Search Results - "Moen, Robert C"

Compacted DNA nanoparticles administered to the nasal mucosa of cystic fibrosis subjects are safe and demonstrate partial to complete cystic fibrosis transmembrane regulator reconstitution by Konstan, Michael W, Davis, Pamela B, Wagener, Jeffrey S, Hilliard, Kathleen A, Stern, Robert C, Milgram, Laura J H, Kowalczyk, Tomasz H, Hyatt, Susannah L, Fink, Tamara L, Gedeon, Christopher R, Oette, Sharon M, Payne, Jennifer M, Muhammad, Osman, Ziady, Assem G, Moen, Robert C, Cooper, Mark J

“…A double-blind, dose escalation gene transfer trial was conducted in subjects with cystic fibrosis (CF), among whom placebo (saline) or compacted DNA was…”
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Nanoparticles of Compacted DNA Transfect Postmitotic Cells by Liu, Ge, Li, DeShan, Pasumarthy, Murali K., Kowalczyk, Tomasz H., Gedeon, Christopher R., Hyatt, Susannah L., Payne, Jennifer M., Miller, Timothy J., Brunovskis, Peter, Fink, Tamara L., Muhammad, Osman, Moen, Robert C., Hanson, Richard W., Cooper, Mark J.

“…Charge-neutral DNA nanoparticles have been developed in which single molecules of DNA are compacted to their minimal possible size. We speculated that the…”
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Transfection of airway epithelium by stable PEGylated poly-l-lysine DNA nanoparticles in vivo by Ziady, Assem-Galal, Gedeon, Christopher R, Miller, Timothy, Quan, William, Payne, Jennifer M, Hyatt, Susannah L, Fink, Tamara L, Muhammad, Osman, Oette, Sharon, Kowalczyk, Tomasz, Pasumarthy, Murali K, Moen, Robert C, Cooper, Mark J, Davis, Pamela B

“…DNA can be compacted using polyethylene glycol-substituted poly-l-lysine into discrete unimolecular (with respect to DNA) nanoparticles with minor diameter <20…”
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Optimization of hCFTR Lung Expression in Mice Using DNA Nanoparticles by Padegimas, Linas, Kowalczyk, Tomasz H, Adams, Sam, Gedeon, Chris R, Oette, Sharon M, Dines, Karla, Hyatt, Susannah L, Sesenoglu-Laird, Ozge, Tyr, Olena, Moen, Robert C, Cooper, Mark J

“…Efficient and prolonged human cystic fibrosis transmembrane conductance regulator (hCFTR) expression is a major goal for cystic fibrosis (CF) lung therapy. A…”
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Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency by Kohn, Donald B, Weinberg, Kenneth I, Nolta, Jan A, Heiss, Linda N, Lenarsky, Carl, Crooks, Gay M, Hanley, Mary E, Annett, Geralyn, Brooks, Judith S, El-Khoureiy, Anthony, Lawrence, Kim, Wells, Susie, Moen, Robert C, Bastian, John, Williams-Herman, Debora E, Elder, Melissa, Wara, Diane, Bowen, Thomas, Hershfield, Michael S, Mullen, Craig A, Blaese, R. Michael, Parkman, Robertson

“…Haematopoietic stem cells in umbilical cord blood are an attractive target for gene therapy of inborn errors of metabolism. Three neonates with severe combined…”
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Minimal toxicity of stabilized compacted DNA nanoparticles in the murine lung by Ziady, Assem-Galal, Gedeon, Christopher R, Muhammad, Osman, Stillwell, Virginia, Oette, Sharon M, Fink, Tamara L, Quan, Will, Kowalczyk, Tomasz H, Hyatt, Susannah L, Payne, Jennifer, Peischl, Angela, Seng, J.E, Moen, Robert C, Cooper, Mark J, Davis, Pamela B

“…Nanoparticles containing DNA compacted with poly-l-lysine modified on an N-terminal cysteine with polyethylene glycol can effectively transfect cells of the…”
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Correlation of procollagen mRNA levels in normal and transformed chick embryo fibroblasts with different rates of procollagen synthesis by Rowe, David W, Moen, Robert C, Davidson, Jeffrey M, Byers, Peter H, Bornstein, Paul, Palmiter, Richard D

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Retrovirally Marked CD34-Enriched Peripheral Blood and Bone Marrow Cells Contribute to Long-Term Engraftment After Autologous Transplantation by Dunbar, Cynthia E., Cottier-Fox, Michelle, O'Shaughnessy, Joyce A., Doren, Sandra, Carter, Charles, Berenson, Ronald, Brown, Sherri, Moen, Robert C., Greenblatt, Jay, Stewart, F.Marc, Leitman, Susan F., Wilson, Wyndham H., Cowan, Kenneth, Young, Neal S., Nienhuis, Arthur W.

