Search Results - "Moelling, K"

The Bcr Kinase Downregulates Ras Signaling by Phosphorylating AF-6 and Binding to Its PDZ Domain by Radziwill, G., Erdmann, R. A., Margelisch, U., Moelling, K.

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The PDZ protein erbin modulates beta-catenin-dependent transcription by Ress, A, Moelling, K

“…Erbin is a member of the leucine-rich repeat and PDZ domain family that can regulate proliferation, differentiation and cell adhesion. As a binding partner of…”
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Specific binding of HIV‐1 nucleocapsid protein to PSI RNA in vitro requires N‐terminal zinc finger and flanking basic amino acid residues by Dannull, J., Surovoy, A., Jung, G., Moelling, K.

“…The nucleocapsid (NC) protein of human immunodeficiency virus HIV‐1 (NCp7) is responsible for packaging the viral RNA by recognizing a packaging site (PSI) on…”
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Naked DNA--the poor man's gene therapy? by Moelling, K

“…Vaccination with naked DNA was originally designed as a control experiment to test liposomes as DNA carriers. It proved to be a surprise that DNA alone was…”
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Relationship between retroviral replication and RNA interference machineries by Moelling, K, Matskevich, A, Jung, J-S

“…Small interfering RNAs (siRNAs) associated with gene silencing are cellular defense mechanisms against invading viruses. The viruses fight back by suppressors…”
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Prevention of angiogenesis by naked DNA IL-12 gene transfer: angioprevention by immunogene therapy by MORINI, M, ALBINI, A, LORUSSO, G, MOELLING, K, LU, B, CILLI, M, FERRINI, S, NOONAN, D. M

“…IL-12 is thought to induce a cytokine cascade with antiangiogenic effects mediated by IFN-gamma and angiostatic CXCR3 chemokine ligands. Naked DNA…”
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The Combined Action of IL-15 and IL-12 Gene Transfer Can Induce Tumor Cell Rejection Without T and NK Cell Involvement by Di Carlo, Emma, Comes, Alberto, Basso, Stefania, De Ambrosis, Alessandro, Meazza, Raffaella, Musiani, Piero, Moelling, Karin, Albini, Adriana, Ferrini, Silvano

“…The cooperative antitumor effects of IL-12 and IL-15 gene transfer were studied in the N592 MHC class I-negative small cell lung cancer cell line…”
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Clinical Efficacy by Intratumoral Injection of DNA Encoding Human Interleukin-12 in Metastatic Melanoma Patients by Moelling, K, Pavlovic, J, Elzaouk, L, Heinzerling, L

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Phase I clinical trial with HIV-1 gp160 plasmid vaccine in HIV-1-infected asymptomatic subjects by WEBER, R, BOSSART, W, CONE, R, LUETHY, R, MOELLING, K

“…The aim of the study was to investigate the safety of an HIV-1 gp160 plasmid vaccine. Four asymptomatic HIV-1-infected subjects with CD4+ lymphocyte counts…”
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Intradermal delivery of interleukin-12 plasmid DNA by in vivo electroporation by Heller, R, Schultz, J, Lucas, M L, Jaroszeski, M J, Heller, L C, Gilbert, R A, Moelling, K, Nicolau, C

“…Gene therapy depends on safe and efficient gene delivery. The skin is an attractive target for gene delivery because of its accessibility. Recently, in vivo…”
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Identification and characterization of HIV‐specific RNase H by monoclonal antibody by Hansen, J., Schulze, T., Mellert, W., Moelling, K.

“…Human immune deficiency virus (HIV) replicates by conversion of the RNA genome into the double‐stranded DNA provirus. The reverse transcriptase is not the only…”
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Mutations of basic amino acids of NCp7 of human immunodeficiency virus type 1 affect RNA binding in vitro by Schmalzbauer, E, Strack, B, Dannull, J, Guehmann, S, Moelling, K

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Self-inactivation of HIV by its own RT/RNase H by Moelling, K, Matskevich, A, Elzaouk, L, Heinrich, J, Jung, JS, Kwok, T, Mathur, S

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Silencing of HIV RNA by a Hairpin-loop DNA by Moelling, K, Abels, S, Jendis, J, Heinrich, J, Ziogas, A, Matskevich, A

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Mutations within the RNase H Domain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Abolish Virus Infectivity by Tisdale, Margaret, Schulze, Thomas, Larder, Brendan A, Moelling, Karin

“…1 Molecular Sciences Department, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS U.K. and 2 Max-Planck-Institut fuer Molekulare Genetik,…”
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p53 tumour suppressor gene expression in pancreatic neuroendocrine tumour cells by Bartz, C, Ziske, C, Wiedenmann, B, Moelling, K

“…Neuroendocrine pancreatic tumours grow slower and metastasise later than ductal and acinar carcinomas. The expression of the p53 tumour suppressor gene in…”
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Induction of long-lasting cytokine effect by injection of IL-12 encoding plasmid DNA by Schultz, J, Heinzerling, L, Pavlovic, J, Moelling, K

“…We have recently demonstrated that DNA coding for both subunits of the murine IL-12 heterodimer exhibits a strong antimetastatic effect against B16-melanoma in…”
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RNase H activity associated with bacterially expressed reverse transcriptase of human T-cell lymphotropic virus III/lymphadenopathy-associated virus by Hansen, J, Schulze, T, Moelling, K

“…The reverse transcriptase polymerase of the human T-cell lymphotropic virus/lymphadenopathy-associated virus has been cloned into an expression vector and…”
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Inhibition of human immunodeficiency virus type 1 RNase H by sulfated polyanions by MOELLING, K, SCHULZE, T, DIRINGER, H

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Reduced melanoma tumor formation in mice immunized with DNA expressing the melanoma-specific antigen gp100/pmel17 by NAWRATH, M, PAVLOVIC, J, DUMMET, R, SCHULTZ, J, STRACK, B, HEINRICH, J, MOELLING, K

“…Plasmid DNA encoding gene products of viruses or other pathogens has recently been applied by intramuscular injection as a novel type of vaccine. It can induce…”
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