Search Results - "Mockel, M"

R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability by Mosler, Thorsten, Conte, Francesca, Longo, Gabriel M. C., Mikicic, Ivan, Kreim, Nastasja, Möckel, Martin M., Petrosino, Giuseppe, Flach, Johanna, Barau, Joan, Luke, Brian, Roukos, Vassilis, Beli, Petra

“…Transcription poses a threat to genomic stability through the formation of R-loops that can obstruct progression of replication forks. R-loops are…”
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Predicting in-hospital mortality using routine parameters in unselected nonsurgical emergency department patients by Slagman, A., Searle, J., Vollert, J.O., Müller, C., Muller, R., Somasundaram, R., Möckel, M.

“…Background To assure adequate and efficient treatment in the emergency department (ED) despite increasing patient numbers, early risk stratification might be…”
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Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila by Worpenberg, Lina, Paolantoni, Chiara, Longhi, Sara, Mulorz, Miriam M, Lence, Tina, Wessels, Hans‐Hermann, Dassi, Erik, Aiello, Giuseppe, Sutandy, F X Reymond, Scheibe, Marion, Edupuganti, Raghu R, Busch, Anke, Möckel, Martin M, Vermeulen, Michiel, Butter, Falk, König, Julian, Notarangelo, Michela, Ohler, Uwe, Dieterich, Christoph, Quattrone, Alessandro, Soldano, Alessia, Roignant, Jean‐Yves

“…N6‐methyladenosine (m 6 A) regulates a variety of physiological processes through modulation of RNA metabolism. This modification is particularly enriched in…”
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Acute renal haemodynamic effects of radiocontrast media in patients undergoing left ventricular and coronary angiography by Möckel, Martin, Radovic, Milan, Kühnle, York, Combé, Volker, Waigand, Jürgen, Schröder, Sabine, Dietz, Rainer, Frei, Ulrich, Eckardt, Kai-Uwe

“…Background. Tubular toxicity and renal ischaemia have been implicated in the pathogenesis of radiocontrast media induced nephropathy (CIN), but their…”
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Structural basis of human kinesin-8 function and inhibition by Locke, Julia, Joseph, Agnel Praveen, Peña, Alejandro, Möckel, Martin M., Mayer, Thomas U., Topf, Maya, Moores, Carolyn A.

“…Kinesin motors play diverse roles in mitosis and are targets for antimitotic drugs. The clinical significance of these motors emphasizes the importance of…”
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Instant rule-out of suspected non-ST-segment elevation myocardial infarction using high-sensitivity cardiac troponin T with Copeptin versus a single low high-sensitivity cardiac troponin T: findings from a large pooled individual data analysis on 10,329 patients by Giannitsis, Evangelos, Huber, K., Hamm, C. W., Möckel, M.

“…Background Evidence is sparse and inconsistent on the role of a dual marker strategy (DMS) combining Copeptin with cardiac troponin T (cTnT) for instant…”
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The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation by Hildebrandt, Andrea, Brüggemann, Mirko, Rücklé, Cornelia, Boerner, Susan, Heidelberger, Jan B, Busch, Anke, Hänel, Heike, Voigt, Andrea, Möckel, Martin M, Ebersberger, Stefanie, Scholz, Anica, Dold, Annabelle, Schmid, Tobias, Ebersberger, Ingo, Roignant, Jean-Yves, Zarnack, Kathi, König, Julian, Beli, Petra

“…Cells have evolved quality control mechanisms to ensure protein homeostasis by detecting and degrading aberrant mRNAs and proteins. A common source of aberrant…”
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Prognostic value of cardiac troponin T and I elevations in renal disease patients without acute coronary syndromes: a 9-month outcome analysis by MÖCKEL, M, SCHINDLER, R, KNORR, L, MÜLLER, C, HELLER, G. JR, STÖRK, T. V, FREI, U

“…Moderate elevations of cardiac troponin (Tn) T, up to levels presumably diagnostic for minor myocardial damage, are suspected to be false positive in nearly…”
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Pre-anaphase chromosome oscillations are regulated by the antagonistic activities of Cdk1 and PP1 on Kif18A by Häfner, Julia, Mayr, Monika I., Möckel, Martin M., Mayer, Thomas U.

