal fluid by de Sonnaville, Sophia F A M, van Strien, Miriam E, Middeldorp, Jinte, Sluijs, Jacqueline A, van den Berge, Simone A, Moeton, Martina, Donega, Vanessa, van Berkel, Annemiek, Deering, Tasmin, De Filippis, Lidia, Vescovi, Angelo L, Aronica, Eleonora, Glass, Rainer, van de Berg, Wilma D J, Swaab, Dick F, Robe, Pierre A, Hol, Elly M

“…Abstract Neurogenesis continues throughout adulthood in specialized regions of the brain. One of these regions is the subventricular zone. During brain…”
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