“…We report here on a preliminary human autologous transplantation study of retroviral gene transfer to bone marrow (BM) and peripheral blood (PB)-derived…”
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Gene-marking to trace origin of relapse after autologous bone-marrow transplantation by Brenner, M K, Rill, D R, Moen, R C, Krance, R A, Mirro, Jr, J, Anderson, W F, Ihle, J N

“…Bone marrow harvested for autologous bone-marrow transplantation may contain residual malignant cells even when it is judged to be in remission. Genetic…”
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Direct demonstration that autologous bone marrow transplantation for solid tumors can return a multiplicity of tumorigenic cells by RILL, D. R, SANTANA, V. M, ROBERTS, W. M, NILQON, T, BOWMAN, L. C, KRANCE, R. A, HESLOP, H. E, MOEN, R. C, IHLE, J. N, BRENNER, M. K

“…Patients with solid tumors are increasingly being treated by autologous bone marrow transplantation (BMT). Although response rates appear to be increased,…”
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In utero gene therapy: transfer and long-term expression of the bacterial neo(r) gene in sheep after direct injection of retroviral vectors into preimmune fetuses by Porada, C D, Tran, N, Eglitis, M, Moen, R C, Troutman, L, Flake, A W, Zhao, Y, Anderson, W F, Zanjani, E D

“…We investigated whether directly injecting retroviral vectors into preimmune fetuses could result in the transfer and long-term expression of exogenous genes…”
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501. Aerosols of compacted DNA nanoparticles retain structural integrity and biological activity by Oette, Sharon M, Gedeon, Christopher R, Kowalczyk, Tomasz H, Fink, Tamara L, Hyatt, Susannah L, Moen, Robert C, Cooper, Mark J

“…Compacted DNA nanoparticles consist of single molecules of plasmid DNA condensed with polyethylene glycol (PEG)-substituted lysine polymers. Using a 30-mer…”
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849. CD Spectra of Compacted DNA Nanoparticles Demonstrate a Unique DNA Structure by Kowalczyk, Tomasz H, Gedeon, Christopher R, Klepcyk, Patrick J, Oette, Sharon M, Fink, Tamara L, Moen, Robert C, Cooper, Mark J

“…In order to evaluate the usefulness of circular dichroism (CD) spectroscopy as a quality control assay in manufacturing DNA nanoparticles, well-characterized…”
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In vivo trafficking of adoptively transferred interleukin-2 expanded tumor-infiltrating lymphocytes and peripheral blood lymphocytes. Results of a double gene marking trial by Economou, J S, Belldegrun, A S, Glaspy, J, Toloza, E M, Figlin, R, Hobbs, J, Meldon, N, Kaboo, R, Tso, C L, Miller, A, Lau, R, McBride, W, Moen, R C

“…Adoptive immunotherapy with tumor-infiltrating lymphocytes (TIL) and IL-2 appears to produce dramatic regressions in patients with metastatic melanoma and…”
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Amphotropic murine leukemia retrovirus is not an acute pathogen for primates by Cornetta, K, Moen, R C, Culver, K, Morgan, R A, McLachlin, J R, Sturm, S, Selegue, J, London, W, Blaese, R M, Anderson, W F

“…The in vivo fate of amphotropic murine leukemia retrovirus was studied in five rhesus monkeys. Retrovirus infused intravenously into 3 normal animals and 1…”
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Report to the NIH Recombinant DNA Advisory Committee on murine replication-competent retrovirus (RCR) assays (February 17, 1993) by Anderson, W F, McGarrity, G J, Moen, R C

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Gene therapy of cancer: a pilot study of IL-4-gene-modified fibroblasts admixed with autologous tumor to elicit an immune response by Lotze, M T, Rubin, J T, Carty, S, Edington, H, Ferson, P, Landreneau, R, Pippin, B, Posner, M, Rosenfelder, D, Watson, C

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Gene marking and autologous bone marrow transplantation by Brenner, M K, Rill, D R, Moen, R C, Krance, R A, Heslop, H E, Mirro, Jr, J, Anderson, W F, Ihle, J N

“…If residual cancer cells in harvested bone marrow could be marked and subsequently detected in patients at relapse, valuable information would be obtained…”
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Transfer of the ADA gene into bone marrow cells and peripheral blood lymphocytes for the treatment of patients affected by ADA-deficient SCID by Bordignon, C, Mavilio, F, Ferrari, G, Servida, P, Ugazio, A G, Notarangelo, L D, Gilboa, E, Rossini, S, O'Reilly, R J, Smith, C A

“…Severe combined immunodeficiency (SCID) caused by deficiency of the enzyme adenosine deaminase (ADA) is the first genetic disorder considered for human somatic…”
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Transduction of Human Melanoma Cell Lines With the Human Interleukin-7 Gene Using Retroviral-Mediated Gene Transfer: Comparison of Immunologic Properties With Interleukin-2 by Miller, Alexander R., McBride, William H., Dubinett, Steven M., Dougherty, Graeme J., Thacker, J. Dean, Shau, Hungyi, Kohn, Donald B., Moen, Robert C., Walker, Michael J., Chiu, Robert, Schuck, Beatrice L., Rosenblatt, Joseph A., Huang, Min, Dhanani, Shawkat, Rhoades, Kristina, Economou, James S.

“…Two human melanoma cell lines were transduced with the human interleukin (IL)-7 and IL-2 genes using retroviral-mediated gene transfer. Stable, high-level…”
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