Search Results - "Moccia, Luca"

Discovery of a Potent, Selective T‑type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies by Bezençon, Olivier, Heidmann, Bibia, Siegrist, Romain, Stamm, Simon, Richard, Sylvia, Pozzi, Davide, Corminboeuf, Olivier, Roch, Catherine, Kessler, Melanie, Ertel, Eric A., Reymond, Isabelle, Pfeifer, Thomas, de Kanter, Ruben, Toeroek-Schafroth, Michael, Moccia, Luca G., Mawet, Jacques, Moon, Richard, Rey, Markus, Capeleto, Bruno, Fournier, Elvire

“…We report here the discovery and pharmacological characterization of N-(1-benzyl-1H-pyrazol-3-yl)-2-phenylacetamide derivatives as potent, selective,…”
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Milestones to the Discovery of T-type Calcium Channel Blockers for the Treatment of Generalized Epilepsies by Bezençon, Olivier, Siegrist, Romain, Heidmann, Bibia, Pozzi, Davide, Stamm, Simon, Remeň, Luboš, Richard, Sylvia, Simons, Lloyd, Gaston, Rick, Downing, Dennis, Grisostomi, Corinna, Roch, Catherine, Kessler, Melanie, Gatfield, John, Moon, Richard, Pfeifer, Thomas, Mosbacher, Johannes, Reymond, Isabelle, Ertel, Eric A, de Kanter, Ruben, Capeleto, Bruno, Fournier, Elvire, Rey, Markus, Moccia, Luca, Toeroek-Schafroth, Michael, Roscher, René, Schindelholz, Benno

“…We describe the discovery and optimization of new, brain-penetrant T-type calcium channel blockers. We present optimized compounds with excellent efficacy in a…”
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Design and Synthesis of Novel Tricyclic Benzoxazines as Potent 5-HT1A/B/D Receptor Antagonists Leading to the Discovery of 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide (GSK588045) by Bromidge, Steven M, Arban, Roberto, Bertani, Barbara, Bison, Silvia, Borriello, Manuela, Cavanni, Paolo, Dal Forno, Giovanna, Di-Fabio, Romano, Donati, Daniele, Fontana, Stefano, Gianotti, Massimo, Gordon, Laurie J, Granci, Enrica, Leslie, Colin P, Moccia, Luca, Pasquarello, Alessandra, Sartori, Ilaria, Sava, Anna, Watson, Jeannette M, Worby, Angela, Zonzini, Laura, Zucchelli, Valeria

“…Bioisoteric replacement of the metabolically labile N-methyl amide group of a series of benzoxazinones with small heterocyclic rings has led to novel series of…”
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Design and Synthesis of Novel Tricyclic Benzoxazines as Potent 5-HT 1A/B/D Receptor Antagonists Leading to the Discovery of 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4 H -imidazo[5,1- c ][1,4]benzoxazine-3-carboxamide (GSK588045) by Bromidge, Steven M., Arban, Roberto, Bertani, Barbara, Bison, Silvia, Borriello, Manuela, Cavanni, Paolo, Dal Forno, Giovanna, Di-Fabio, Romano, Donati, Daniele, Fontana, Stefano, Gianotti, Massimo, Gordon, Laurie J., Granci, Enrica, Leslie, Colin P., Moccia, Luca, Pasquarello, Alessandra, Sartori, Ilaria, Sava, Anna, Watson, Jeannette M., Worby, Angela, Zonzini, Laura, Zucchelli, Valeria

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Design and synthesis of novel tricyclic benzoxazines as potent 5-HT(1A/B/D) receptor antagonists leading to the discovery of 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide (GSK588045) by Bromidge, Steven M, Arban, Roberto, Bertani, Barbara, Bison, Silvia, Borriello, Manuela, Cavanni, Paolo, Dal Forno, Giovanna, Di-Fabio, Romano, Donati, Daniele, Fontana, Stefano, Gianotti, Massimo, Gordon, Laurie J, Granci, Enrica, Leslie, Colin P, Moccia, Luca, Pasquarello, Alessandra, Sartori, Ilaria, Sava, Anna, Watson, Jeannette M, Worby, Angela, Zonzini, Laura, Zucchelli, Valeria

“…Bioisoteric replacement of the metabolically labile N-methyl amide group of a series of benzoxazinones with small heterocyclic rings has led to novel series of…”
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