Multisite, double-blind, placebo-controlled trial of porcine secretin in autism

To examine the efficacy of intravenous porcine secretin for the treatment of autistic disorder. Randomized, double-blind, placebo-controlled, crossover design. Fifty-six subjects with autistic disorder received either a secretin or placebo infusion at baseline and the other substance at week 4. Subj...

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Bibliographic Details
Published in:Journal of the American Academy of Child and Adolescent Psychiatry Vol. 40; no. 11; p. 1293
Main Authors: Owley, T, McMahon, W, Cook, E H, Laulhere, T, South, M, Mays, L Z, Shernoff, E S, Lainhart, J, Modahl, C B, Corsello, C, Ozonoff, S, Risi, S, Lord, C, Leventhal, B L, Filipek, P A
Format: Journal Article
Language:English
Published: United States 01-11-2001
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Summary:To examine the efficacy of intravenous porcine secretin for the treatment of autistic disorder. Randomized, double-blind, placebo-controlled, crossover design. Fifty-six subjects with autistic disorder received either a secretin or placebo infusion at baseline and the other substance at week 4. Subjects were given the Autism Diagnostic Observation Schedule (ADOS) and other pertinent developmental measures at baseline and at weeks 4 and 8 to assess drug effects. For the primary efficacy analysis, change of ADOS social-communication total score from week 0 to week 4, no statistically significant difference was obtained between placebo (-0.8 +/- 2.9) and secretin groups (-0.6 +/- 1.4; t54 = 0.346, p < .73). The other measures showed no treatment effect for secretin compared with placebo. There was no evidence for efficacy of secretin in this randomized, placebo-controlled, double-blind trial.
ISSN:0890-8567
DOI:10.1097/00004583-200111000-00009