Human Coronavirus 229E: Receptor Binding Domain and Neutralization by Soluble Receptor at 37 degree C

Human Coronavirus 229E: Receptor Binding Domain and Neutralization by Soluble Receptor at 37 degree C

Truncated human coronavirus HCoV-229E spike glycoproteins containing amino acids 407 to 547 bound to purified, soluble virus receptor, human aminopeptidase N (hAPN). Soluble hAPN neutralized the infectivity of HCoV-229E virions at 37 degree C, but not 4 degree C. Binding of hAPN may therefore trigge...

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Bibliographic Details
Published in:Journal of virology Vol. 77; no. 7; pp. 4435 - 4438
Main Authors: Breslin, J J, Moerk, I, Smith, M K, Vogel, L K, Hemmila, E M, Bonavia, A, Talbot, P J, Sjoestroem, H, Noren, O, Holmes, K V
Format: Journal Article
Language:English
Published: 01-04-2003
Online Access:Get full text
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Summary:Truncated human coronavirus HCoV-229E spike glycoproteins containing amino acids 407 to 547 bound to purified, soluble virus receptor, human aminopeptidase N (hAPN). Soluble hAPN neutralized the infectivity of HCoV-229E virions at 37 degree C, but not 4 degree C. Binding of hAPN may therefore trigger conformational changes in the viral spike protein at 37 degree C that facilitate virus entry.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0022-538X
DOI:10.1128/JVI.77.7.4435-4438.2003