Search Results - "Modern pathology"

Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies by Tian, Sufang, Xiong, Yong, Liu, Huan, Niu, Li, Guo, Jianchun, Liao, Meiyan, Xiao, Shu-Yuan

“…Data on pathologic changes of the 2019 novel coronavirus disease (COVID-19) are scarce. To gain knowledge about the pathology that may contribute to disease…”
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A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression by Polak, Samuel B., Van Gool, Inge C., Cohen, Danielle, von der Thüsen, Jan H., van Paassen, Judith

“…Since the outbreak of the COVID-19 pandemic, much has been learned regarding its clinical course, prognostic inflammatory markers, disease complications, and…”
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COVID-19 pulmonary pathology: a multi-institutional autopsy cohort from Italy and New York City by Borczuk, Alain C., Salvatore, Steven P., Seshan, Surya V., Patel, Sanjay S., Bussel, James B., Mostyka, Maria, Elsoukkary, Sarah, He, Bing, Del Vecchio, Claudia, Fortarezza, Francesco, Pezzuto, Federica, Navalesi, Paolo, Crisanti, Andrea, Fowkes, Mary E., Bryce, Clare H., Calabrese, Fiorella, Beasley, Mary Beth

“…SARS-CoV-2, the etiologic agent of COVID-19, is a global pandemic with substantial mortality dominated by acute respiratory distress syndrome. We…”
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NTRK fusion detection across multiple assays and 33,997 cases: diagnostic implications and pitfalls by Solomon, James P., Linkov, Irina, Rosado, Andrea, Mullaney, Kerry, Rosen, Ezra Y., Frosina, Denise, Jungbluth, Achim A., Zehir, Ahmet, Benayed, Ryma, Drilon, Alexander, Hyman, David M., Ladanyi, Marc, Sireci, Anthony N., Hechtman, Jaclyn F.

“…With the FDA approval of larotrectinib, NTRK fusion assessment has recently become a standard part of management for patients with locally advanced or…”
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Digital pathology and artificial intelligence in translational medicine and clinical practice by Baxi, Vipul, Edwards, Robin, Montalto, Michael, Saha, Saurabh

“…Traditional pathology approaches have played an integral role in the delivery of diagnosis, semi-quantitative or qualitative assessment of protein expression,…”
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Molecular characterization of cancers with NTRK gene fusions by Gatalica, Zoran, Xiu, Joanne, Swensen, Jeffrey, Vranic, Semir

“…Targeted inhibitors of neurotropic tyrosine kinases are highly effective in selected patients with gene fusions involving NTRK1, NTRK2 , or NTRK3 . These…”
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In situ detection of SARS-CoV-2 in lungs and airways of patients with COVID-19 by Schaefer, Inga-Marie, Padera, Robert F., Solomon, Isaac H., Kanjilal, Sanjat, Hammer, Mark M., Hornick, Jason L., Sholl, Lynette M.

“…Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has led to a global public health crisis. In elderly individuals and those with comorbidities,…”
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Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experience by Bryce, Clare, Grimes, Zachary, Pujadas, Elisabet, Ahuja, Sadhna, Beasley, Mary Beth, Albrecht, Randy, Hernandez, Tahyna, Stock, Aryeh, Zhao, Zhen, AlRasheed, Mohamed Rizwan, Chen, Joyce, Li, Li, Wang, Diane, Corben, Adriana, Haines, G. Kenneth, Westra, William H., Umphlett, Melissa, Gordon, Ronald E., Reidy, Jason, Petersen, Bruce, Salem, Fadi, Fiel, Maria Isabel, El Jamal, Siraj M., Tsankova, Nadejda M., Houldsworth, Jane, Mussa, Zarmeen, Veremis, Brandon, Sordillo, Emilia, Gitman, Melissa R., Nowak, Michael, Brody, Rachel, Harpaz, Noam, Merad, Miriam, Gnjatic, Sacha, Liu, Wen-Chun, Schotsaert, Michael, Miorin, Lisa, Aydillo Gomez, Teresa A., Ramos-Lopez, Irene, Garcia-Sastre, Adolfo, Donnelly, Ryan, Seigler, Patricia, Keys, Calvin, Cameron, Jennifer, Moultrie, Isaiah, Washington, Kae-Lynn, Treatman, Jacquelyn, Sebra, Robert, Jhang, Jeffrey, Firpo, Adolfo, Lednicky, John, Paniz-Mondolfi, Alberto, Cordon-Cardo, Carlos, Fowkes, Mary E.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated clinical syndrome COVID-19 are causing overwhelming morbidity and mortality…”
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SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers by Hecht, Jonathon L., Quade, Bradley, Deshpande, Vikram, Mino-Kenudson, Mari, Ting, David T., Desai, Niyati, Dygulska, Beata, Heyman, Taryn, Salafia, Carolyn, Shen, Dejun, Bates, Sara V., Roberts, Drucilla J.

