Search Results - "Moedas, M."

Dihydrolipoamide dehydrogenase, pyruvate oxidation, and acetylation-dependent mechanisms intersecting drug iatrogenesis by Duarte, I. F., Caio, J., Moedas, M. F., Rodrigues, L. A., Leandro, A. P., Rivera, I. A., Silva, M. F. B.

“…In human metabolism, pyruvate dehydrogenase complex (PDC) is one of the most intricate and large multimeric protein systems representing a central hub for…”
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Advances in methods for characterization of hepatic urea cycle enzymatic activity in HepaRG cells using UPLC-MS/MS by Moedas, M.F., Adam, A.A.A., Farelo, M.A., IJlst, L., Chamuleau, R.A.F.M., Hoekstra, R., Wanders, R.J.A., Silva, M.F.B.

“…Current methodologies for the assessment of urea cycle (UC) enzymatic activity are insufficient to accurately evaluate this pathway in biological specimens…”
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NAD depletion and mitochondrial protein hyperacetylation: New insights on liver toxicity and drug-induced effects in vivo by Moedas, M., Van Chruchten, A., IJlst, L., Castro, R., Houtkooper, R.H., Wanders, R.J.A., Silva, M.F.B.

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Dihydrolipoamide dehydrogenase, pyruvate oxidation, and acetylation-dependent mechanisms intersecting drug iatrogenesis by Duarte, I. F., Caio, J., Moedas, M. F., Rodrigues, L. A., Leandro, A. P., Rivera, I. A., Silva, M. F. B.

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Mitochondrial targets in hyperammonemia: Addressing urea cycle function to improve drug therapies by Moedas, Marco F., Simões, Ricardo J.M., Silva, Margarida F.B.

“…[Display omitted] The urea cycle (UC) is a critically important metabolic process for the disposal of nitrogen (ammonia) produced by amino acids catabolism…”
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Pathogenic SLC25A26 variants impair SAH transport activity causing mitochondrial disease by Schober, Florian A, Tang, Jia Xin, Sergeant, Kate, Moedas, Marco F, Zierz, Charlotte M, Moore, David, Smith, Conrad, Lewis, David, Guha, Nishan, Hopton, Sila, Falkous, Gavin, Lam, Amanda, Pyle, Angela, Poulton, Joanna, Gorman, Gráinne S, Taylor, Robert W, Freyer, Christoph, Wredenberg, Anna

“…Abstract The SLC25A26 gene encodes a mitochondrial inner membrane carrier that transports S-adenosylmethionine (SAM) into the mitochondrial matrix in exchange…”
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Stable Isotope Labeling of Amino Acids in Flies (SILAF) Reveals Differential Phosphorylation of Mitochondrial Proteins Upon Loss of OXPHOS Subunits by Rosenberger, Florian A., Atanassov, Ilian, Moore, David, Calvo-Garrido, Javier, Moedas, Marco F., Wedell, Anna, Freyer, Christoph, Wredenberg, Anna

“…Drosophila melanogaster has been a workhorse of genetics and cell biology for more than a century. However, proteomic-based methods have been limited due to…”
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Severe congenital lactic acidosis and hypertrophic cardiomyopathy caused by an intronic variant in NDUFB7 by Correia, Sandrina P., Moedas, Marco F., Naess, Karin, Bruhn, Helene, Maffezzini, Camilla, Calvo‐Garrido, Javier, Lesko, Nicole, Wibom, Rolf, Schober, Florian A., Jemt, Anders, Stranneheim, Henrik, Freyer, Christoph, Wedell, Anna, Wredenberg, Anna

“…Mutations in structural subunits and assembly factors of complex I of the oxidative phosphorylation system constitute the most common cause of mitochondrial…”
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The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters by Rosenberger, Florian A, Moore, David, Atanassov, Ilian, Moedas, Marco F, Clemente, Paula, Végvári, Ákos, Fissi, Najla El, Filograna, Roberta, Bucher, Anna-Lena, Hinze, Yvonne, The, Matthew, Hedman, Erik, Chernogubova, Ekaterina, Begzati, Arjana, Wibom, Rolf, Jain, Mohit, Nilsson, Roland, Käll, Lukas, Wedell, Anna, Freyer, Christoph, Wredenberg, Anna

“…Induction of the one-carbon cycle is an early hallmark of mitochondrial dysfunction and cancer metabolism. Vital intermediary steps are localized to…”
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