Search Results - "Modarai, Shirin"

APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development by Zhang, Tao, Ahn, Koree, Emerick, Brooks, Modarai, Shirin R, Opdenaker, Lynn M, Palazzo, Juan, Schleiniger, Gilberto, Fields, Jeremy Z, Boman, Bruce M

“…APC mutations drive human colorectal cancer (CRC) development. A major contributing factor is colonic stem cell (SC) overpopulation. But, the mechanism has not…”
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Precise and error-prone CRISPR-directed gene editing activity in human CD34+ cells varies widely among patient samples by Modarai, Shirin R., Kanda, Sambee, Bloh, Kevin, Opdenaker, Lynn M., Kmiec, Eric B.

“…Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and their associated CRISPR-associated nucleases (Cas) are among the most promising…”
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The anti-cancer effect of retinoic acid signaling in CRC occurs via decreased growth of ALDH+ colon cancer stem cells and increased differentiation of stem cells by Modarai, Shirin R, Gupta, Anindita, Opdenaker, Lynn M, Kowash, Ryan, Masters, Gabriel, Viswanathan, Vignesh, Zhang, Tao, Fields, Jeremy Z, Boman, Bruce M

“…Tumorigenesis is driven by stem cell (SC) overpopulation. Because ALDH is both a marker for SCs in many tissues and a key enzyme in retinoid acid (RA)…”
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Somatostatin signaling via SSTR1 contributes to the quiescence of colon cancer stem cells by Modarai, Shirin R, Opdenaker, Lynn M, Viswanathan, Vignesh, Fields, Jeremy Z, Boman, Bruce M

“…Neuroendocrine cells (NECs) reside adjacent to colonic stem cells (SCs) in the crypt stem cell (SC) niche, but how NECs are involved in regulation of SCs is…”
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MicroRNA Expression Profiling of Normal and Malignant Human Colonic Stem Cells Identifies miRNA92a as a Regulator of the LRIG1 Stem Cell Gene by Viswanathan, Vignesh, Opdenaker, Lynn, Modarai, Shirin, Fields, Jeremy Z, Gonye, Gregory, Boman, Bruce M

“…MicroRNAs (miRNAs) have a critical role in regulating stem cells (SCs) during development, and because aberrant expression of miRNAs occurs in various cancers,…”
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An miRNA Expression Signature for the Human Colonic Stem Cell Niche Distinguishes Malignant from Normal Epithelia by Viswanathan, Vignesh, Damle, Shirish, Zhang, Tao, Opdenaker, Lynn, Modarai, Shirin, Accerbi, Monica, Schmidt, Skye, Green, Pamela, Galileo, Deni, Palazzo, Juan, Fields, Jeremy, Haghighat, Sepehr, Rigoutsos, Isidore, Gonye, Greg, Boman, Bruce M

“…Malignant transformation of tissue stem cells (SC) may be the root of most cancer. Accordingly, we identified miRNA expression patterns in the normal human…”
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Efficient Delivery and Nuclear Uptake Is Not Sufficient to Detect Gene Editing in CD34+ Cells Directed by a Ribonucleoprotein Complex by Modarai, Shirin R., Man, Dula, Bialk, Pawel, Rivera-Torres, Natalia, Bloh, Kevin, Kmiec, Eric B.

“…CD34+ cells are prime targets for therapeutic strategies for gene editing, because modified progenitor cells have the capacity to differentiate through an…”
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Exon skipping induced by CRISPR-directed gene editing regulates the response to chemotherapy in non-small cell lung carcinoma cells by Banas, Kelly, Modarai, Shirin, Rivera-Torres, Natalia, Yoo, Byung-Chun, Bialk, Pawel A., Barrett, Connor, Batish, Mona, Kmiec, Eric B.

“…We have been developing CRISPR-directed gene editing as an augmentative therapy for the treatment of non-small cell lung carcinoma (NSCLC) by genetic…”
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Abstract 1136: Decrease in maturation of stem cells along the neuroendocrine lineage contributes to stem cell overpopulation that drives human CRC development by Boman, Bruce M., Zhang, Tao, Modarai, Shirin, Opdenacker, Lynn, Jeremy, Fields

“…Stem cell (SC) overpopulation is thought to drive tumor initiation and progression during colon cancer development, but it is unclear what causes the SC…”
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Abstract LB-147: Colonic crypt neuroendocrine cells regulate colonic stem cells during colorectal cancer development by Modarai, Shirin R., Opdenaker, Lynn M., Boman, Bruce M.

“…Our studies on tissues from colon cancer patients show that in the development of CRC, stem cells (SC) overpopulation underlies tumor initiation and…”
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Abstract 2878: Anti-cancer effects of retinoic acid in CRC occurs via decreased growth of ALDH+ cancer stem cells and increased differentiation of stem cells to neuroendocrine cells by Modarai, Shirin R., Opdenaker, Lynn M., Gupta, Anindita, Fields, Jeremy Z., Boman, Bruce M.

“…Our studies on tissues from colon cancer patients show that in the development of colorectal cancer (CRC), stem cell (SC) overpopulation underlies tumor…”
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GERG Study 2019: Reproducibility of indel formation rates by comparing guideRNA format and delivery method by Sergison, Elizabeth, Delventhal, Kym, Pruett-Miller, Shondra, Modarai, Shirin, Kmiec, Eric, Regan, Maureen, Miller, Brandon

“…Recent advances in genome engineering are allowing scientists to better understand biology by precisely deleting, editing, or tagging genomic DNA. The…”
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Abstract 5019: Stem cell and neuroendocrine cell phenotypes of normal and malignant colonic cells by Modarai, Shirin R., Opdenaker, Lynn M., Boman, Bruce M.

“…In the development of colorectal cancer (CRC), stem cell (SC) overpopulation underlies tumor initiation and progression, but the underlying mechanisms are…”
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Reproducibility of Indel Formation Rates by Comparing GuideRNA Format and Delivery Method by Delventhal, Kym, Miller, Brandon, Pruett-Miller, Shondra M, Modarai, Shirin, Porter, Shaina N, Regan, Maureen R, Sergison, Elizabeth

“…Multiple configurations of guideRNA and Cas9 components can be used for editing cells. A few options include: a plasmid expressing both the guideRNA and Cas9,…”
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Abstract 4256: Neuroendocrine, stem, and stromal cell interactions involved in the organization of the normal colonic stem cell niche which become disorganized during colon tumorigenesis by Modarai, Shirin, Kurtoglu, Senem, Opdenaker, Lynn, Zhang, Tao, Ahn, Koree, Boman, Bruce M.

“…In development of colorectal cancer (CRC), stem cell (SC) overpopulation underlies tumor initiation and progression, but it is incompletely understood which…”
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Stem cell and neuroendocrine cell phenotypes in normal and malignant colonic cells by Modarai, Shirin Raya

“…In the development of colorectal cancer (CRC), stem cell (SC) overpopulation underlies tumor initiation and progression, but the underlying mechanisms are…”
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Stem cell and neuroendocrine cell phenotypes in normal and malignant colonic cells by Modarai, Shirin Raya

“…In the development of colorectal cancer (CRC), stem cell (SC) overpopulation underlies tumor initiation and progression, but the underlying mechanisms are…”
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