Search Results - "Mock, Beverly"

Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex by Calabrese, David R., Chen, Xiang, Leon, Elena C., Gaikwad, Snehal M., Phyo, Zaw, Hewitt, William M., Alden, Stephanie, Hilimire, Thomas A., He, Fahu, Michalowski, Aleksandra M., Simmons, John K., Saunders, Lindsey B., Zhang, Shuling, Connors, Daniel, Walters, Kylie J., Mock, Beverly A., Schneekloth, John S.

“…G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the promoter regions of oncogenes, such as MYC , and regulate gene expression…”
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The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription by Malik, Navdeep, Yan, Hualong, Moshkovich, Nellie, Palangat, Murali, Yang, Howard, Sanchez, Vanesa, Cai, Zhuo, Peat, Tyler J., Jiang, Shunlin, Liu, Chengyu, Lee, Maxwell, Mock, Beverly A., Yuspa, Stuart H., Larson, Daniel, Wakefield, Lalage M., Huang, Jing

“…Translation and transcription are frequently dysregulated in cancer. These two processes are generally regulated by distinct sets of factors. The CBFB gene,…”
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Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression by Felsenstein, Kenneth M., Saunders, Lindsey B., Simmons, John K., Leon, Elena, Calabrese, David R., Zhang, Shuling, Michalowski, Aleksandra, Gareiss, Peter, Mock, Beverly A., Schneekloth, John S.

“…The transcription factor MYC plays a pivotal role in cancer initiation, progression, and maintenance. However, it has proven difficult to develop small…”
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The transcription factor MZF1 differentially regulates murine Mtor promoter variants linked to tumor susceptibility by Zhang, Shuling, Shi, Wei, Ramsay, Edward S., Bliskovsky, Valery, Eiden, Adrian Max, Connors, Daniel, Steinsaltz, Matthew, DuBois, Wendy, Mock, Beverly A.

“…Mechanistic target of rapamycin (MTOR) is a highly conserved serine/threonine kinase that critically regulates cell growth, proliferation, differentiation, and…”
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A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins by Lu, Xiuxiu, Chandravanshi, Monika, Sabbasani, Venkata R., Gaikwad, Snehal, Hughitt, V. Keith, Gyabaah-Kessie, Nana, Scroggins, Bradley T., Das, Sudipto, Myint, Wazo, Clapp, Michelle E., Schwieters, Charles D., Dyba, Marzena A., Bolhuis, Derek L., Koscielniak, Janusz W., Andresson, Thorkell, Emanuele, Michael J., Brown, Nicholas G., Matsuo, Hiroshi, Chari, Raj, Citrin, Deborah E., Mock, Beverly A., Swenson, Rolf E., Walters, Kylie J.

“…Proteasome subunit hRpn13 is partially proteolyzed in certain cancer cell types to generate hRpn13 Pru by degradation of its UCHL5/Uch37-binding DEUBAD domain…”
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B cell-specific deficiencies in mTOR limit humoral immune responses by Zhang, Shuling, Pruitt, Margaret, Tran, Dena, Du Bois, Wendy, Zhang, Ke, Patel, Rushi, Hoover, Shelley, Simpson, R Mark, Simmons, John, Gary, Joy, Snapper, Clifford M, Casellas, Rafael, Mock, Beverly A

“…Generation of high-affinity Abs in response to Ags/infectious agents is essential for developing long-lasting immune responses. B cell maturation and Ab…”
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Conditional deletion of mTOR discloses its essential role in early B‐cell development by Zhang, Shuling, Dubois, Wendy, Feng, Xingmin, Nguyen, Joe T., Young, Neal S., Mock, Beverly A.