“…Upon congression at the spindle equator, vertebrate chromosomes display oscillatory movements which typically decline as cells progress towards anaphase…”
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Value of cardiac troponin I and T for selection of heart donors and as predictors of early graft failure by Potapov, E V, Ivanitskaia, E A, Loebe, M, Möckel, M, Müller, C, Sodian, R, Meyer, R, Hetzer, R

“…Cardiac troponin I and T (cTnI and cTnT) are sensitive and specific markers of myocardial damage. We evaluated them for the selection of heart donors and as…”
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Diastolic function in various forms of left ventricular hypertrophy: contribution of active Doppler stress echo by Möckel, M, Störk, T

“…It has been known for a long time that healthy athletes can develop left ventricular hypertrophy with typical electrocardiographic and echocardiographic…”
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88: Acute Heart Failure Mortality Prediction Using Copeptin: Results of the Biomarkers in ACute Heart Failure Trial by Peacock, W, Nowak, R, Maisel, A, Di Somma, S, Mockel, M, Mueller, C, Xavier Neath, S, Hartman, O, McCord, J, Anker, S

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Synthesis and Biological Evaluation of Optimized Inhibitors of the Mitotic Kinesin Kif18A by Braun, Joachim, Möckel, Martin M, Strittmatter, Tobias, Marx, Andreas, Groth, Ulrich, Mayer, Thomas U

“…The mitotic spindle, a highly dynamic structure composed of microtubules, mediates the segregation of the previously duplicated genome into the two nascent…”
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What is the importance of biomarkers in the intensive care unit? by Möckel, M

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Chemical Genetics Approach to Engineer Kinesins with Sensitivity towards a Small-Molecule Inhibitor of Eg5 by Möckel, Martin M., Hund, Corinna, Mayer, Thomas U.

“…Due to their fast and often reversible mode of action, small molecules are ideally suited to dissect biological processes. Yet, the validity of small‐molecule…”
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Possible mechanisms behind cardiac troponin elevations by Hammarsten, Ola, Mair, Johannes, Möckel, Martin, Lindahl, Bertil, Jaffe, Allan S.

“…Cardiac-specific troponins are elevated in blood following cardiac injury and are the preferred diagnostic biomarkers when acute myocardial infarction is…”
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Xenopus laevis Kif18A is a highly processive kinesin required for meiotic spindle integrity by Möckel, Martin M, Heim, Andreas, Tischer, Thomas, Mayer, Thomas U

“…The assembly and functionality of the mitotic spindle depends on the coordinated activities of microtubule-associated motor proteins of the dynein and kinesin…”
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Severe panarteritis associated with drug abuse by MÖCKEL, M, KAMPF, D, LOBECK, H, FREI, U

“…A case of panarteritis with purpura fulminans, mononeuritis multiplex, gastrointestinal manifestation and presumably cardiac involvement in a previously…”
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Oral anticoagulation in heart failure complicated by atrial fibrillation: a nationwide routine data study by Pudasaini, S, Jeschke, E, Baberg, H T, Levenson, B, Malzahn, J, Mansky, T, Michels, G, Gunster, C, Mockel, M

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How is cardiac troponin released from injured myocardium? by Mair, Johannes, Lindahl, Bertil, Hammarsten, Ola, Müller, Christian, Giannitsis, Evangelos, Huber, Kurt, Möckel, Martin, Plebani, Mario, Thygesen, Kristian, Jaffe, Allan S

“…Cardiac troponin I and cardiac troponin T are nowadays the criterion biomarkers for the laboratory diagnosis of acute myocardial infarction due to their very…”
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