Search Results - "Modi, N B"

Ascorbate prevents placental oxidative stress and enhances birth weight in hypoxic pregnancy in rats by Richter, H. G., Camm, E. J., Modi, B. N., Naeem, F., Cross, C. M., Cindrova‐Davies, T., Spasic‐Boskovic, O., Dunster, C., Mudway, I. S., Kelly, F. J., Burton, G. J., Poston, L., Giussani, D. A.

“…Key points  •  High‐altitude pregnancy is associated with reduced oxygenation and placental complications, which can affect maternal and fetal outcome…”
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Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors by DRESSER, M. J, DESAI, D, GIDWANI, S, SEFTEL, A. D, MODI, N. B

“…Potential pharmacokinetic interactions between dapoxetine, a serotonin transporter inhibitor developed for the treatment of premature ejaculation (PE), and the…”
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Single- and Multiple-Dose Pharmacokinetics of an Oral Once-a-Day Osmotic Controlled-Release OROS® (methylphenidate HC1) Formulation by Modi, Nishit B., Lindemulder, Betsy, Gupta, Suneel K.

“…Methylphenidate is used for the treatment of attention deficit hyperactivity disorder (ADHD). OROS® (methylphenidate HCl) is an osmotic controlled‐release…”
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TNK-tissue plasminogen activator in acute myocardial infarction : Results of the thrombolysis in myocardial infarction (TIMI) 10A dose-ranging trial by CANNON, C. P, MCCABE, C. H, LOVE, T. W, BRAUNWALD, E, GIBSON, C. M, GHALI, M, SEQUEIRA, R. F, MCKENDALL, G. R, BREED, J, MODI, N. B, FOX, N. L, TRACY, R. P

“…TNK-tissue plasminogen activator (TNK-TPA) is a genetically engineered variant of TPA, which in experimental models has a slower plasma clearance and greater…”
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Orally Active Fibrinogen Receptor Antagonists. 2. Amidoximes as Prodrugs of Amidines by Weller, Thomas, Alig, Leo, Beresini, Maureen, Blackburn, Brent, Bunting, Stuart, Hadváry, Paul, Hürzeler Müller, Marianne, Knopp, Dietmar, Levet-Trafit, Bernard, Lipari, M. Terry, Modi, Nishit B, Müller, Marcel, Refino, Canio J, Schmitt, Monique, Schönholzer, Peter, Weiss, Sabine, Steiner, Beat

“…The potent and selective GP IIb-IIIa antagonist lamifiban (1, Ro 44-9883) is currently in clinical development as an injectable antithrombotic agent for…”
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Pharmacokinetics of a slower clearing tissue plasminogen activator variant, TNK-tPA, in patients with acute myocardial infarction by Modi, N B, Eppler, S, Breed, J, Cannon, C P, Braunwald, E, Love, T W

“…The rapid clearance of t-PA from plasma requires administration by intravenous (I.V.) infusion. A slower clearing, fibrin-specific rt-PA variant may allow…”
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Metabolism of [3H]pentosan polysulfate sodium (PPS) in healthy human volunteers by Simon, M., McClanahan, R. H., Shah, J. F., Repko, T., Modi, N. B.

“…Pentosan polysulfate sodium (PPS) is the active ingredient in ELMIRON®, a drug approved for the relief of bladder pain associated with interstitial cystitis…”
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Dose-Proportional and Stereospecific Pharmacokinetics of Methylphenidate Delivered Using an Osmotic, Controlled-Release Oral Delivery System by Modi, Nishit B., Wang, Bei, Noveck, Robert J., Gupta, Suneel K.

“…Methylphenidate hydrochloride (HCl) is frequently used for the treatment of attention deficit/hyperactivity disorder (ADHD). A study was conducted in healthy…”
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Application of neural networks to pharmacodynamics by Veng-Pedersen, P, Modi, N B

“…Neural networks (NN) are computational systems implemented in software or hardware that attempt to simulate the neurological processing abilities of biological…”
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A qualitative and quantitative assessment of the impact of three processing algorithms with halving of study count statistics in myocardial perfusion imaging: filtered backprojection, maximal likelihood expectation maximisation and ordered subset expectation maximisation with resolution recovery by Modi, B.N., Brown, J.L.E., Kumar, G., Driver, R.M., Kelion, A.D., Peters, A.M., Fowler, J.C.

