Search Results - "Mocavini, Ivano"
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Engaging chromatin: PRC2 structure meets function
Published in British journal of cancer (04-02-2020)“…Polycomb repressive complex 2 (PRC2) is a key epigenetic multiprotein complex involved in the regulation of gene expression in metazoans. PRC2 is formed by a…”
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Polycomb complexes in normal and malignant hematopoiesis
Published in The Journal of cell biology (07-01-2019)“…Epigenetic mechanisms are crucial for sustaining cell type-specific transcription programs. Among the distinct factors, Polycomb group (PcG) proteins are major…”
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JARID1B expression and its function in DNA damage repair are tightly regulated by miRNAs in breast cancer
Published in Cancer science (01-04-2019)“…JARID1B/KDM5B histone demethylase's mRNA is markedly overexpressed in breast cancer tissues and cell lines and the protein has been shown to have a prominent…”
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RNA closing the Polycomb circle
Published in Nature genetics (01-09-2020)“…Binding of RNA to the gene expression regulator Polycomb repressive complex 2 (PRC2) has been proposed to antagonize PRC2’s chromatin recruitment. A new study…”
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Polycomb function in early mouse development
Published in Cell death and differentiation (12-07-2024)“…Epigenetic factors are crucial for ensuring proper chromatin dynamics during the initial stages of embryo development. Among these factors, the Polycomb group…”
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Alternative splicing decouples local from global PRC2 activity
Published in Molecular cell (21-03-2024)“…The Polycomb repressive complex 2 (PRC2) mediates epigenetic maintenance of gene silencing in eukaryotes via methylation of histone H3 at lysine 27 (H3K27)…”
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Thymine DNA glycosylase regulates cell-cycle-driven p53 transcriptional control in pluripotent cells
Published in Molecular cell (03-08-2023)“…Cell cycle progression is linked to transcriptome dynamics and variations in the response of pluripotent cells to differentiation cues, mostly through unknown…”
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JARID 1B expression and its function in DNA damage repair are tightly regulated by mi RNA s in breast cancer
Published in Cancer science (01-04-2019)“…JARID 1B/ KDM 5B histone demethylase's mRNA is markedly overexpressed in breast cancer tissues and cell lines and the protein has been shown to have a…”
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