Search Results - "Moebius, F F"

Purification, Molecular Cloning, and Expression of the Mammalian sigma1-Binding Site by Hanner, Markus, Moebius, Fabian F., Flandorfer, Astrid, Knaus, Hans-Günther, Striessnig, Jörg, Kempner, Ellis, Glossmann, Hartmut

“…Sigma-ligands comprise several chemically unrelated drugs such as haloperidol, pentazocine, and ditolyl-guanidine, which bind to a family of low molecular mass…”
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Increases in fire risk due to warmer summer temperatures and wildland urban interface changes do not necessarily lead to more fires by Fox, D.M., Martin, N., Carrega, P., Andrieu, J., Adnès, C., Emsellem, K., Ganga, O., Moebius, F., Tortorollo, N., Fox, E.A.

“…Forest fire frequency in Mediterranean countries is expected to increase with land cover and climate changes as temperatures rise and rainfall patterns are…”
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Discovery of High-Affinity Ligands of σ1 Receptor, ERG2, and Emopamil Binding Protein by Pharmacophore Modeling and Virtual Screening by Laggner, Christian, Schieferer, Claudia, Fiechtner, Birgit, Poles, Gloria, Hoffmann, Rémy D, Glossmann, Hartmut, Langer, Thierry, Moebius, Fabian F

“…ERG2, emopamil binding protein (EBP), and sigma-1 receptor (σ1) are enzymes of sterol metabolism and an enzyme-related protein, respectively, that share high…”
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Mutations in the Δ 7-sterol Reductase Gene in Patients with the Smith--Lemli--Opitz Syndrome by Fitzky, Barbara U., Witsch-Baumgartner, Martina, Erdel, Martin, Lee, Joon No, Paik, Young-Ki, Glossmann, Hartmut, Utermann, Gerd, Moebius, Fabian F.

“…The Smith--Lemli--Opitz syndrome (SLOS) is an inborn disorder of sterol metabolism with characteristic congenital malformations and dysmorphias. All patients…”
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7-Dehydrocholesterol-dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome by Fitzky, B U, Moebius, F F, Asaoka, H, Waage-Baudet, H, Xu, L, Xu, G, Maeda, N, Kluckman, K, Hiller, S, Yu, H, Batta, A K, Shefer, S, Chen, T, Salen, G, Sulik, K, Simoni, R D, Ness, G C, Glossmann, H, Patel, S B, Tint, G S

“…Smith-Lemli-Opitz/RSH syndrome (SLOS), a relatively common birth-defect mental-retardation syndrome, is caused by mutations in DHCR7, whose product catalyzes…”
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Molecular Cloning and Expression of the Human Δ 7-sterol Reductase by Moebius, Fabian F., Fitzky, Barbara U., Lee, Joon No, Paik, Young-Ki, Glossmann, Hartmut

“…Inhibitors of the last steps of cholesterol biosynthesis such as AY9944 and BM15766 severely impair brain development. Their molecular target is the Δ 7-sterol…”
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The mysteries of sigma receptors: new family members reveal a role in cholesterol synthesis by Moebius, Fabian F., Striessnig, Jörg, Glossmann, Hartmut

“…Earlier studies suggested a number of roles for sigma receptors. They were thought to represent P450 isoenzymes, or part of the IP sub(3)…”
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Mutational Spectrum in the Δ7-Sterol Reductase Gene and Genotype-Phenotype Correlation in 84 Patients with Smith-Lemli-Opitz Syndrome by Witsch-Baumgartner, M., Fitzky, B.U., Ogorelkova, M., Kraft, H.G., Moebius, F.F., Glossmann, H., Seedorf, U., Gillessen-Kaesbach, G., Hoffmann, G.F., Clayton, P., Kelley, R.I., Utermann, G.

“…Smith-Lemli-Opitz syndrome (SLOS), an autosomal recessive malformation syndrome, ranges in clinical severity from mild dysmorphism and moderate mental…”
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High affinity of sigma1‐binding sites for sterol isomerization inhibitors: evidence for a pharmacological relationship with the yeast sterol C8–C7 isomerase by Moebius, Fabian F, Reiter, Raphael J, Hanner, Markus, Glossmann, Hartmut

“…The sigma‐drug binding site of guinea‐pig liver is carried by a protein which shares significant amino acid sequence similarities with the yeast sterol C8–C7…”
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Genetic Defects in Postsqualene Cholesterol Biosynthesis by Moebius, Fabian F., Fitzky, Barbara U., Glossmann, Hartmut

“…In humans and mice, four different genetic defects in the nine biosynthetic steps from lanosterol to cholesterol have been identified. They impair the activity…”
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Mutations in the Δ7-sterol reductase gene in patients with the Smith–Lemli–Opitz syndrome by Fitzky, Barbara U., Witsch-Baumgartner, Martina, Erdel, Martin, Lee, Joon No, Paik, Young-Ki, Glossmann, Hartmut, Utermann, Gerd, Moebius, Fabian F.

