Search Results - "Mockeliūnas, Laurynas"

Reproducibility in pharmacometrics applied in a phase III trial of BCG-vaccination for COVID-19 by van Wijk, Rob C., Mockeliunas, Laurynas, van den Hoogen, Gerben, Upton, Caryn M., Diacon, Andreas H., Simonsson, Ulrika S. H.

“…Large clinical trials often generate complex and large datasets which need to be presented frequently throughout the trial for interim analysis or to inform a…”
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Response of Tradescantia plants to oxidative stress induced by heavy metal pollution of soils from industrial areas by Šiukšta, Raimondas, Bondzinskaitė, Skaistė, Kleizaitė, Violeta, Žvingila, Donatas, Taraškevičius, Ričardas, Mockeliūnas, Laurynas, Stapulionytė, Asta, Mak, Kristina, Čėsnienė, Tatjana

“…Numerous investigations have demonstrated that even soil in which concentrations of individual elements do not exceed permissible limits can cause harmful…”
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Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double-blind, randomised, controlled, phase 3 trial by Upton, Caryn M., van Wijk, Rob C., Mockeliunas, Laurynas, Simonsson, Ulrika S.H., McHarry, Kirsten, van den Hoogen, Gerben, Muller, Chantal, von Delft, Arne, van der Westhuizen, Helene-Mari, van Crevel, Reinout, Walzl, Gerhard, Baptista, Pedro M., Peter, Jonathan, Diacon, Andreas H.

“…BCG vaccination prevents severe childhood tuberculosis (TB) and was introduced in South Africa in the 1950s. It is hypothesised that BCG trains the innate…”
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Standards for model-based early bactericidal activity analysis and sample size determination in tuberculosis drug development by Mockeliunas, Laurynas, Faraj, Alan, van Wijk, Rob C, Upton, Caryn M, van den Hoogen, Gerben, Diacon, Andreas H, Simonsson, Ulrika S H

“…A critical step in tuberculosis (TB) drug development is the Phase 2a early bactericidal activity (EBA) study which informs if a new drug or treatment has…”
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Derivation and Clinical Utility of Safety Targets for Linezolid-Related Adverse Events in Drug-Resistant Tuberculosis Treatment by Keutzer, Lina, Mockeliunas, Laurynas, Sturkenboom, Marieke G. G, Bolhuis, Mathieu S, Akkerman, Onno W, Simonsson, Ulrika S. H

“…Long-term usage of linezolid can result in adverse events such as peripheral neuropathy, anemia and thrombocytopenia. Therapeutic drug monitoring data from 75…”
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Seasonal influence on respiratory tract infection severity including COVID-19 quantified through Markov Chain modeling by van Wijk, Rob C, Mockeliunas, Laurynas, Upton, Caryn M, Peter, Jonathan, Diacon, Andreas H, Simonsson, Ulrika S H

“…Respiratory tract infections (RTIs) are a burden to global health, but their characterization is complicated by the influence of seasonality on incidence and…”
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Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis by Mockeliunas, Laurynas, Keutzer, Lina, Sturkenboom, Marieke G G, Bolhuis, Mathieu S, Hulskotte, Lotte M G, Akkerman, Onno W, Simonsson, Ulrika S H

“…Linezolid is an efficacious medication for the treatment of drug-resistant tuberculosis but has been associated with serious safety issues that can result in…”
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Risk Factors for COVID-19 and Respiratory Tract Infections during the Coronavirus Pandemic by Mockeliunas, Laurynas, van Wijk, Rob C, Upton, Caryn M, Peter, Jonathan, Diacon, Andreas H, Simonsson, Ulrika S H

“…(1) Background: Some individuals are more susceptible to developing respiratory tract infections (RTIs) or coronavirus disease (COVID-19) than others. The aim…”
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OA-83 Early bactericidal activity of meropenem, ertapenem, amoxicillin/clavulanate and optimized rifampicin in pulmonary tuberculosis by Upton, Caryn, Jager, Veronique De, Simonsson, Ulrika, Mockeliunas, Laurynas, Mabuka, Thabo, Lelievre, Joel, Sharma, Raman, Chen, Chao, Barros, David, Diacon, Andreas

“…BackgroundRepurposing established antibiotics for TB has been successful, notably for fluoroquinolones, linezolid, and clofazimine. Meropenem co-administered…”
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