Search Results - "Mockridge, C I"

Detection of candidate biomarkers of prostate cancer progression in serum: a depletion-free 3D LC/MS quantitative proteomics pilot study by Larkin, S E T, Johnston, H E, Jackson, T R, Jamieson, D G, Roumeliotis, T I, Mockridge, C I, Michael, A, Manousopoulou, A, Papachristou, E K, Brown, M D, Clarke, N W, Pandha, H, Aukim-Hastie, C L, Cragg, M S, Garbis, S D, Townsend, P A

“…Background: Prostate cancer (PCa) is the most common male cancer in the United Kingdom and we aimed to identify clinically relevant biomarkers corresponding to…”
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Analysis of VH Genes Used by Neoplastic B Cells in Endemic Burkitt's Lymphoma Shows Somatic Hypermutation and Intraclonal Heterogeneity by Chapman, Caroline J., Mockridge, C.Ian, Rowe, Martin, Rickinson, Alan B., Stevenson, Freda K.

“…Tumor cell lines from six typical cases of endemic Epstein-Barr virus (EBV) genome-positive Burkitt's lymphoma (BL) have been investigated for usage and…”
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Sequence analysis of V4–34‐encoded antibodies from single B cells of two patients with systemic lupus erythematosus (SLE) by MOCKRIDGE, C. I, CHAPMAN, C. J, SPELLERBERG, M. B, SHETH, B, FLEMING, T. P, ISENBERG, D. A, STEVENSON, F. K

“…SLE is an autoimmune disease characterized by the presence of autoantibodies against double‐stranded (ds)DNA. A large proportion (approx. 40%) of patients with…”
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IgM-expressing Waldenstrom's macroglobulinemia tumor cells reveal a potential for isotype switch events in vivo by Babbage, G, Townsend, M, Zojer, N, Mockridge, I C, Garand, R, Barlogie, B, Shaughnessy, Jr, J, Stevenson, F K, Sahota, S S

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Tracking of the V4–34 (VH4–21) gene in human tonsil reveals clonal isotype switch events and a highly variable degree of somatic hypermutation by CHAPMAN, C. J., MOCKRIDGE, C. I., HAMBLIN, T. J., STEVENSON, F. K.

“…The V4–34 (VH4–21) gene has been found to encode certain IgM autoantibodies, and is mandatory for pathological IgM anti‐erythrocyte antibodies of I/i…”
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Tumor cells of hairy cell leukemia express multiple clonally related immunoglobulin isotypes via RNA splicing by Forconi, Francesco, Sahota, Surinder S., Raspadori, Donatella, Mockridge, Christopher I., Lauria, Francesco, Stevenson, Freda K.

“…Hairy cell leukemia (HCL) derives from a mature B cell and expresses markers associated with activation. Analysis of immunoglobulin variable region genes has…”
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Common Patterns of B Cell Perturbation and Expanded V4-34 Immunoglobulin Gene Usage in Autoimmunity and Infection by Ian Mockridge, C., Rahman, Anisur, Buchan, Sarah, Hamblin, Terry, Isenberg, David A., Stevenson, Freda K., Potter, Kathleen N.

“…Features of the lymphocyte population in systemic lupus erythematosus (SLE) include a disordered B cell profile and production of autoantibodies. An additional…”
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Disturbances in peripheral blood B cell subpopulations in autoimmune patients by Potter, K N, Mockridge, C I, Rahman, A, Buchan, S, Hamblin, T, Davidson, B, Isenberg, D A, Stevenson, F K

“…A variety of cell surface markers are being used to identify B cell subpopulations in peripheral blood. Currently at least eight subpopulationshave been…”
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Sequence analysis of V(4-34)-encoded antibodies from single B cells of two patients with systemic lupus erythematosus (SLE) by Mockridge, C I, Chapman, C J, Spellerberg, M B, Sheth, B, Fleming, T P, Isenberg, D A, Stevenson, F K

“…SLE is an autoimmune disease characterized by the presence of autoantibodies against double-stranded (ds)DNA. A large proportion (approx. 40%) of patients with…”
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Measurement of human corticosteroid binding globulin by enzyme-linked immunoassay by Fantl, V E, Wang, D Y, Mockridge, C I

