Search Results - "Modi, Dimple"

Reduced PAX2 expression in murine fallopian tube cells enhances estrogen receptor signaling by Colina, Jose, Varughese, Peter, Karthikeyan, Subbulakshmi, Salvi, Amrita, Modi, Dimple, Burdette, Joanna E

“…High grade serous ovarian cancer (HGSOC) is thought to progress from a series of precursor lesions in the fallopian tube epithelium (FTE). One of the…”
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A phase 1 study of the pan‐bromodomain and extraterminal inhibitor mivebresib (ABBV‐075) alone or in combination with venetoclax in patients with relapsed/refractory acute myeloid leukemia by Borthakur, Gautam, Odenike, Olatoyosi, Aldoss, Ibrahim, Rizzieri, David A., Prebet, Thomas, Chen, Chris, Popovic, Relja, Modi, Dimple A., Joshi, Rujuta H., Wolff, Johannes E., Jonas, Brian A.

“…Background Acute myeloid leukemia (AML) is a heterogenous malignancy driven by genetic and epigenetic factors. Inhibition of bromodomain and extraterminal…”
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PTEN loss in the fallopian tube induces hyperplasia and ovarian tumor formation by Russo, Angela, Czarnecki, Austin A., Dean, Matthew, Modi, Dimple A., Lantvit, Daniel D., Hardy, Laura, Baligod, Seth, Davis, David A., Wei, Jian-Jun, Burdette, Joanna E.

“…The signaling events involved in the onset of ovarian cancer from the fallopian tube epithelium (FTE) are crucial for early detection and treatment of the…”
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Activity of eftozanermin alfa plus venetoclax in preclinical models and patients with acute myeloid leukemia by Tahir, Stephen K., Calvo, Emiliano, Carneiro, Benedito A., Yuda, Junichiro, Shreenivas, Aditya, Jongen-Lavrencic, Mojca, Gort, Eelke, Ishizawa, Kenichi, Morillo, Daniel, Biesdorf, Carla, Smith, Morey, Cheng, Dong, Motwani, Monica, Sharon, David, Uziel, Tamar, Modi, Dimple A., Buchanan, Fritz G., Morgan-Lappe, Susan, Medeiros, Bruno C., Phillips, Darren C.

“…•The antitumorigenic activity of eftoza is enhanced in combination with venetoclax in preclinical models of AML.•Eftoza-venetoclax combination is well…”
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Targeting of follicle stimulating hormone peptide-conjugated dendrimers to ovarian cancer cells by Modi, Dimple A, Sunoqrot, Suhair, Bugno, Jason, Lantvit, Daniel D, Hong, Seungpyo, Burdette, Joanna E

“…Ovarian cancer is the most lethal gynecological malignancy. Current treatment modalities include a combination of surgery and chemotherapy, which often lead to…”
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Understanding the Role of Sodium Lauryl Sulfate on the Biorelevant Solubility of a Combination of Poorly Water-Soluble Drugs Using High Throughput Experimentation and Mechanistic Absorption Modeling by Bahr, Matthew Nathan, Modi, Dimple, Patel, Sarsvatkumar, Campbell, Gossett, Stockdale, Gregory

“…This study investigates the influence of surfactant sodium lauryl sulfate (SLS) on the solubility of poorly-water soluble drug substances, model Compound X and…”
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Mutant p53 expression in fallopian tube epithelium drives cell migration by Quartuccio, Suzanne M., Karthikeyan, Subbulakshmi, Eddie, Sharon L., Lantvit, Daniel D., Ó hAinmhire, Eoghainín, Modi, Dimple A., Wei, Jian‐Jun, Burdette, Joanna E.

“…Ovarian cancer is the fifth leading cause of cancer death among US women. Evidence supports the hypothesis that high‐grade serous ovarian cancers (HGSC) may…”
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Gonadotropins activate oncogenic pathways to enhance proliferation in normal mouse ovarian surface epithelium by Hilliard, Tyvette S, Modi, Dimple A, Burdette, Joanna E

“…Ovarian cancer is the most lethal gynecological malignancy affecting American women. The gonadotropins, follicle stimulating hormone (FSH) and luteinizing…”
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Co-clinical Modeling of the Activity of the BET Inhibitor Mivebresib (ABBV-075) in AML by ALBERT, DANIEL H., GOODWIN, NEAL C., DAVIES, ANGELA M., ROWE, JENNY, FEUER, GEROLD, BOYIADZIS, MICHAEL, DORRITIE, KATHLEEN A., MANCINI, MARIA, GANDOUR-EDWARDS, REGINA, JONAS, BRIAN A., BORTHAKUR, GAUTAM, ALDOSS, IBRAHIM, RIZZIERI, DAVID A., ODENIKE, OLATOYOSI, PREBET, THOMAS, SINGH, SANJANA, POPOVIC, RELJA, SHEN, YU, MCDANIEL, KEITH F., KATI, WARREN M., MODI, DIMPLE A., MOTWANI, MONICA, WOLFF, JOHANNES E., FROST, DAVID J.

