Search Results - "Mocharla, Vani P."

[18 F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease by Xia, Chun-Fang, Arteaga, Janna, Chen, Gang, Gangadharmath, Umesh, Gomez, Luis F, Kasi, Dhanalakshmi, Lam, Chung, Liang, Qianwa, Liu, Changhui, Mocharla, Vani P, Mu, Fanrong, Sinha, Anjana, Su, Helen, Szardenings, A. Katrin, Walsh, Joseph C, Wang, Eric, Yu, Chul, Zhang, Wei, Zhao, Tieming, Kolb, Hartmuth C

“…Abstract Objective We wished to develop a highly selective positron emission tomography (PET) imaging agent targeting PHF-tau in human Alzheimer's disease (AD)…”
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A highly selective and specific PET tracer for imaging of tau pathologies by Zhang, Wei, Arteaga, Janna, Cashion, Daniel K, Chen, Gang, Gangadharmath, Umesh, Gomez, Luis F, Kasi, Dhanalakshmi, Lam, Chung, Liang, Qianwa, Liu, Changhui, Mocharla, Vani P, Mu, Fanrong, Sinha, Anjana, Szardenings, A Katrin, Wang, Eric, Walsh, Joseph C, Xia, Chunfang, Yu, Chul, Zhao, Tieming, Kolb, Hartmuth C

“…Senile plaques and neurofibrillary tangles are prominent neuropathological hallmarks in Alzheimer's disease and are considered to be targets for therapeutic…”
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Integrated Microfluidics for Parallel Screening of an In Situ Click Chemistry Library by Wang, Jinyi, Sui, Guodong, Mocharla, Vani P., Lin, Rachel J., Phelps, Michael E., Kolb, Hartmuth C., Tseng, Hsian-Rong

“…State‐of‐the‐art: Automated chemical reaction circuits have been demonstrated to serve as a miniaturized operation platform for the parallel screening of 32 in…”
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In Situ Click Chemistry: Enzyme-Generated Inhibitors of Carbonic Anhydrase II by Mocharla, Vani P., Colasson, Benoit, Lee, Lac V., Röper, Stefanie, Sharpless, K. Barry, Wong, Chi-Huey, Kolb, Hartmuth C.

“…Target‐guided synthesis: Rather than making and screening thousands of compounds for lead discovery, in situ click chemistry employs the biological target…”
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Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents by Maguire, Casey J, Chen, Zhi, Mocharla, Vani P, Sriram, Madhavi, Strecker, Tracy E, Hamel, Ernest, Zhou, Heling, Lopez, Ramona, Wang, Yifan, Mason, Ralph P, Chaplin, David J, Trawick, Mary Lynn, Pinney, Kevin G

“…The natural products colchicine and combretastatin A-4 ( ) have provided inspiration for the discovery and development of a wide array of derivatives and…”
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Evaluation of [18F]-CP18 as a PET Imaging Tracer for Apoptosis by Su, Helen, Chen, Gang, Gangadharmath, Umesh, Gomez, Luis F., Liang, Qianwa, Mu, Fanrong, Mocharla, Vani P., Szardenings, A Katrin, Walsh, Joseph C., Xia, Chun-Fang, Yu, Chul, Kolb, Hartmuth C.

“…Purpose We identified and validated [ 18 F]-CP18, a DEVD (the caspase 3 substrate recognition motif) containing substrate-based compound as an imaging tracer…”
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Radiolabeled hydroxamate-based matrix metalloproteinase inhibitors: How chemical modifications affect pharmacokinetics and metabolic stability by Hugenberg, Verena, Hermann, Sven, Galla, Fabian, Schäfers, Michael, Wünsch, Bernhard, Kolb, Hartmuth C, Szardenings, Katrin, Lebedev, Artem, Walsh, Joseph C, Mocharla, Vani P, Gangadharmath, Umesh B, Kopka, Klaus, Wagner, Stefan

“…Abstract Introduction Dysregulated MMP expression or activation is associated with several diseases. To study MMP activity in vivo by means of PET a…”
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In Vitro and In Vivo Evaluation of the Caspase-3 Substrate-Based Radiotracer [18F]-CP18 for PET Imaging of Apoptosis in Tumors by Xia, Chun-Fang, Chen, Gang, Gangadharmath, Umesh, Gomez, Luis F., Liang, Qianwa, Mu, Fanrong, Mocharla, Vani P., Su, Helen, Szardenings, A. Katrin, Walsh, Joseph C., Zhao, Tieming, Kolb, Hartmuth C.

“…Purpose A novel caspase-3 substrate-based probe [ 18 F]-CP18 was evaluated as an in vivo positron emission tomography (PET) imaging agent for monitoring…”
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Biodistribution and Radiation Dosimetry of the Carbonic Anhydrase IX Imaging Agent [18 F]VM4-037 Determined from PET/CT Scans in Healthy Volunteers by Doss, Mohan, Kolb, Hartmuth C., Walsh, Joseph C., Mocharla, Vani P., Zhu, Zhihong, Haka, Michael, Alpaugh, R. Katherine, Chen, David Y. T., Yu, Jian Q.

“…Purpose [ 18  F]VM4-037 has been developed as a positron emission tomography (PET) imaging marker to detect carbonic anhydrase IX (CA-IX) overexpression and is…”
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From In Situ to In Vivo: An In Situ Click-Chemistry-Derived Carbonic Anhydrase II Imaging Agent for Positron Emission Tomography by Mocharla, Vani P., Walsh, Joseph C., Padgett, Henry C., Su, Helen, Fueger, Barbara, Weber, Wolfgang A., Czernin, Johannes, Kolb, Hartmuth C.

