Search Results - "Moehlman, Andrew T"

Mitochondrial Quality Control and Restraining Innate Immunity by Moehlman, Andrew T, Youle, Richard J

“…Maintaining mitochondrial health is essential for the survival and function of eukaryotic organisms. Misfunctioning mitochondria activate stress-responsive…”
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Loss of STING in parkin mutant flies suppresses muscle defects and mitochondria damage by Moehlman, Andrew T, Kanfer, Gil, Youle, Richard J

“…The early pathogenesis and underlying molecular causes of motor neuron degeneration in Parkinson's Disease (PD) remains unresolved. In the model organism…”
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Allnighter pseudokinase-mediated feedback links proteostasis and sleep in Drosophila by Shekhar, Shashank, Moehlman, Andrew T., Park, Brenden, Ewnetu, Michael, Tracy, Charles, Titos, Iris, Pawłowski, Krzysztof, Tagliabracci, Vincent S., Krämer, Helmut

“…In nervous systems, retrograde signals are key for organizing circuit activity and maintaining neuronal homeostasis. We identify the conserved Allnighter (Aln)…”
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The carcinine transporter CarT is required in Drosophila photoreceptor neurons to sustain histamine recycling by Stenesen, Drew, Moehlman, Andrew T, Krämer, Helmut

“…Synaptic transmission from Drosophila photoreceptors to lamina neurons requires recycling of histamine neurotransmitter. Synaptic histamine is cleared by…”
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Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration by Moehlman, Andrew T, Casey, Amanda K, Servage, Kelly, Orth, Kim, Krämer, Helmut

“…In response to environmental, developmental, and pathological stressors, cells engage homeostatic pathways to maintain their function. Among these pathways,…”
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Spermatogonial Gene Networks Selectively Couple to Glutathione and Pentose Phosphate Metabolism but Not Cysteine Biosynthesis by Prokai, David, Pudasaini, Ashutosh, Kanchwala, Mohammed, Moehlman, Andrew T., Waits, Alexandrea E., Chapman, Karen M., Chaudhary, Jaideep, Acevedo, Jesus, Keller, Patrick, Chao, Xing, Carr, Bruce R., Hamra, F. Kent

“…In adult males, spermatogonia maintain lifelong spermatozoa production for oocyte fertilization. To understand spermatogonial metabolism we compared gene…”
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Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies by Casey, Amanda K., Moehlman, Andrew T., Zhang, Junmei, Servage, Kelly A., Krämer, Helmut, Orth, Kim

“…Protein chaperones play a critical role in proteostasis. The activity of the major endoplasmic reticulum chaperone BiP (GRP78) is regulated by Fic-mediated…”
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Fic-mediated AMPylation tempers the unfolded protein response during physiological stress by Casey, Amanda K, Gray, Hillery F, Chimalapati, Suneeta, Hernandez, Genaro, Moehlman, Andrew T, Stewart, Nathan, Fields, Hazel A, Gulen, Burak, Servage, Kelly A, Stefanius, Karoliina, Blevins, Aubrie, Evers, Bret M, Krämer, Helmut, Orth, Kim

“…The proper balance of synthesis, folding, modification, and degradation of proteins, also known as protein homeostasis, is vital to cellular health and…”
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The glial sodium-potassium-2-chloride cotransporter is required for synaptic transmission in the Drosophila visual system by Stenesen, Drew, Moehlman, Andrew T., Schellinger, Jeffrey N., Rodan, Aylin R., Krämer, Helmut

“…The Drosophila Ncc69 gene encodes a Na + -K + -2Cl − -cotransporter (NKCC) that is critical for regulating intra- and extracellular ionic conditions in…”
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Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies by Casey, Amanda K., Moehlman, Andrew T., Zhang, Junmei, Servage, Kelly A., Krämer, Helmut, Orth, Kim

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Fic‐mediated deAMPylation is not dependent on homo‐dimerization and rescues toxic AMPylation in flies by Casey, Amanda K., Moehlman, Andrew T., Zhang, Junmei K., Servage, Kelly A., Krämer, Helmut K., Orth, Kim

“…Protein chaperones play a critical role in proteostasis. The activity of the major endoplasmic reticulum chaperone BiP (GRP78) is regulated by Fic‐mediated…”
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