“…Mechanistic target of rapamycin (mTOR) is a serine‐threonine kinase and central regulator of cell growth, differentiation, and survival. mTOR is commonly…”
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Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression by Wu, J. Julie, Liu, Jie, Chen, Edmund B., Wang, Jennifer J., Cao, Liu, Narayan, Nisha, Fergusson, Marie M., Rovira, Ilsa I., Allen, Michele, Springer, Danielle A., Lago, Cory U., Zhang, Shuling, DuBois, Wendy, Ward, Theresa, deCabo, Rafael, Gavrilova, Oksana, Mock, Beverly, Finkel, Toren

“…We analyzed aging parameters using a mechanistic target of rapamycin (mTOR) hypomorphic mouse model. Mice with two hypomorphic (mTORΔ/Δ) alleles are viable but…”
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Use of CRISPR-based screens to identify mechanisms of chemotherapy resistance by Alyateem, George, Wade, Heidi M., Bickert, Aaron A., Lipsey, Crystal C., Mondal, Priya, Smith, MacKinzie D., Labib, Rania M., Mock, Beverly A., Robey, Robert W., Gottesman, Michael M.

“…Despite the development of new classes of targeted anti-cancer drugs, the curative treatment of metastatic solid tumors remains out of reach owing to the…”
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The Reign of Antibodies: A Celebration of and Tribute to Michael Potter and His Homogeneous Immunoglobulin Workshops by Gearhart, Patricia J, Mock, Beverly A, Casellas, Rafael, Cancro, Michael P

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Fatty acid oxidation is required for embryonic stem cell survival during metabolic stress by Yan, Hualong, Malik, Navdeep, Kim, Young-Im, He, Yunlong, Li, Mangmang, Dubois, Wendy, Liu, Huaitian, Peat, Tyler J, Nguyen, Joe T, Tseng, Yu-Chou, Ayaz, Gamze, Alzamzami, Waseem, Chan, King, Andresson, Thorkell, Tessarollo, Lino, Mock, Beverly A, Lee, Maxwell P, Huang, Jing

“…Metabolic regulation is critical for the maintenance of pluripotency and the survival of embryonic stem cells (ESCs). The transcription factor Tfcp2l1 has…”
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Conventional Co-Housing Modulates Murine Gut Microbiota and Hematopoietic Gene Expression by Chen, Jichun, Zhang, Shuling, Feng, Xingmin, Wu, Zhijie, Dubois, Wendy, Thovarai, Vishal, Ahluwalia, Sonia, Gao, Shouguo, Chen, Jinguo, Peat, Tyler, Sen, Shurjo K, Trinchieri, Giorgio, Young, Neal S, Mock, Beverly A

“…Specific-pathogen-free (SPF) mice have improved hematopoietic characteristics relative to germ-free mice, however, it is not clear whether improvements in…”
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Molecular Pathways: Increased Susceptibility to Infection Is a Complication of mTOR Inhibitor Use in Cancer Therapy by Eiden, Adrian M, Zhang, Shuling, Gary, Joy M, Simmons, John K, Mock, Beverly A

“…As one of the earliest examples of "chemical biology," the M: echanistic T: arget of R: apamycin (mTOR) protein and its chemical inhibitors have been…”
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Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production by Zhang, Shuling, Readinger, Julie A., DuBois, Wendy, Janka-Junttila, Mirkka, Robinson, Richard, Pruitt, Margaret, Bliskovsky, Val, Wu, Julie Z., Sakakibara, Kaori, Patel, Jyoti, Parent, Carole A., Tessarollo, Lino, Schwartzberg, Pamela L., Mock, Beverly A.