“…Thirteen monoclonal antibodies have been raised against corticosteroid binding globulin (CBG). From four of those with highest affinity for the antigen, two…”
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Use of phage surface expression to analyze regions of human V4-34(VH4- 21)-encoded IgG autoantibody required for recognition of DNA: no involvement of the 9G4 idiotope by Mockridge, CI, Chapman, CJ, Spellerberg, MB, Isenberg, DA, Stevenson, FK

“…The V4-34 gene encodes the majority of autoanti-red cell Abs of I/i specificity. It also encodes a proportion of autoanti-DNA Abs found in patients with…”
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Use of a phage expression system to produce Fabs from human autoanti-DNA antibodies encoded by the VH4-21 gene segment by Chapman, C J, Mockridge, C I, Spellerberg, M B, Isenberg, D A, Hamblin, T J, Stevenson, F K

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Radioimmunoassayable insulin-like growth factor-I in human breast cyst fluid by Wang, D Y, Hamed, H, Mockridge, C I, Fentiman, I S

“…insulin-like growth factor-I (IGF-I) was measured in breast cyst fluid and serum collected at the same time. In addition, epidermal growth factor (EGF) was…”
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Urinary epidermal growth factor excretion and breast cancer risk by Wang, D Y, Mockridge, C I, Fantl, V E, de Stavola, B, Allen, D S, Thomas, B S, Moore, J W, Bulbrook, R D, Gravelle, I H, Kwa, H G

“…The amount of urinary epidermal growth factor (EGF) excreted was determined in 350 normal women of whom 37 subsequently developed breast cancer. These were a…”
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Phage surface expression for analysis of recognition sites of human autoantibodies: comparison of single chain Fv and Fab by Chapman, C J, Mockridge, C I, Spellerberg, M B, Zhu, D, Stevenson, F K

“…Human autoantibodies can mediate the pathology of autoimmune disease. To plan therapeutic intervention based on inhibition of binding to autoantigen, it is…”
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Antibodies Selected from Combinatorial Libraries Block a Tumor Antigen That Plays a Key Role in Immunomodulation by McWhirter, John R., Kretz-Rommel, Anke, Saven, Alan, Maruyama, Toshiaki, Potter, Kathleen N., Mockridge, C. Ian, Ravey, E. Prenn, Qin, Fenghua, Bowdish, Katherine S.

“…We searched for cell-surface-associated proteins overexpressed on B cell chronic lymphocytic leukemia (CLL) to use as therapeutic antibody targets. Antibodies…”
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Structural and Functional Features of the B-Cell Receptor in IgG-Positive Chronic Lymphocytic Leukemia by POTTER, Kathleen N, MOCKRIDGE, C. Ian, NEVILLE, Louise, WHEATLEY, Isla, SCHENK, Michael, ORCHARD, Jennifer, DUNCOMBE, Andrew S, PACKHAM, Graham, STEVENSON, Freda K

“…Purpose: To determine the origin and relationship of the rare IgG + variant of chronic lymphocytic leukemia (CLL) to the two common IgM + IgD + subsets that…”
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Use of phage surface expression to analyze regions of a human V sub(4-34)(V sub(H)4-21)-encoded IgG autoantibody required for recognition of DNA. No involvement of the 9G4 idiotope by Mockridge, C I, Chapman, C J, Spellerberg, M B, Isenberg, DA, Stevenson, F K

“…The V sub(4-34) gene encodes the majority of autoanti-red cell Abs of I /i specificity. It also encodes a proportion of autoanti-DNA Abs found in patients with…”
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Tracking of the V sub(4-34) (V sub(H)4-21) gene in human tonsil reveals clonal isotype switch events and a highly variable degree of somatic hypermutation by Chapman, C J, Mockridge, C I, Hamblin, T J, Stevenson, F K

“…The V sub(4-34) (V sub(H)4-21) gene has been found to encode certain IgM autoantibodies, and is mandatory for pathological IgM anti-erythrocyte antibodies of…”
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Analyis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity by CHAPMAN, C. J, MOCKRIDGE, C. I, ROWE, M, RICKINSON, A. B, STEVENSON, F. K

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