“…The Smith–Lemli–Opitz syndrome (SLOS) is an inborn disorder of sterol metabolism with characteristic congenital malformations and dysmorphias. All patients…”
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7-Dehydrocholesterol–dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome by Fitzky, Barbara U., Moebius, Fabian F., Asaoka, Hitoshi, Waage-Baudet, Heather, Xu, Liwen, Xu, Guorong, Maeda, Nobuyo, Kluckman, Kimberly, Hiller, Sylvia, Yu, Hongwei, Batta, Ashok K., Shefer, Sarah, Chen, Thomas, Salen, Gerald, Sulik, Kathleen, Simoni, Robert D., Ness, Gene C., Glossmann, Hartmut, Patel, Shailendra B., Tint, G.S.

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Molecular cloning and expression of the human Δ7-sterol reductase by Moebius, Fabian F., Fitzky, Barbara U., Lee, Joon No, Paik, Young-Ki, Glossmann, Hartmut

“…Inhibitors of the last steps of cholesterol biosynthesis such as AY9944 and BM15766 severely impair brain development. Their molecular target is the Δ7-sterol…”
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Yeast Sterol C8−C7 Isomerase:  Identification and Characterization of a High-Affinity Binding Site for Enzyme Inhibitors by Moebius, Fabian F, Bermoser, Katrin, Reiter, Raphael J, Hanner, Markus, Glossmann, Hartmut

“…The yeast gene ERG2 encodes a sterol C8−C7 isomerase and is essential for ergosterol synthesis and cell proliferation. Its striking homology with the so-called…”
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Identification of PK-A Phosphorylation Sites in the Carboxyl Terminus of L-Type Calcium Channel α1 Subunits by Mitterdorfer, Jörg, Froschmayr, Monika, Grabner, Manfred, Moebius, Fabian F, Glossmann, Hartmut, Striessnig, Jörg

“…Full length L-type calcium channel α1 subunits are rapidly phosphorylated by protein kinase A (PK-A) in vitro and in vivo at sites located in their long…”
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Purification and amino-terminal sequencing of the high affinity phenylalkylamine Ca2+ antagonist binding protein from guinea pig liver endoplasmic reticulum by Moebius, F F, Hanner, M, Knaus, H G, Weber, F, Striessnig, J, Glossmann, H

“…A high affinity phenylalkylamine Ca2+ antagonist binding polypeptide (Moebius, F. F., Burrows, G. G., Striessnig, J., and Glossmann, H. (1993) Mol. Pharmacol…”
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Expression of the purported sigma(1) (sigma(1)) receptor in the mammalian brain and its possible relevance in deficits induced by antagonism of the NMDA receptor complex as revealed using an antisense strategy by Kitaichi, K, Chabot, J G, Moebius, F F, Flandorfer, A, Glossmann, H, Quirion, R

“…Sigma (sigma) receptors have generated a great deal of interest on the basis of their possible role in psychosis, neuroprotection and various other behaviors…”
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Molecular genetics of the Smith-Lemli-Opitz syndrome and postsqualene sterol metabolism by Fitzky, B U, Glossmann, H, Utermann, G, Moebius, F F

“…The Smith-Lemli-Opitz syndrome is a disorder of morphogenesis resulting from an enzymatic defect in the last step of cholesterol metabolism (reduction of…”
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Biochemical characterization of a 22-kDa high affinity antiischemic drug-binding polypeptide in the endoplasmic reticulum of guinea pig liver: potential common target for antiischemic drug action by Moebius, F F, Burrows, G G, Striessnig, J, Glossmann, H

“…The phenylalkylamine emopamil prevents brain damage due to experimental cerebral ischemia. Stereoselective, high affinity, binding sites for (-)-[3H]emopamil…”
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Expression of the purported sigma1 (σ1) receptor in the mammalian brain and its possible relevance in deficits induced by antagonism of the NMDA receptor complex as revealed using an antisense strategy by Kitaichi, Kiyoyuki, Chabot, Jean-Guy, Moebius, Fabian F., Flandorfer, Astrid, Glossmann, Hartmut, Quirion, Rémi

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