Search Results - "Modahl, Cassandra M."

Cysteine-Rich Secretory Proteins (CRISPs) From Venomous Snakes: An Overview of the Functional Diversity in A Large and Underappreciated Superfamily by Tadokoro, Takashi, Modahl, Cassandra M, Maenaka, Katsumi, Aoki-Shioi, Narumi

“…The CAP protein superfamily (Cysteine-rich secretory proteins (CRISPs), Antigen 5 (Ag5), and Pathogenesis-related 1 (PR-1) proteins) is widely distributed, but…”
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Adaptive evolution of distinct prey-specific toxin genes in rear-fanged snake venom by Modahl, Cassandra M, Mrinalini, Frietze, Seth, Mackessy, Stephen P

“…Venom proteins evolve rapidly, and as a trophic adaptation are excellent models for predator-prey evolutionary studies. The key to a deeper understanding of…”
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Niemann-Pick Type C2 Proteins in Aedes aegypti : Molecular Modelling and Prediction of Their Structure-Function Relationships by Thambi, Prathigna Jaishankar, Modahl, Cassandra M, Kini, R Manjunatha

“…is a major vector that transmits arboviruses through the saliva injected into the host. Salivary proteins help in uninterrupted blood intake and enhance the…”
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JNK pathway restricts DENV2, ZIKV and CHIKV infection by activating complement and apoptosis in mosquito salivary glands by Chowdhury, Avisha, Modahl, Cassandra M, Tan, Siok Thing, Wong Wei Xiang, Benjamin, Missé, Dorothée, Vial, Thomas, Kini, R. Manjunatha, Pompon, Julien Francis, Dimopoulos, George, Cherry, Sara

“…Arbovirus infection of Aedes aegypti salivary glands (SGs) determines transmission. However, there is a dearth of knowledge on SG immunity. Here, we…”
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High resolution proteomics of Aedes aegypti salivary glands infected with either dengue, Zika or chikungunya viruses identify new virus specific and broad antiviral factors by Chowdhury, Avisha, Modahl, Cassandra M., Missé, Dorothée, Kini, R. Manjunatha, Pompon, Julien

“…Arboviruses such as dengue (DENV), Zika (ZIKV) and chikungunya (CHIKV) viruses infect close to half a billion people per year, and are primarily transmitted…”
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The RNA binding protein Quaking represses splicing of the Fibronectin EDA exon and downregulates the interferon response by Liao, Kuo-Chieh, Chuo, Vanessa, Fagg, W Samuel, Modahl, Cassandra M, Widen, Steven, Garcia-Blanco, Mariano A

“…Abstract Quaking (QKI) controls RNA metabolism in many biological processes including innate immunity, where its roles remain incompletely understood. To…”
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Editorial: Experimental and computational aspects of bioactive proteins from animal venoms: an insight into pharmacological properties and drug discovery by Yap, Michelle Khai Khun, Modahl, Cassandra M, Hall, Steven R

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Distinct regulatory networks control toxin gene expression in elapid and viperid snakes by Modahl, Cassandra M, Han, Summer Xia, van Thiel, Jory, Vaz, Candida, Dunstan, Nathan L, Frietze, Seth, Jackson, Timothy N W, Mackessy, Stephen P, Kini, R Manjunatha

“…Venom systems are ideal models to study genetic regulatory mechanisms that underpin evolutionary novelty. Snake venom glands are thought to share a common…”
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Transcriptomics-guided bottom-up and top-down venomics of neonate and adult specimens of the arboreal rear-fanged Brown Treesnake, Boiga irregularis, from Guam by Pla, Davinia, Petras, Daniel, Saviola, Anthony J., Modahl, Cassandra M., Sanz, Libia, Pérez, Alicia, Juárez, Elena, Frietze, Seth, Dorrestein, Pieter C., Mackessy, Stephen P., Calvete, Juan J.

