Search Results - "Moco, Sofia"

Studying Metabolism by NMR-Based Metabolomics by Moco, Sofia

“…During the past few decades, the direct analysis of metabolic intermediates in biological samples has greatly improved the understanding of metabolic…”
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Resveratrol and Its Human Metabolites-Effects on Metabolic Health and Obesity by Springer, Margherita, Moco, Sofia

“…Resveratrol is one of the most widely studied polyphenols and it has been assigned a plethora of metabolic effects with potential health benefits. Given its…”
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Ultrahigh Performance Liquid Chromatography−Tandem Mass Spectrometry Method for Fast and Robust Quantification of Anionic and Aromatic Metabolites by Buescher, Joerg Martin, Moco, Sofia, Sauer, Uwe, Zamboni, Nicola

“…Quantification of metabolites is of pivotal relevance in biology, where it complements more established omics techniques such as transcriptomics and…”
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Factors affecting intake, metabolism and health benefits of phenolic acids: do we understand individual variability? by Bento-Silva, Andreia, Koistinen, Ville M., Mena, Pedro, Bronze, Maria R., Hanhineva, Kati, Sahlstrøm, Stefan, Kitrytė, Vaida, Moco, Sofia, Aura, Anna-Marja

“…Introduction Phenolic acids are important phenolic compounds widespread in foods, contributing to nutritional and organoleptic properties. Factors affceting…”
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Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells by Chareyron, Isabelle, Christen, Stefan, Moco, Sofia, Valsesia, Armand, Lassueur, Steve, Dayon, Loïc, Wollheim, Claes B., Santo Domingo, Jaime, Wiederkehr, Andreas

“…Aims/hypothesis In islets from individuals with type 2 diabetes and in islets exposed to chronic elevated glucose, mitochondrial energy metabolism is impaired…”
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Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities by Migliavacca, Eugenia, Tay, Stacey K. H., Patel, Harnish P., Sonntag, Tanja, Civiletto, Gabriele, McFarlane, Craig, Forrester, Terence, Barton, Sheila J., Leow, Melvin K., Antoun, Elie, Charpagne, Aline, Seng Chong, Yap, Descombes, Patrick, Feng, Lei, Francis-Emmanuel, Patrice, Garratt, Emma S., Giner, Maria Pilar, Green, Curtis O., Karaz, Sonia, Kothandaraman, Narasimhan, Marquis, Julien, Metairon, Sylviane, Moco, Sofia, Nelson, Gail, Ngo, Sherry, Pleasants, Tony, Raymond, Frederic, Sayer, Avan A., Ming Sim, Chu, Slater-Jefferies, Jo, Syddall, Holly E., Fang Tan, Pei, Titcombe, Philip, Vaz, Candida, Westbury, Leo D., Wong, Gerard, Yonghui, Wu, Cooper, Cyrus, Sheppard, Allan, Godfrey, Keith M., Lillycrop, Karen A., Karnani, Neerja, Feige, Jerome N.

“…The causes of impaired skeletal muscle mass and strength during aging are well-studied in healthy populations. Less is known on pathological age-related muscle…”
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SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease by Gut, Philipp, Matilainen, Sanna, Meyer, Jesse G., Pällijeff, Pieti, Richard, Joy, Carroll, Christopher J., Euro, Liliya, Jackson, Christopher B., Isohanni, Pirjo, Minassian, Berge A., Alkhater, Reem A., Østergaard, Elsebet, Civiletto, Gabriele, Parisi, Alice, Thevenet, Jonathan, Rardin, Matthew J., He, Wenjuan, Nishida, Yuya, Newman, John C., Liu, Xiaojing, Christen, Stefan, Moco, Sofia, Locasale, Jason W., Schilling, Birgit, Suomalainen, Anu, Verdin, Eric

“…Mitochondrial acyl-coenzyme A species are emerging as important sources of protein modification and damage. Succinyl-CoA ligase (SCL) deficiency causes a…”
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Metabolomics View on Gut Microbiome Modulation by Polyphenol-rich Foods by Moco, Sofia, Martin, François-Pierre J, Rezzi, Serge

“…Health is influenced by genetic, lifestyle, and diet determinants; therefore, nutrition plays an essential role in health management. Still, the substantiation…”
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A computationally driven analysis of the polyphenol-protein interactome by Lacroix, Sébastien, Klicic Badoux, Jasna, Scott-Boyer, Marie-Pier, Parolo, Silvia, Matone, Alice, Priami, Corrado, Morine, Melissa J., Kaput, Jim, Moco, Sofia

“…Polyphenol-rich foods are part of many nutritional interventions aimed at improving health and preventing cardiometabolic diseases (CMDs). Polyphenols have…”
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Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival by Ros, Susana, Santos, Claudio R, Moco, Sofia, Baenke, Franziska, Kelly, Gavin, Howell, Michael, Zamboni, Nicola, Schulze, Almut