“…Mammalian TOR (mTOR) regulates cell growth, proliferation, and migration. Because mTOR knock-outs are embryonic lethal, we generated a viable hypomorphic mouse…”
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Characterization of clinically used oral antiseptics as quadruplex-binding ligands by Calabrese, David R, Zlotkowski, Katherine, Alden, Stephanie, Hewitt, William M, Connelly, Colleen M, Wilson, Robert M, Gaikwad, Snehal, Chen, Lu, Guha, Rajarshi, Thomas, Craig J, Mock, Beverly A, Schneekloth, John S

“…Abstract Approaches to characterize the nucleic acid-binding properties of drugs and druglike small molecules are crucial to understanding the behavior of…”
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Drug combinations identified by high-throughput screening promote cell cycle transition and upregulate Smad pathways in myeloma by Peat, Tyler J., Gaikwad, Snehal M., Dubois, Wendy, Gyabaah-Kessie, Nana, Zhang, Shuling, Gorjifard, Sayeh, Phyo, Zaw, Andres, Megan, Hughitt, V. Keith, Simpson, R. Mark, Miller, Margaret A., Girvin, Andrew T., Taylor, Andrew, Williams, Daniel, D'Antonio, Nelson, Zhang, Yong, Rajagopalan, Adhithi, Flietner, Evan, Wilson, Kelli, Zhang, Xiaohu, Shinn, Paul, Klumpp-Thomas, Carleen, McKnight, Crystal, Itkin, Zina, Chen, Lu, Kazandijian, Dickran, Zhang, Jing, Michalowski, Aleksandra M., Simmons, John K., Keats, Jonathan, Thomas, Craig J., Mock, Beverly A.

“…Drug resistance and disease progression are common in multiple myeloma (MM) patients, underscoring the need for new therapeutic combinations. A high-throughput…”
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Cooperative Targets of Combined mTOR/HDAC Inhibition Promote MYC Degradation by Simmons, John K, Michalowski, Aleksandra M, Gamache, Benjamin J, DuBois, Wendy, Patel, Jyoti, Zhang, Ke, Gary, Joy, Zhang, Shuling, Gaikwad, Snehal, Connors, Daniel, Watson, Nicholas, Leon, Elena, Chen, Jin-Qiu, Kuehl, W Michael, Lee, Maxwell P, Zingone, Adriana, Landgren, Ola, Ordentlich, Peter, Huang, Jing, Mock, Beverly A

“…Cancer treatments often require combinations of molecularly targeted agents to be effective. mTORi (rapamycin) and HDACi (MS-275/entinostat) inhibitors have…”
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A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma by Gaikwad, Snehal M., Phyo, Zaw, Arteaga, Anaisa Quintanilla, Gorjifard, Sayeh, Calabrese, David R., Connors, Daniel, Huang, Jing, Michalowski, Aleksandra M., Zhang, Shuling, Liu, Zheng-Gang, Schneekloth, John S., Mock, Beverly A.

“…New approaches to target MYC include the stabilization of a guanine-rich, G-quadruplex (G4) tertiary DNA structure in the NHE III region of its promoter…”
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Hypomorphic mTOR Downregulates CDK6 and Delays Thymic Pre-T LBL Tumorigenesis by Gary, Joy M., Simmons, John K., Xu, Jinfei, Zhang, Shuling, Peat, Tyler J., Watson, Nicholas, Gamache, Benjamin J., Zhang, Ke, Kovalchuk, Alexander L., Michalowski, Aleksandra M., Chen, Jin-Qiu, Thaiwong, Tuddow, Kiupel, Matti, Gaikwad, Snehal, Etienne, Maudeline, Simpson, R. Mark, Dubois, Wendy, Testa, Joseph R., Mock, Beverly A.

“…PI3K/AKT/mTOR pathway hyperactivation is frequent in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL). To model inhibition of mTOR, pre–T-cell…”
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Attenuation of immune‐mediated bone marrow damage in conventionally housed mice by Li, Jun, Dubois, Wendy, Thovarai, Vishal, Wu, Zhijie, Feng, Xingmin, Peat, Tyler, Zhang, Shuling, Sen, Shurjo K., Trinchieri, Giorgio, Chen, Jichun, Mock, Beverly A., Young, Neal S.

“…In humans, bone marrow (BM) failure syndromes, both constitutional and acquired, predispose to myeloid malignancies. We have modeled acquired immune aplastic…”
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