Search Results - "Moch, Holger"

PD‐L1 expression is regulated by hypoxia inducible factor in clear cell renal cell carcinoma by Ruf, Melanie, Moch, Holger, Schraml, Peter

“…In our study, we demonstrate that ccRCC cell lines with impaired function of pVHL to degrade HIFα express elevated levels of PD‐L1. In vitro analysis provided…”
Get full text

Periostin expression and epithelial-mesenchymal transition in cancer: a review and an update by Morra, Laura, Moch, Holger

“…Periostin, also called osteoblast-specific factor 2, is a secreted cell adhesion protein, which shares a homology with the insect cell adhesion molecule…”
Get full text

Endothelial cell infection and endotheliitis in COVID-19 by Varga, Zsuzsanna, Flammer, Andreas J, Steiger, Peter, Haberecker, Martina, Andermatt, Rea, Zinkernagel, Annelies S, Mehra, Mandeep R, Schuepbach, Reto A, Ruschitzka, Frank, Moch, Holger

“…The mechanisms underlying the disproportionate effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on patients with cardiovascular…”
Get full text

Germinal Centers Determine the Prognostic Relevance of Tertiary Lymphoid Structures and Are Impaired by Corticosteroids in Lung Squamous Cell Carcinoma by Siliņa, Karīna, Soltermann, Alex, Attar, Farkhondeh Movahedian, Casanova, Ruben, Uckeley, Zina M, Thut, Helen, Wandres, Muriel, Isajevs, Sergejs, Cheng, Phil, Curioni-Fontecedro, Alessandra, Foukas, Periklis, Levesque, Mitchell P, Moch, Holger, Linē, Aija, van den Broek, Maries

“…In solid tumors, the presence of lymph node-like structures called tertiary lymphoid structures (TLS) is associated with improved patient survival. However,…”
Get full text

A Clearer View of the Molecular Complexity of Clear Cell Renal Cell Carcinoma by Frew, Ian J, Moch, Holger

“…The von Hippel-Lindau ( VHL ) tumor suppressor gene is mutated as an early event in almost all cases of clear cell renal cell carcinoma (ccRCC), the most…”
Get full text

The single-cell pathology landscape of breast cancer by Jackson, Hartland W., Fischer, Jana R., Zanotelli, Vito R. T., Ali, H. Raza, Mechera, Robert, Soysal, Savas D., Moch, Holger, Muenst, Simone, Varga, Zsuzsanna, Weber, Walter P., Bodenmiller, Bernd

“…Single-cell analyses have revealed extensive heterogeneity between and within human tumours 1 – 4 , but complex single-cell phenotypes and their spatial…”
Get full text

Differential PD-1/LAG-3 expression and immune phenotypes in metastatic sites of breast cancer by Sobottka, Bettina, Moch, Holger, Varga, Zsuzsanna

“…A dual blockade against the novel immune checkpoint inhibitor lymphocyte activation gene-3 (LAG-3) and programmed cell death protein-1 (PD-1) is currently…”
Get full text

Computed Tomography Radiomics Predicts HPV Status and Local Tumor Control After Definitive Radiochemotherapy in Head and Neck Squamous Cell Carcinoma by Bogowicz, Marta, Riesterer, Oliver, Ikenberg, Kristian, Stieb, Sonja, Moch, Holger, Studer, Gabriela, Guckenberger, Matthias, Tanadini-Lang, Stephanie

“…This study aimed to predict local tumor control (LC) after radiochemotherapy of head and neck squamous cell carcinoma (HNSCC) and human papillomavirus (HPV)…”
Get full text

Intratumor heterogeneity in hepatocellular carcinoma by Friemel, Juliane, Rechsteiner, Markus, Frick, Lukas, Böhm, Friederike, Struckmann, Kirsten, Egger, Michèle, Moch, Holger, Heikenwalder, Mathias, Weber, Achim

“…Morphologic intratumor heterogeneity is well known to exist in hepatocellular carcinoma (HCC), but very few systematic analyses of this phenomenon have been…”
Get full text

An Immune Atlas of Clear Cell Renal Cell Carcinoma by Chevrier, Stéphane, Levine, Jacob Harrison, Zanotelli, Vito Riccardo Tomaso, Silina, Karina, Schulz, Daniel, Bacac, Marina, Ries, Carola Hermine, Ailles, Laurie, Jewett, Michael Alexander Spencer, Moch, Holger, van den Broek, Maries, Beisel, Christian, Stadler, Michael Beda, Gedye, Craig, Reis, Bernhard, Pe’er, Dana, Bodenmiller, Bernd

“…Immune cells in the tumor microenvironment modulate cancer progression and are attractive therapeutic targets. Macrophages and T cells are key components of…”
Get full text

Two distinct immunopathological profiles in autopsy lungs of COVID-19 by Nienhold, Ronny, Ciani, Yari, Koelzer, Viktor H., Tzankov, Alexandar, Haslbauer, Jasmin D., Menter, Thomas, Schwab, Nathalie, Henkel, Maurice, Frank, Angela, Zsikla, Veronika, Willi, Niels, Kempf, Werner, Hoyler, Thomas, Barbareschi, Mattia, Moch, Holger, Tolnay, Markus, Cathomas, Gieri, Demichelis, Francesca, Junt, Tobias, Mertz, Kirsten D.