“…Congenital infection of SARS-CoV-2 appears to be exceptionally rare despite many cases of COVID-19 during pregnancy. Robust proof of placental infection…”
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Hepatic pathology in patients dying of COVID-19: a series of 40 cases including clinical, histologic, and virologic data by Lagana, Stephen M., Kudose, Satoru, Iuga, Alina C., Lee, Michael J., Fazlollahi, Ladan, Remotti, Helen E., Del Portillo, Armando, De Michele, Simona, de Gonzalez, Anne Koehne, Saqi, Anjali, Khairallah, Pascale, Chong, Alexander M., Park, Heekuk, Uhlemann, Anne-Catrin, Lefkowitch, Jay H., Verna, Elizabeth C.

“…The novel coronavirus SARS-CoV-2 (coronavirus disease 19, or COVID-19) primarily causes pulmonary injury, but has been implicated to cause hepatic injury, both…”
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New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia by Trpkov, Kiril, Hes, Ondrej, Williamson, Sean R., Adeniran, Adebowale J., Agaimy, Abbas, Alaghehbandan, Reza, Amin, Mahul B., Argani, Pedram, Chen, Ying-Bei, Cheng, Liang, Epstein, Jonathan I., Cheville, John C., Comperat, Eva, da Cunha, Isabela Werneck, Gordetsky, Jennifer B., Gupta, Sounak, He, Huiying, Hirsch, Michelle S., Humphrey, Peter A., Kapur, Payal, Kojima, Fumiyoshi, Lopez, Jose I., Maclean, Fiona, Magi-Galluzzi, Cristina, McKenney, Jesse K., Mehra, Rohit, Menon, Santosh, Netto, George J., Przybycin, Christopher G., Rao, Priya, Rao, Qiu, Reuter, Victor E., Saleeb, Rola M., Shah, Rajal B., Smith, Steven C., Tickoo, Satish, Tretiakova, Maria S., True, Lawrence, Verkarre, Virginie, Wobker, Sara E., Zhou, Ming, Gill, Anthony J.

“…The Genitourinary Pathology Society (GUPS) reviewed recent advances in renal neoplasia, particularly post-2016 World Health Organization (WHO) classification,…”
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Molecular testing for BRAF mutations to inform melanoma treatment decisions: a move toward precision medicine by Cheng, Liang, Lopez-Beltran, Antonio, Massari, Francesco, MacLennan, Gregory T, Montironi, Rodolfo

“…Approximately one-half of advanced (unresectable or metastatic) melanomas harbor a mutation in the BRAF gene, with V600E being the most common mutation…”
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Implications of the tumor immune microenvironment for staging and therapeutics by Taube, Janis M, Galon, Jérôme, Sholl, Lynette M, Rodig, Scott J, Cottrell, Tricia R, Giraldo, Nicolas A, Baras, Alexander S, Patel, Sanjay S, Anders, Robert A, Rimm, David L, Cimino-Mathews, Ashley

“…Characterizing the tumor immune microenvironment enables the identification of new prognostic and predictive biomarkers, the development of novel therapeutic…”
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Hepatotoxicity of immune checkpoint inhibitors: a histology study of seven cases in comparison with autoimmune hepatitis and idiosyncratic drug-induced liver injury by Zen, Yoh, Yeh, Matthew M.