“…BACKGROUND/AIMThe therapeutic potential of bromodomain and extra-terminal motif (BET) inhibitors in hematological cancers has been well established in…”
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Non-leaking Cystoid Maculopathy Secondary to Systemic Paclitaxel by Modi, Dimple, Dubovy, Sander R

“…Taxane-associated maculopathy is scarcely reported in the literature but should be considered as a known complication of intravenous use of the chemotherapy…”
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Response to aflibercept after frequent re-treatment with bevacizumab or ranibizumab in eyes with neovascular AMD by Thorell, Mariana R, Nunes, Renata Portella, Chen, Gene W, Doshi, Rishi R, Dugar, Jyoti, George, Mathew K, Kim, Brian T, Lowrance, Matthew D, Modi, Dimple, Nahas, Zayna, Gregori, Giovanni, Yehoshua, Zohar, Feuer, William, Rosenfeld, Philip J

“…To evaluate the effects of switching to aflibercept in eyes with neovascular age-related macular degeneration (AMD) requiring frequent re-treatment with…”
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Insulin and insulin-like growth factor signaling increases proliferation and hyperplasia of the ovarian surface epithelium and decreases follicular integrity through upregulation of the PI3-kinase pathway by King, Shelby M, Modi, Dimple A, Eddie, Sharon L, Burdette, Joanna E

“…The ovarian surface epithelium responds to cytokines and hormonal cues to initiate proliferation and migration following ovulation. Although insulin and IGF…”
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Efficacy of patterned scan laser in treatment of macular edema and retinal neovascularization by Modi, Dimple, Chiranand, Paulpoj, Akduman, Levent

“…To analyze the benefits, efficacy, and complications of the PASCAL((R)) photocoagulation laser system (OptiMedica, Santa Clara, CA, USA) in patients treated at…”
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Long acting injectables for the treatment of prostate cancer by Modi, Dimple, Hussain, Md Sadique, Ainampudi, Swetha, Prajapati, Bhupendra G.

“…Prostate cancer ranks as one of the most diagnosed and challenging malignancies affecting individuals worldwide. For hormone-dependent prostate cancer…”
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Accelerate development of topical cream drug product using a common platform base formulation by Modi, Dimple, Sharma, Himanshu, Campbell, Gossett

“…The aim of this work was to identify stable topical platform cream formulations (placebo creams without active drug substance) using the quality attributes of…”
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First-in-Human Study of Mivebresib (ABBV-075), an Oral Pan-Inhibitor of Bromodomain and Extra Terminal Proteins, in Patients with Relapsed/Refractory Solid Tumors by Piha-Paul, Sarina A, Sachdev, Jasgit C, Barve, Minal, LoRusso, Patricia, Szmulewitz, Russell, Patel, Sapna Pradyuman, Lara, Jr, Primo N, Chen, Xiaotian, Hu, Beibei, Freise, Kevin J, Modi, Dimple, Sood, Anjla, Hutti, Jessica E, Wolff, Johannes, O'Neil, Bert H

“…Bromodomain and extraterminal (BET) proteins play important roles in transcriptional regulation relevant to cancer pathogenesis, and therapeutic…”
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Two Phase 1b Studies Evaluating the Safety and Tolerability of BET Inhibitors, ABBV-744 and Mivebresib, as Monotherapies and in Combination with Ruxolitinib or Navitoclax in Patients with Myelofibrosis by Mascarenhas, John, Saab, Rabih, Brackman, Deanna, Modi, Dimple A., Abraham, Linu, Ward, James E., Verstovsek, Srdan

“…Background: Myelofibrosis (MF) is a myeloproliferative neoplasm (MPN) characterized by uncontrolled inflammation and fibrotic deposition in the extracellular…”
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Etiologies, Quantitative Hypoesthesia, and Clinical Outcomes of Neurotrophic Keratopathy by Hsu, Hugo Y, Modi, Dimple

“…OBJECTIVES:To report a series of patients with neurotrophic keratopathy and to correlate visual outcomes with the causative condition, grade of ulceration, and…”
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Pharmacodynamic effects in blood and tumor tissue of eftozanermin alfa, a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist by Motwani, Monica, Modi, Dimple, Penugonda, Sudhir, Zhang, Chun, Palma, Joann, Cunningham, Alexis, Calvo, Emiliano, de Jonge, Maja J.A., LoRusso, Patricia

“…Abstract only e15668 Background: Eftozanermin alfa (eftoza; formerly known as ABBV-621), a 2nd-generation tumor necrosis factor-related apoptosis-inducing…”
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Biomarker Modulation By Mivebresib (ABBV-075) +/- Venetoclax in Relapsed/Refractory Acute Myeloid Leukemia by Borthakur, Gautam M., Odenike, Olatoyosi, Aldoss, Ibrahim, Rizzieri, David A., Prebet, Thomas, Modi, Dimple A., Joshi, Rujuta, Hu, Beibei, Sun, Yan, Wolff, Johannes E., Jonas, Brian A

“…Background: The bromodomain and extra terminal (BET) family of proteins bind acetylated histone tails, leading to the regulation of oncogenic target genes…”
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