“…Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a…”
Get full text

Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer by Schödel, Johannes, Grampp, Steffen, Maher, Eamonn R, Moch, Holger, Ratcliffe, Peter J, Russo, Paul, Mole, David R

“…Abstract Context Renal cancer is a common urologic malignancy, and therapeutic options for metastatic disease are limited. Most clear cell renal cell…”
Get full text

Biomarker discovery for renal cancer stem cells by Corrò, Claudia, Moch, Holger

“…Characterised by high intra‐ and inter‐tumor heterogeneity, metastatic renal cell carcinoma (RCC) is resistant to chemo‐ and radiotherapy. Therefore, the…”
Get full text

The 2022 World Health Organization Classification of Tumors of the Urinary System and Male Genital Organs—Part B: Prostate and Urinary Tract Tumors by Netto, George J., Amin, Mahul B., Berney, Daniel M., Compérat, Eva M., Gill, Anthony J., Hartmann, Arndt, Menon, Santosh, Raspollini, Maria R., Rubin, Mark A., Srigley, John R., Hoon Tan, Puay, Tickoo, Satish K., Tsuzuki, Toyonori, Turajlic, Samra, Cree, Ian, Moch, Holger

“…The fifth edition of the World Health Organization (WHO) “Blue Book” brings a comprehensive update on the terminology, epidemiology, pathogenesis,…”
Get full text

Cytoplasmic ADP-ribosylation levels correlate with markers of patient outcome in distinct human cancers by Aimi, Fabio, Moch, Holger, Schraml, Peter, Hottiger, Michael O.

“…ADP-ribosylation (ADPR) is a posttranslational modification whose importance in oncology keeps increasing due to frequent use of PARP inhibitors (PARPi) to…”
Get full text

CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer by Tallón de Lara, Paulino, Castañón, Héctor, Vermeer, Marijne, Núñez, Nicolás, Silina, Karina, Sobottka, Bettina, Urdinez, Joaquín, Cecconi, Virginia, Yagita, Hideo, Movahedian Attar, Farkhondeh, Hiltbrunner, Stefanie, Glarner, Isabelle, Moch, Holger, Tugues, Sònia, Becher, Burkhard, van den Broek, Maries

“…Some breast tumors metastasize aggressively whereas others remain dormant for years. The mechanism governing metastatic dormancy remains largely unknown…”
Get full text

The expression of PD-L1 in salivary gland carcinomas by Vital, Domenic, Ikenberg, Kristian, Moch, Holger, Rössle, Matthias, Huber, Gerhard F.

“…Objective was to analyze the role of PD-L1 and its relation to demographic, patho-clinical and outcome parameters in salivary gland carcinoma (SGC) patients…”
Get full text

Mitochondrial Elongation and ROS-Mediated Apoptosis in Prostate Cancer Cells under Therapy with Apalutamide and Complex I Inhibitor by Baumgartner, Valentin, Schaer, Dominik, Moch, Holger, Salemi, Souzan, Eberli, Daniel

“…Metabolic reprogramming and mitochondrial dynamics are pivotal in prostate cancer (PCa) progression and treatment resistance, making them essential targets for…”
Get full text

Synthetic lethality between BRCA1 deficiency and poly(ADP-ribose) polymerase inhibition is modulated by processing of endogenous oxidative DNA damage by Giovannini, Sara, Weller, Marie-Christine, Repmann, Simone, Moch, Holger, Jiricny, Josef

“…Poly(ADP-ribose) polymerases (PARPs) facilitate the repair of DNA single-strand breaks (SSBs). When PARPs are inhibited, unrepaired SSBs colliding with…”
Get full text

Re: Svetlana Avulova, John C. Cheville, Christine M. Lohse, et al. Grading Chromophobe Renal Cell Carcinoma: Evidence for a Four-tiered Classification Incorporating Coagulative Tumor Necrosis. Eur Urol 2021;79:225–31 by Ohashi, Riuko, Hartmann, Arndt, Martignoni, Guido, Moch, Holger

Get full text