Search Results - "Moerman, D G"

Gene expression profiling of cells, tissues, and developmental stages of the nematode C. elegans by McKay, S J, Johnsen, R, Khattra, J, Asano, J, Baillie, D L, Chan, S, Dube, N, Fang, L, Goszczynski, B, Ha, E, Halfnight, E, Hollebakken, R, Huang, P, Hung, K, Jensen, V, Jones, S J M, Kai, H, Li, D, Mah, A, Marra, M, McGhee, J, Newbury, R, Pouzyrev, A, Riddle, D L, Sonnhammer, E, Tian, H, Tu, D, Tyson, J R, Vatcher, G, Warner, A, Wong, K, Zhao, Z, Moerman, D G

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Products of the unc-52 gene in Caenorhabditis elegans are homologous to the core protein of the mammalian basement membrane heparan sulfate proteoglycan by ROGALSKI, T. M, WILLIAMS, B. D, MULLEN, G. P, MOERMAN, D. G

“…Mutations in the unc-52 gene of Caenorhabditis elegans affect attachment of the myofilament lattice to the muscle cell membrane. Here, we demonstrate that the…”
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Mutations in the unc-52 Gene Responsible for Body Wall Muscle Defects in Adult Caenorhabditis elegans Are Located in Alternatively Spliced Exons by Rogalski, T. M, Gilchrist, E. J, Mullen, G. P, Moerman, D. G

“…The unc-52 gene in Caenorhabditis elegans produces several large proteins that function in the basement membrane underlying muscle cells. Mutations in this…”
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Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans by Benian, Guy M, Kiff, Jane E, Neckelmann, Nicolas, Moerman, Donald G, Waterston, Robert H

“…The Caenorhabditis elegans gene unc-22 encodes a very large muscle protein, called twitchin, which consists of a protein kinase domain and several copies of…”
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Production of antisense RNA leads to effective and specific inhibition of gene expression in C. elegans muscle by FIRE, A, ALBERTSON, D, HARRISON, S. W, MOERMAN, D. G

“…We have used an antisense strategy to effectively disrupt the expression of two genes encoding myofilament proteins present in C. elegans body wall muscles…”
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Functional Genomics of the Cilium, a Sensory Organelle by Blacque, Oliver E., Perens, Elliot A., Boroevich, Keith A., Inglis, Peter N., Li, Chunmei, Warner, Adam, Khattra, Jaswinder, Holt, Rob A., Ou, Guangshuo, Mah, Allan K., McKay, Sheldon J., Huang, Peter, Swoboda, Peter, Jones, Steve J.M., Marra, Marco A., Baillie, David L., Moerman, Donald G., Shaham, Shai, Leroux, Michel R.

“…Cilia and flagella play important roles in many physiological processes, including cell and fluid movement, sensory perception, and development [ 1]. The…”
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C. elegans PAT-4/ILK Functions as an Adaptor Protein within Integrin Adhesion Complexes by Mackinnon, A.Craig, Qadota, Hiroshi, Norman, Kenneth R., Moerman, Donald G., Williams, Benjamin D.

“…Background: Mammalian integrin-linked kinase (ILK) was identified in a yeast two-hybrid screen for proteins binding the integrin β1 subunit cytoplasmic domain…”
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Molecular Cloning of the Muscle Gene unc-22 in Caenorhabditis elegans by Tc1 Transposon Tagging by Moerman, D. G., Benian, G. M., Waterston, R. H.

“…The previously described mutator system of Caenorhabditis elegans var. Bergerac has as one of its targets unc-22, a previously uncloned gene on chromosome IV…”
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Identification and intracellular localization of the unc-22 gene product of Caenorhabditis elegans by MOERMAN, D. G, BENIAN, G. M, BARSTEAD, R. J, SCHRIEFER, L. A, WATERSTON, R. H

“…The unc-22 gene is one of a set of genes identified using classical genetics that affect muscle structure and function in the free-living nematode…”
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Analysis of a Mutator Activity Necessary for Germline Transposition and Excision of Tc1 Transposable Elements in Caenorhabditis elegans by Mori, I, Moerman, D. G, Waterston, R. H

