Search Results - "Moeller, Lars C."

Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature by Flamant, Frédéric, Cheng, Sheue-Yann, Hollenberg, Anthony N., Moeller, Lars C., Samarut, Jacques, Wondisford, Fredric E., Yen, Paul M., Refetoff, Samuel

“…Current literature makes a distinction between two pathways for thyroid hormone signaling: genomic and nongenomic. However, this classification is a source of…”
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NGS based identification of mutational hotspots for targeted therapy in anaplastic thyroid carcinoma by Tiedje, Vera, Ting, Saskia, Herold, Thomas, Synoracki, Sarah, Latteyer, Soeren, Moeller, Lars C, Zwanziger, Denise, Stuschke, Martin, Fuehrer, Dagmar, Schmid, Kurt Werner

“…Anaplastic thyroid carcinoma (ATC) represents one of the most aggressive carcinomas with no consistent survival benefit when treated with conventional…”
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Generation of THRB-GS(E125G_G126S) and THRB-KO human iPSC lines to study noncanonical thyroid hormone signalling by Ludwik, Katarzyna A., Jahn, Regina, Schörding, Ann-Kathrin, Moeller, Lars C., Stachelscheid, Harald

“…THRB is a nuclear receptor, regulating gene expression dependent on thyroid hormone (TH) binding. The same receptor mediates signaling pathway activation in…”
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Evolution of non-thyroidal illness syndrome in acute decompensation of liver cirrhosis and acute-on-chronic liver failure by Langer, Mona-May, Bauschen, Alina, Guckenbiehl, Sabrina, Klauss, Sarah, Lutz, Teresa, Denk, Gerald, Zwanziger, Denise, Moeller, Lars C, Lange, Christian M

“…Non-thyroidal illness syndrome (NTIS) is frequent in critically ill patients and associated with adverse outcomes. We aimed to characterize the evolution of…”
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Cardioprotection by Hypothyroidism Is Not Mediated by Favorable Hemodynamics—Role of Canonical Thyroid Hormone Receptor Alpha Signaling by Pape, Janina, Kerp, Helena, Lieder, Helmut R., Geist, Daniela, Hönes, Georg Sebastian, Moeller, Lars C., Kleinbongard, Petra, Führer, Dagmar

“…Hypothyroidism has been shown to reduce infarct size in rats, but the underlying mechanisms are unclear. We used isolated pressure-constant perfused hearts of…”
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Clinical Characterization of the Pheochromocytoma and Paraganglioma Susceptibility Genes SDHA, TMEM127, MAX, and SDHAF2 for Gene-Informed Prevention by Bausch, Birke, Schiavi, Francesca, Ni, Ying, Welander, Jenny, Patocs, Attila, Ngeow, Joanne, Wellner, Ulrich, Malinoc, Angelica, Taschin, Elisa, Barbon, Giovanni, Lanza, Virginia, Söderkvist, Peter, Stenman, Adam, Larsson, Catharina, Svahn, Fredrika, Chen, Jin-Lian, Marquard, Jessica, Fraenkel, Merav, Walter, Martin A, Peczkowska, Mariola, Prejbisz, Aleksander, Jarzab, Barbara, Hasse-Lazar, Kornelia, Petersenn, Stephan, Moeller, Lars C, Meyer, Almuth, Reisch, Nicole, Trupka, Arnold, Brase, Christoph, Galiano, Matthias, Preuss, Simon F, Kwok, Pingling, Lendvai, Nikoletta, Berisha, Gani, Makay, Özer, Boedeker, Carsten C, Weryha, Georges, Racz, Karoly, Januszewicz, Andrzej, Walz, Martin K, Gimm, Oliver, Opocher, Giuseppe, Eng, Charis, Neumann, Hartmut P H

“…Effective cancer prevention is based on accurate molecular diagnosis and results of genetic family screening, genotype-informed risk assessment, and tailored…”
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Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document by Jonklaas, Jacqueline, Bianco, Antonio C., Cappola, Anne R., Celi, Francesco S., Fliers, Eric, Heuer, Heike, McAninch, Elizabeth A., Moeller, Lars C., Nygaard, Birte, Sawka, Anna M., Watt, Torquil, Dayan, Colin M.

“…Background: Fourteen clinical trials have not shown a consistent benefit of combination therapy with levothyroxine (LT4) and liothyronine (LT3). Despite the…”
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Thyroid hormones regulate Zfp423 expression in regionally distinct adipose depots through direct and cell-autonomous action by Roth, Lisa, Johann, Kornelia, Hönes, Georg Sebastian, Oelkrug, Rebecca, Wagner, Leonie, Hoffmann, Anne, Krohn, Knut, Moeller, Lars C., Weiner, Juliane, Heiker, John T., Klöting, Nora, Tönjes, Anke, Stumvoll, Michael, Blüher, Matthias, Mittag, Jens, Krause, Kerstin

