Appraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations

Appraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations

The present study investigates the wound healing potential of three chitosan-based topical preparations loaded with either tea tree essential oil, rosemary essential oil or a mixture of both oils in vivo. Essential oils of M. alternifolia and R. officinalis were analyzed using GC/MS. Essential oil-l...

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Bibliographic Details
Published in:PloS one Vol. 14; no. 9; p. e0219561
Main Authors: Labib, Rola M, Ayoub, Iriny M, Michel, Haidy E, Mehanny, Mina, Kamil, Verena, Hany, Meryl, Magdy, Mirette, Moataz, Aya, Maged, Boula, Mohamed, Ahmed
Format: Journal Article
Language:English
Published: United States Public Library of Science 16-09-2019
Public Library of Science (PLoS)
Subjects:
Acids
Analysis
Animals
Antioxidants
Antioxidants (Nutrients)
Biology and Life Sciences
Chemical composition
Chitosan
Composition
Contraction
Dermatology
Diabetes
Essences and essential oils
Essential oils
Follicles
Food
Gas Chromatography-Mass Spectrometry
Glutathione - metabolism
Health aspects
Infections
Lipid Metabolism - drug effects
Lipid Peroxidation - drug effects
Male
Medicine and Health Sciences
Melaleuca alternifolia
Monoterpenes
Oils & fats
Oils, Volatile - administration & dosage
Oils, Volatile - chemistry
Oxygenation
Pharmacy
Polyvinyl alcohol
Rats
Reactive Oxygen Species - metabolism
Rosemary
Rosmarinus officinalis
Skin - drug effects
Skin - metabolism
Skin - pathology
Tea tree oil
Tea Tree Oil - administration & dosage
Tea Tree Oil - chemistry
Topical application
Wound care
Wound healing
Wound Healing - drug effects
Egypt
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Summary:The present study investigates the wound healing potential of three chitosan-based topical preparations loaded with either tea tree essential oil, rosemary essential oil or a mixture of both oils in vivo. Essential oils of M. alternifolia and R. officinalis were analyzed using GC/MS. Essential oil-loaded chitosan topical preparations were formulated. Wound healing potential was evaluated in vivo using an excision wound model in rats. GC/MS analysis of M. alternifolia and R. officinalis essential oils revealed richness in oxygenated monoterpenes, representing 51.06% and 69.61% of the total oil composition, respectively. Topical application of chitosan-based formulation loaded with a mixture of tea tree and rosemary oils resulted in a significant increase in wound contraction percentage compared to either group treated with individual essential oils and the untreated group. Histopathological examination revealed that topical application of tea tree and rosemary oil combination demonstrated complete re-epithelialization associated with activated hair follicles. The high percentage of oxygenated monoterpenes in both essential oils play an important role in the antioxidant and wound healing potential observed herein. Incorporation of tea tree and rosemary essential oils in chitosan-based preparations in appropriate combination could efficiently promote different stages of wound healing.
Bibliography:Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0219561