“…The Tc1 transposable element family of the nematode Caenorhabditis elegans consists primarily of 1.6-kb size elements. This uniformity of size is in contrast…”
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Mutations in the sup-38 Gene of Caenorhabditis elegans Suppress Muscle-Attachment Defects in unc-52 Mutants by Gilchrist, E. J, Moerman, D. G

“…Mutations in the unc-52 locus of Caenorhabditis elegans have been classified into three different groups based on their complex pattern of complementation…”
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C. elegans PAT-6/Actopaxin Plays a Critical Role in the Assembly of Integrin Adhesion Complexes In Vivo by Lin, Xinyi, Qadota, Hiroshi, Moerman, Donald G., Williams, Benjamin D.

“…Background: The novel focal adhesion protein actopaxin includes tandem unconventional calponin homology (CH) domains and a less well-conserved N-terminal…”
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The UNC-112 Gene in Caenorhabditis elegans Encodes a Novel Component of Cell-Matrix Adhesion Structures Required for Integrin Localization in the Muscle Cell Membrane by Rogalski, Teresa M., Mullen, Gregory P., Gilbert, Mary M., Williams, Benjamin D., Moerman, Donald G.

“…Embryos homozygous for mutations in the unc-52, pat-2, pat-3, and unc-112 genes of C. elegans exhibit a similar Pat phenotype. Myosin and actin are not…”
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SPONTANEOUS UNSTABLE UNC-22 IV MUTATIONS IN C. ELEGANS VAR. BERGERAC by Moerman, D. G, Waterston, R. H

“…This paper describes a mutator system in the nematode Caenorhabditis elegans var. Bergerac for the gene unc-22. Of nine C. elegans and two C. briggsae strains…”
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α Spectrin Is Essential for Morphogenesis and Body Wall Muscle Formation in Caenorhabditis elegans by Norman, Kenneth R., Moerman, Donald G.

“…A common feature of multicellular animals is the ubiquitous presence of the spectrin cytoskeleton. Although discovered over 30 yr ago, the function of spectrin…”
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A Conserved LIM Protein That Affects Muscular Adherens Junction Integrity and Mechanosensory Function in Caenorhabditis elegans by Hobert, Oliver, Moerman, Donald G., Clark, Kathleen A., Beckerle, Mary C., Ruvkun, Gary

“…We describe here the molecular and functional characterization of the Caenorhabditis elegans unc-97 gene, whose gene product constitutes a novel component of…”
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Transposable element Tc1 of Caenorhabditis elegans recognizes specific target sequences for integration by Mori, I, Benian, G.M, Moerman, D.G, Waterston, R.H

“…The frequency of movement of Tc1, a 1.6-kilobase transposable element in the nematode Caenorhabditis elegans, is under genetic control, and Tc1 insertion sites…”
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Critical Residues of the Caenorhabditis elegans unc-2 Voltage-Gated Calcium Channel That Affect Behavioral and Physiological Properties by Mathews, Eleanor A, Garcia, Esperanza, Santi, Celia M, Mullen, Gregory P, Thacker, Colin, Moerman, Donald G, Snutch, Terrance P

“…The Caenorhabditis elegans unc-2 gene encodes a voltage-gated calcium channel alpha1 subunit structurally related to mammalian dihydropyridine-insensitive…”
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Identification of a novel Cdc42 GEF that is localized to the PAT-3-mediated adhesive structure by Hikita, Takao, Qadota, Hiroshi, Tsuboi, Daisuke, Taya, Shinichiro, Moerman, Donald G., Kaibuchi, Kozo

“…In the model organism Caenorhabditis elegans, UNC-112 is colocalized with PAT-3/β-integrin and is a critical protein in the formation of PAT-3-mediated…”
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The let-268 Locus of Caenorhabditis elegans Encodes a Procollagen Lysyl Hydroxylase That Is Essential for Type IV Collagen Secretion by Norman, Kenneth R., Moerman, Donald G.

“…Basement membranes are thin sheets of specialized extracellular matrix molecules that are important for supplying mechanical support and for providing an…”
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