“…The hypothalamic pituitary thyroid axis is a major regulator of many differentiation processes, including adipose tissue. However, it remains unclear whether…”
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Mutations in SECISBP2 result in abnormal thyroid hormone metabolism by Schomburg, Lutz, Liao, Xiao-Hui, Majed, Fathia Abdul, Abdullah, Mohamed S Y, Refetoff, Samuel, Boran, Gerard, Dumitrescu, Alexandra M, Lado-Abeal, Joaquin, Moeller, Lars C, Weiss, Roy E

“…Incorporation of selenocysteine (Sec), through recoding of the UGA stop codon, creates a unique class of proteins. Mice lacking tRNASec die in utero, but the…”
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Lack of canonical thyroid hormone receptor α signaling changes regulatory T cell phenotype in female mice by Wenzek, Christina, Siemes, Devon, Hönes, G. Sebastian, Pastille, Eva, Härting, Nina, Kaiser, Frank, Moeller, Lars C., Engel, Daniel R., Westendorf, Astrid M., Führer, Dagmar

“…The immune system has emerged as an important target of thyroid hormones (THs); however, the role of TH in T cells has so far remained elusive. In this study,…”
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Transcriptional regulation by nonclassical action of thyroid hormone by Moeller, Lars C, Broecker-Preuss, Martina

“…Thyroid hormone (TH) is essential for normal development, growth and metabolism. Its effects were thought to be principally mediated through triiodothyronine…”
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Translational perspectives from TSHR, MCT8 and TRα research by Moeller, Lars C.

“…In 2022, the activation mechanism of TSH receptor (TSHR) by TSH and autoantibodies was demonstrated, monocarboxylate transporter 8 (MCT8) deficiency was…”
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Higher Thyroid-Stimulating Hormone, Triiodothyronine and Thyroxine Values Are Associated with Better Outcome in Acute Liver Failure by Anastasiou, Olympia, Sydor, Svenja, Sowa, Jan-Peter, Manka, Paul, Katsounas, Antonios, Syn, Wing-Kin, Führer, Dagmar, Gieseler, Robert K, Bechmann, Lars P, Gerken, Guido, Moeller, Lars C, Canbay, Ali

“…Changes in thyroid hormone levels, mostly as non-thyroidal illness syndrome (NTIS), have been described in many diseases. However, the relationship between…”
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Thyroid hormone, thyroid hormone receptors, and cancer: a clinical perspective by Moeller, Lars C, Führer, Dagmar

“…Thyroid hormones (THs) may play a role in diseases other than hyper- and hypothyroidism. Several lines of evidence suggest tumor-promoting effects of TH and TH…”
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Metformin improves polycystic ovary syndrome symptoms irrespective of pre-treatment insulin resistance by Tan, Susanne, Hahn, Susanne, Benson, Sven, Dietz, Tiina, Lahner, Harald, Moeller, Lars C, Schmidt, Markus, Elsenbruch, Sigrid, Kimmig, Rainer, Mann, Klaus, Janssen, Onno E

“…AbstractObjectiveInsulin resistance (IR) and obesity are common features of the polycystic ovary syndrome (PCOS). Insulin-sensitizing agents have been shown to…”
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Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document by Jonklaas, Jacqueline, Bianco, Antonio C, Cappola, Anne R, Celi, Francesco S, Fliers, Eric, Heuer, Heike, McAninch, Elizabeth A, Moeller, Lars C, Nygaard, Birte, Sawka, Anna M, Watt, Torquil, Dayan, Colin M

“…Fourteen clinical trials have not shown a consistent benefit of combination therapy with levothyroxine (LT4) and liothyronine (LT3). Despite the publication of…”
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A Novel Mutation in the TBG Gene Producing Partial Thyroxine-Binding Globulin Deficiency (Glencoe) Identified in 2 Families by Pappa, Theodora, Moeller, Lars C., Edidin, Deborah V., Pannain, Silvana, Refetoff, Samuel

“…Background: Thyroxine-binding globulin (TBG) is the major thyroid hormone transport protein in serum. Located on the long arm of the X chromosome, TBG…”
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The interplay of thyroid hormones and the immune system – where we stand and why we need to know about it by Wenzek, Christina, Boelen, Anita, Westendorf, Astrid M, Engel, Daniel R, Moeller, Lars C, Führer, Dagmar

“…Over the past few years, growing evidence suggests direct crosstalk between thyroid hormones (THs) and the immune system. Components of the immune system were…”
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Combined PER2 and CRY1 expression predicts outcome in chronic lymphocytic leukemia by Eisele, Lewin, Prinz, Robert, Klein-Hitpass, Ludger, Nückel, Holger, Lowinski, Kerstin, Thomale, Jürgen, Moeller, Lars C., Dührsen, Ulrich, Dürig, Jan

“…The objective of this study was to confirm previous results regarding the differential expression and prognostic significance of the circadian gene CRY1 in…”
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Noncanonical Action of Thyroid Hormone Receptors α and β by Hönes, G Sebastian, Geist, Daniela, Moeller, Lars C

“…Thyroid hormone (TH) is essential for the regulation of many physiological processes, especially growth, organ development, energy metabolism and…”
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