“…Ordered subset expectation maximisation with depth-dependent resolution recovery (OSEM-RR) is a processing algorithm reported to improve images with halved…”
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Pharmacokinetics and Pharmacodynamics of Tenecteplase: Results from a Phase II Study in Patients with Acute Myocardial Infarction by Modi, Nishit B., Fox, Norma Lynn, Clow, Fong-Wong, Tanswell, Paul, Cannon, Christopher P, Van de Werf, Frans, Braunwald, Eugene

“…Tenecteplase is a site‐specific engineered tissue plasminogen activator (t‐PA) variant that can be administered as a single intravenous bolus injection because…”
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The impact of age on clinical outcomes following cardiac resynchronisation therapy by Guha, K., Konstantinou, D., Mantziari, L., Modi, B. N., Chandrasekaran, B., Khalique, Z., McDonagh, T., Sharma, R.

“…Background Cardiac resynchronisation therapy (CRT) is an established treatment for selected patients with symptomatic left ventricular (LV) systolic…”
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Effect of Dapoxetine on the Pharmacokinetics and Hemodynamic Effects of Tamsulosin in Men on a Stable Dose of Tamsulosin by Modi, N. B., Kell, S., Aquilina, J., Rivas, D.

“…The tolerability of dapoxetine, a short‐acting selective serotonin reuptake inhibitor being developed for premature ejaculation, was evaluated when…”
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Pharmacokinetics and Pharmacodynamics of Sibrafiban, an Orally Administered IIb/IIIa Antagonist, in Patients with Acute Coronary Syndrome by Modi, Nishit B., Novotny, William, Reimann, James D., Cannon, Christopher P., Braunwauld, Eugene

“…Sibrafiban is a double prodrug that is converted to the inactive single prodrug and to the active IIb/IIIa antagonist following oral administration…”
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Punch biopsy: A useful adjunct in a rapid diagnosis breast clinic by Modi, B.N, Machin, J.T, Ravichandran, D

“…Abstract Introduction Triple assessment of breast lesions usually involves the use of core biopsy (CB) or fine needle aspiration cytology (FNAC). Punch Biopsy…”
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Developmental differences in erythropoietin pharmacokinetics: increased clearance and distribution in fetal and neonatal sheep by Widness, J A, Veng-Pedersen, P, Modi, N B, Schmidt, R L, Chestnut, D H

“…Although erythropoietin (Ep) is considered the primary hormone responsible for erythrocyte production throughout development, the administration of recombinant…”
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The pharmacokinetics, tissue localization, and metabolic processing of recombinant human hepatocyte growth factor after intravenous administration in rats by Zioncheck, T F, Richardson, L, DeGuzman, G G, Modi, N B, Hansen, S E, Godowski, P J

“…Hepatocyte growth factor (HGF) is a pluripotent mitogen thought to be involved in liver regeneration. It is synthesized as a single chain promitogen and…”
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Pharmacokinetics and Pharmacodynamics of Sibrafiban, an Orally Administered GP IIb/IIIa Antagonist, following Coadministration of Aspirin and Heparin by Reimann, James D., Modi, Nishit B., Novotny, William

“…Sibrafiban is a double prodrug that is converted to the inactive single prodrug and to the active GP IIb/IIIa antagonist after oral administration. This…”
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Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor by Lin, Y S, Nguyen, C, Mendoza, J L, Escandon, E, Fei, D, Meng, Y G, Modi, N B

“…Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis and in pathological processes such as tumor growth, rheumatoid arthritis, and…”
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Pharmacokinetics, pharmacodynamics and tolerability of a potent, non-peptidic, GP IIb/IIIa receptor antagonist following multiple oral administrations of a prodrug form by Refino, C J, Modi, N B, Bullens, S, Pater, C, Lipari, M T, Robarge, K, Blackburn, B, Beresini, M, Weller, T, Steiner, B, Bunting, S

“…Ro 44-3888 is a potent and selective antagonist of GP IIb/IIIa. Following I.V. administration to rhesus monkeys, the (mean +/- SD.) clearance, volume of…”
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