“…The Brown Treesnake (Boiga irregularis) is an arboreal, nocturnal, rear-fanged venomous snake native to northern and eastern regions of Australia, Papua New…”
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Midgut transcriptomic responses to dengue and chikungunya viruses in the vectors Aedes albopictus and Aedes malayensis by Modahl, Cassandra M., Chowdhury, Avisha, Low, Dolyce H. W., Manuel, Menchie C., Missé, Dorothée, Kini, R. Manjunatha, Mendenhall, Ian H., Pompon, Julien

“…Dengue (DENV) and chikungunya (CHIKV) viruses are among the most preponderant arboviruses. Although primarily transmitted through the bite of Aedes aegypti…”
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Full-Length Venom Protein cDNA Sequences from Venom-Derived mRNA: Exploring Compositional Variation and Adaptive Multigene Evolution by Modahl, Cassandra M, Mackessy, Stephen P

“…Envenomation of humans by snakes is a complex and continuously evolving medical emergency, and treatment is made that much more difficult by the diverse…”
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Omics Technologies for Profiling Toxin Diversity and Evolution in Snake Venom: Impacts on the Discovery of Therapeutic and Diagnostic Agents by Modahl, Cassandra M, Brahma, Rajeev Kungur, Koh, Cho Yeow, Shioi, Narumi, Kini, R. Manjunatha

“…Snake venoms are primarily composed of proteins and peptides, and these toxins have developed high selectivity to their biological targets. This makes venoms…”
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Investigating Snake-Venom-Induced Dermonecrosis and Inflammation Using an Ex Vivo Human Skin Model by Alsolaiss, Jaffer, Leeming, Gail, Da Silva, Rachael, Alomran, Nessrin, Casewell, Nicholas R, Habib, Abdulrazaq G, Harrison, Robert A, Modahl, Cassandra M

“…Snakebite envenoming is a neglected tropical disease that causes >100,000 deaths and >400,000 cases of morbidity annually. Despite the use of mouse models,…”
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Studying Venom Toxin Variation Using Accurate Masses from Liquid Chromatography-Mass Spectrometry Coupled with Bioinformatic Tools by Alonso, Luis L, van Thiel, Jory, Slagboom, Julien, Dunstan, Nathan, Modahl, Cassandra M, Jackson, Timothy N W, Samanipour, Saer, Kool, Jeroen

“…This study provides a new methodology for the rapid analysis of numerous venom samples in an automated fashion. Here, we use LC-MS (Liquid Chromatography-Mass…”
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Highly Evolvable: Investigating Interspecific and Intraspecific Venom Variation in Taipans ( Oxyuranus spp.) and Brown Snakes ( Pseudonaja spp.) by van Thiel, Jory, Alonso, Luis L, Slagboom, Julien, Dunstan, Nathan, Wouters, Roel M, Modahl, Cassandra M, Vonk, Freek J, Jackson, Timothy N W, Kool, Jeroen

“…Snake venoms are complex mixtures of toxins that differ on interspecific (between species) and intraspecific (within species) levels. Whether venom variation…”
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Transcriptomic Signatures of Tacaribe Virus-Infected Jamaican Fruit Bats by Gerrard, Diana L, Hawkinson, Ann, Sherman, Tyler, Modahl, Cassandra M, Hume, Gretchen, Campbell, Corey L, Schountz, Tony, Frietze, Seth

“…Tacaribe virus (TCRV) is a mammalian arenavirus that was first isolated from artibeus bats in the 1950s. Subsequent experimental infection of Jamaican fruit…”
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Transcriptome-facilitated proteomic characterization of rear-fanged snake venoms reveal abundant metalloproteinases with enhanced activity by Modahl, Cassandra M., Frietze, Seth, Mackessy, Stephen P.

“…High-throughput technologies were used to identify venom gland toxin expression and to characterize the venom proteomes of two rear-fanged snakes, Ahaetulla…”
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An analysis of venom ontogeny and prey-specific toxicity in the Monocled Cobra (Naja kaouthia) by Modahl, Cassandra M., Mukherjee, Ashis K., Mackessy, Stephen P.

“…Venoms of snakes of the family Elapidae (cobras, kraits, mambas, and relatives) are predominantly composed of numerous phospholipases A2 (PLA2s) and…”
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Interspecific and intraspecific venom enzymatic variation among cobras (Naja sp. and Ophiophagus hannah) by Modahl, Cassandra M., Roointan, Amir, Rogers, Jessica, Currier, Katelyn, Mackessy, Stephen P.

“…The genera Ophiophagus and Naja comprise part of a clade of snakes referred to as cobras, dangerously venomous front-fanged snakes in the family Elapidae…”
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Integration of transcriptomic and proteomic approaches for snake venom profiling by Modahl, Cassandra M, Saviola, Anthony J, Mackessy, Stephen P

“…Snake venoms contain many protein and peptide isoforms with high levels of sequence variation, even within a single species. In this review, we highlight…”
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