“…CA II makes a good PET: Discovering positron emission tomography (PET) probes with high target affinities is challenging. PET probe discovery using in situ…”
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From InSitu to In Vivo: An InSitu Click-Chemistry-Derived Carbonic AnhydraseII Imaging Agent for Positron Emission Tomography by Mocharla, Vani P, Walsh, Joseph C, Padgett, Henry C, Su, Helen, Fueger, Barbara, Weber, Wolfgang A, Czernin, Johannes, Kolb, Hartmuth C

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Biodistribution and radiation dosimetry of the integrin marker 18F-RGD-K5 determined from whole-body PET/CT in monkeys and humans by Doss, Mohan, Kolb, Hartmuth C, Zhang, James J, Bélanger, Marie-José, Stubbs, James B, Stabin, Michael G, Hostetler, Eric D, Alpaugh, R Katherine, von Mehren, Margaret, Walsh, Joseph C, Haka, Michael, Mocharla, Vani P, Yu, Jian Q

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Integrated Microfluidics for Parallel Screening of an In Situ Click Chemistry Library by Wang, Jinyi, Sui, Guodong, Mocharla, Vani P., Lin, Rachel J., Phelps, Michael E., Kolb, Hartmuth C., Tseng, Hsian-Rong

“…Klein, aber fein: Automatisierte chemische Reaktionskreisläufe eignen sich für das miniaturisierte parallele Screening von 32 Klick‐Chemie‐Reaktionen in situ…”
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A new anti-tubulin agent containing the benzo[ b]thiophene ring system by Pinney, Kevin G., Bounds, A.Dawn, Dingeman, Koren M., Mocharla, Vani P., Pettit, George R., Bai, Ruoli, Hamel, Ernest

“…A new type of inhibitor of tubulin polymerization was discovered based on the 3-aroyl-2-arylbenzo[ b]thiophene molecular skeleton. The lead compound in this…”
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Preparation of New Anti-Tubulin Ligands through a Dual-Mode, Addition−Elimination Reaction to a Bromo-Substituted α,β-Unsaturated Sulfoxide by Chen, Zhi, Mocharla, Vani P, Farmer, J. Matt, Pettit, George R, Hamel, Ernest, Pinney, Kevin G

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In Situ Click Chemistry: Enzyme-Generated Inhibitors of Carbonic Anhydrase II by Mocharla, Vani P., Colasson, Benoit, Lee, Lac V., Röper, Stefanie, Sharpless, K. Barry, Wong, Chi-Huey, Kolb, Hartmuth C.

“…Das Protein als Reaktor: Statt Tausende von Verbindungen zu synthetisieren und zu testen, um eine Leitstruktur zu finden, nutzt die In‐situ‐Click‐Chemie das…”
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Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agentsDedicated to the memory of Dr. Anjan Ghatak, an inspiring and creative synthetic organic, medicinal chemist who made seminal contributions to the science described in this manuscript.All animal procedures were approved by the University of Texas Southwestern Medical Center Institutional Animal Care and Use Committee under APN101222 and 102169.Electronic supplementary infor by Maguire, Casey J, Chen, Zhi, Mocharla, Vani P, Sriram, Madhavi, Strecker, Tracy E, Hamel, Ernest, Zhou, Heling, Lopez, Ramona, Wang, Yifan, Mason, Ralph P, Chaplin, David J, Trawick, Mary Lynn, Pinney, Kevin G

“…The natural products colchicine and combretastatin A-4 ( CA4 ) have provided inspiration for the discovery and development of a wide array of derivatives and…”
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Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents† †Dedicated to the memory of Dr. Anjan Ghatak, an inspiring and creative synthetic organic, medicinal chemist who made seminal contributions to the science described in this manuscript. ‡ ‡All animal procedures were approved by the University of Texas Southwestern Medical Center Institutional Animal Care and Use Committee under APN101222 and 102169. § §Electronic suppleme by Maguire, Casey J., Chen, Zhi, Mocharla, Vani P., Sriram, Madhavi, Strecker, Tracy E., Hamel, Ernest, Zhou, Heling, Lopez, Ramona, Wang, Yifan, Mason, Ralph P., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.

“…Dihydronaphthalene analogues as potent inhibitors of tubulin polymerization, cytotoxic agents, and vascular disrupting agents (VDAs). The natural products…”
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Biodistribution and Radiation Dosimetry of the Integrin Marker 18 F-RGD-K5 Determined from Whole-Body PET/CT in Monkeys and Humans by Doss, Mohan, Kolb, Hartmuth C., Zhang, James J., Bélanger, Marie-José, Stubbs, James B., Stabin, Michael G., Hostetler, Eric D., Alpaugh, R. Katherine, von Mehren, Margaret, Walsh, Joseph C., Haka, Michael, Mocharla, Vani P., Yu, Jian Q.

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Biodistribution and Radiation Dosimetry of the Integrin Marker ^sup 18^F-RGD-K5 Determined from Whole-Body PET/CT in Monkeys and Humans by Doss, Mohan, Kolb, Hartmuth C, Zhang, James J, Bélanger, Marie-José, Stubbs, James B, Stabin, Michael G, Hostetler, Eric D, Alpaugh, R Katherine, vonMehren, Margaret, Walsh, Joseph C, Haka, Michael, Mocharla, Vani P, Yu, Jian Q

“…2-((2S,5R,8S,11S)-5-benzyl-8-(4-((2S,3R,4R,5R,6S)-6-((2-(4- (3-^sup 18^F-fluoropropyl)-1H-1,2,3-triazol-1-yl)acetamido)methyl)-3,4,…”
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