“…The adverse effects of immune checkpoint inhibitors in various organs may be attributed to immune-mediated processes triggered by disrupted self-tolerance;…”
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Risk assessment in solitary fibrous tumors: validation and refinement of a risk stratification model by Demicco, Elizabeth G, Wagner, Michael J, Maki, Robert G, Gupta, Vishal, Iofin, Ilya, Lazar, Alexander J, Wang, Wei-Lien

“…Solitary fibrous tumors are an uncommon sarcoma type characterized by NAB2–STAT6 gene fusion. While solitary fibrous tumors metastasize in 5–25% of cases, it…”
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Development of a prognostic model for mortality in COVID-19 infection using machine learning by Booth, Adam L., Abels, Elizabeth, McCaffrey, Peter

“…Coronavirus disease 2019 (COVID-19) is a novel disease resulting from infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has…”
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Harmonized PD-L1 immunohistochemistry for pulmonary squamous-cell and adenocarcinomas by Scheel, Andreas H, Dietel, Manfred, Heukamp, Lukas C, Jöhrens, Korinna, Kirchner, Thomas, Reu, Simone, Rüschoff, Josef, Schildhaus, Hans-Ulrich, Schirmacher, Peter, Tiemann, Markus, Warth, Arne, Weichert, Wilko, Fischer, Rieke N, Wolf, Jürgen, Buettner, Reinhard

“…Immunohistochemistry of the PD-L1 protein may be predictive for anti-PD-1 and anti-PD-L1 immunotherapy in pulmonary adenocarcinoma and in clinically unselected…”
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“Interchangeability” of PD-L1 immunohistochemistry assays: a meta-analysis of diagnostic accuracy by Torlakovic, Emina, Lim, Hyun J., Adam, Julien, Barnes, Penny, Bigras, Gilbert, Chan, Anthony W. H., Cheung, Carol C., Chung, Jin-Haeng, Couture, Christian, Fiset, Pierre O., Fujimoto, Daichi, Han, Gang, Hirsch, Fred R., Ilie, Marius, Ionescu, Diana, Li, Chao, Munari, Enrico, Okuda, Katsuhiro, Ratcliffe, Marianne J., Rimm, David L., Ross, Catherine, Røge, Rasmus, Scheel, Andreas H., Soo, Ross A., Swanson, Paul E., Tretiakova, Maria, To, Ka F., Vainer, Gilad W., Wang, Hangjun, Xu, Zhaolin, Zielinski, Dirk, Tsao, Ming-Sound

“…Different clones, protocol conditions, instruments, and scoring/readout methods may pose challenges in introducing different PD-L1 assays for immunotherapy…”
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TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer by Ai, Di, Yao, Jun, Yang, Fei, Huo, Lei, Chen, Hui, Lu, Wei, Soto, Luisa Maren Solis, Jiang, Mei, Raso, Maria Gabriela, Wang, Shufang, Bell, Diana, Liu, Jinsong, Wang, Huamin, Tan, Dongfeng, Torres-Cabala, Carlos, Gan, Qiong, Wu, Yun, Albarracin, Constance, Hung, Mien-Chie, Meric-Bernstam, Funda, Wistuba, Ignacio I., Prieto, Victor G., Sahin, Aysegul A., Ding, Qingqing

“…Currently there is no highly specific and sensitive marker to identify breast cancer—the most common malignancy in women. Breast cancer can be categorized as…”
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Lung neuroendocrine neoplasms: recent progress and persistent challenges by Rekhtman, Natasha

“…This review summarizes key recent developments relevant to the pathologic diagnosis of lung neuroendocrine neoplasms, including carcinoids, small cell lung…”
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