“…Alterations in metabolic activity contribute to the proliferation and survival of cancer cells. We investigated the effect of siRNA-mediated gene silencing of…”
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Contribution of genetic ancestry and polygenic risk score in meeting vitamin B12 needs in healthy Brazilian children and adolescents by Fuzo, Carlos Alessandro, da Veiga Ued, Fábio, Moco, Sofia, Cominetti, Ornella, Métairon, Sylviane, Pruvost, Solenn, Charpagne, Aline, Carayol, Jerome, Torrieri, Raul, Silva, Wilson Araujo, Descombes, Patrick, Kaput, Jim, Monteiro, Jacqueline Pontes

“…Polymorphisms in genes related to the metabolism of vitamin B12 haven’t been examined in a Brazilian population. To (a) determine the correlation between the…”
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Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage by Sambeat, Audrey, Ratajczak, Joanna, Joffraud, Magali, Sanchez-Garcia, José L., Giner, Maria P., Valsesia, Armand, Giroud-Gerbetant, Judith, Valera-Alberni, Miriam, Cercillieux, Angelique, Boutant, Marie, Kulkarni, Sameer S., Moco, Sofia, Canto, Carles

“…Supplementation with the NAD + precursor nicotinamide riboside (NR) ameliorates and prevents a broad array of metabolic and aging disorders in mice. However,…”
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A reduced form of nicotinamide riboside defines a new path for NAD+ biosynthesis and acts as an orally bioavailable NAD+ precursor by Giroud-Gerbetant, Judith, Joffraud, Magali, Giner, Maria Pilar, Cercillieux, Angelique, Bartova, Simona, Makarov, Mikhail V., Zapata-Pérez, Rubén, Sánchez-García, José L., Houtkooper, Riekelt H., Migaud, Marie E., Moco, Sofia, Canto, Carles

“…A decay in intracellular NAD+ levels is one of the hallmarks of physiological decline in normal tissue functions. Accordingly, dietary supplementation with…”
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Untargeted large-scale plant metabolomics using liquid chromatography coupled to mass spectrometry by De Vos, Ric CH, Moco, Sofia, Lommen, Arjen, Keurentjes, Joost JB, Bino, Raoul J, Hall, Robert D

“…Untargeted metabolomics aims to gather information on as many metabolites as possible in biological systems by taking into account all information present in…”
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A Method to Monitor the NAD + Metabolome-From Mechanistic to Clinical Applications by Giner, Maria Pilar, Christen, Stefan, Bartova, Simona, Makarov, Mikhail V, Migaud, Marie E, Canto, Carles, Moco, Sofia

“…Nicotinamide adenine dinucleotide (NAD ) and its reduced form (NADH) are coenzymes employed in hundreds of metabolic reactions. NAD also serves as a substrate…”
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AMPK promotes survival of c‐Myc‐positive melanoma cells by suppressing oxidative stress by Kfoury, Alain, Armaro, Marzia, Collodet, Caterina, Sordet‐Dessimoz, Jessica, Giner, Maria Pilar, Christen, Stefan, Moco, Sofia, Leleu, Marion, de Leval, Laurence, Koch, Ute, Trumpp, Andreas, Sakamoto, Kei, Beermann, Friedrich, Radtke, Freddy

“…Although c‐Myc is essential for melanocyte development, its role in cutaneous melanoma, the most aggressive skin cancer, is only partly understood. Here we…”
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Metabolomics technologies and metabolite identification by Moco, Sofia, Vervoort, Jacques, Moco, Sofia, Bino, Raoul J., De Vos, Ric C.H., Bino, Raoul

“…Metabolomics studies rely on the analysis of the multitude of small molecules (metabolites) present in a biological system. Most commonly, metabolomics is…”
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In Vitro Gut Metabolism of [U‐13C]‐Quinic Acid, The Other Hydrolysis Product of Chlorogenic Acid by Naranjo Pinta, Martine, Montoliu, Ivan, Aura, Anna‐Marja, Seppänen‐Laakso, Tuulikki, Barron, Denis, Moco, Sofia

“…Scope Quinic acid in its free form is broadly abundant in plants, and can accumulate in copious amounts in coffee, tea, and certain fruits. However, it has…”
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Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase Intracellular NAD+ by Generating Dihydronicotinamide Riboside by Ciarlo, Eleonora, Joffraud, Magali, Hayat, Faisal, Giner, Maria Pilar, Giroud-Gerbetant, Judith, Sanchez-Garcia, Jose Luis, Rumpler, Marie, Moco, Sofia, Migaud, Marie E., Cantó, Carles

“…Through evolution, eukaryote organisms have developed the ability to use different molecules as independent precursors to generate nicotinamide adenine…”
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Liquid Chromatography-Mass Spectrometry-Based Metabolome Database for Tomato by Moco, Sofia, Bino, Raoul J, Vorst, Oscar, Verhoeven, Harrie A, Groot, Joost de, Beek, Teris A. van, Vervoort, Jacques, Vos, C.H. Ric de

“…For the description of the metabolome of an organism, the development of common metabolite databases is of utmost importance. Here we present the Metabolome…”
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