Search Results - "Moake, Joel"

Factor VIII Is Synthesized in Human Endothelial Cells, Packaged in Weibel-Palade Bodies and Secreted Bound to ULVWF Strings by Turner, Nancy A, Moake, Joel L

“…The cellular synthesis site and ensuing storage location for human factor VIII (FVIII), the coagulation protein deficient in hemophilia A, has been elusive…”
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Thrombotic Microangiopathies by Moake, Joel L

“…This article reviews the substantial progress made in understanding the thrombotic microangiopathies. The mechanisms of both thrombotic thrombocytopenic…”
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Acquired von Willebrand syndrome associated with left ventricular assist device by Nascimbene, Angelo, Neelamegham, Sriram, Frazier, O.H., Moake, Joel L., Dong, Jing-fei

“…Left ventricular assist devices (LVAD) provide cardiac support for patients with end-stage heart disease as either bridge or destination therapy, and have…”
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Thrombotic thrombocytopenic purpura by Kremer Hovinga, Johanna A., Coppo, Paul, Lämmle, Bernhard, Moake, Joel L., Miyata, Toshiyuki, Vanhoorelbeke, Karen

“…Thrombotic thrombocytopenic purpura (TTP; also known as Moschcowitz disease) is characterized by the concomitant occurrence of often severe thrombocytopenia,…”
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Heat-inactivated Factor B inhibits alternative pathway fluid-phase activation and convertase formation on endothelial cell-secreted ultra-large von Willebrand factor strings by Turner, Nancy A., Moake, Joel L.

“…Defective regulation of the alternative complement pathway (AP) causes excessive activation and promotes the inflammation and renal injury observed in atypical…”
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A new therapeutic strategy for atypical HUS by Moake, Joel L.

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Brain microvascular endothelial cells exhibit lower activation of the alternative complement pathway than glomerular microvascular endothelial cells by Sartain, Sarah E., Turner, Nancy A., Moake, Joel L.

“…Atypical hemolytic uremic syndrome (aHUS) and bone marrow transplantation-associated thrombotic microangiopathy (TA-TMA) are associated with excessive…”
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Assembly and activation of alternative complement components on endothelial cell-anchored ultra-large von Willebrand factor links complement and hemostasis-thrombosis by Turner, Nancy A, Moake, Joel

“…Vascular endothelial cells (ECs) express and release protein components of the complement pathways, as well as secreting and anchoring ultra-large von…”
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Production and control of coagulation proteins for factor X activation in human endothelial cells and fibroblasts by Cohen, Clay T., Turner, Nancy A., Moake, Joel L.

“…Human endothelial cells (ECs) synthesize, store, and secrete von Willebrand factor multimeric strings and coagulation factor (F) VIII. It is not currently…”
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TNF Regulates Essential Alternative Complement Pathway Components and Impairs Activation of Protein C in Human Glomerular Endothelial Cells by Sartain, Sarah E, Turner, Nancy A, Moake, Joel L

“…Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy with severe renal injury secondary to an overactive alternative complement pathway…”
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Human endothelial cells and fibroblasts express and produce the coagulation proteins necessary for thrombin generation by Cohen, Clay T., Turner, Nancy A., Moake, Joel L.

“…In a previous study, we reported that human endothelial cells (ECs) express and produce their own coagulation factors (F) that can activate cell surface FX…”
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N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice by Chen, Junmei, Reheman, Adili, Gushiken, Francisca C, Nolasco, Leticia, Fu, Xiaoyun, Moake, Joel L, Ni, Heyu, López, José A

“…Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease characterized by systemic microvascular thrombosis caused by adhesion of platelets to…”
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Thrombotic thrombocytopenia purpura (TTP) and other thrombotic microangiopathies by Moake, Joel, MD

“…Thrombotoic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy characterised by systemic platelet aggregation, organ ischaemia, profound…”
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Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage by Turner, Nancy A., Nolasco, Leticia, Ruggeri, Zaverio M., Moake, Joel L.

“…Human umbilical vein endothelial cell (HUVEC)–released ADAMTS-13 (a disintegrin and metalloprotease with thrombospondin repeats) and HUVEC-secreted von…”
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Laminin Peptide-Immobilized Hydrogels Modulate Valve Endothelial Cell Hemostatic Regulation by Balaoing, Liezl Rae, Post, Allison Davis, Lin, Adam Yuh, Tseng, Hubert, Moake, Joel L, Grande-Allen, K Jane

“…Valve endothelial cells (VEC) have unique phenotypic responses relative to other types of vascular endothelial cells and have highly sensitive hemostatic…”
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Effects of inflammatory cytokines on the release and cleavage of the endothelial cell–derived ultralarge von Willebrand factor multimers under flow by Bernardo, Aubrey, Ball, Chalmette, Nolasco, Leticia, Moake, Joel F., Dong, Jing-fei

“…ADAMTS13 cleaves ultralarge and hyperreactive von Willebrand factor (ULVWF) freshly released from activated endothelial cells to smaller and less active forms…”
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Thrombotic Microangiopathies: Multimers, Metalloprotease, and Beyond by Moake, Joel

“…The pathophysiology of various types of thrombotic microangiopathies is coming progressively into focus. Therapeutic advances are likely to follow at a…”
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Treatment of refractory thrombotic thrombocytopenic purpura with N-acetylcysteine: a case report by Li, Gloria W., Rambally, Siayareh, Kamboj, Jasmine, Reilly, Sean, Moake, Joel L., Udden, Mark M., Mims, Martha P.

“…Background Thrombotic thrombocytopenic purpura (TTP) is a life‐threatening disease resulting in systemic microvascular thrombosis. The disease is caused by…”
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Regulatory components of the alternative complement pathway in endothelial cell cytoplasm, factor H and factor I, are not packaged in Weibel-Palade bodies by Turner, Nancy A, Sartain, Sarah E, Hui, Shiu-Ki, Moake, Joel L

“…It was recently reported that factor H, a regulatory component of the alternative complement pathway, is stored with von Willebrand factor (VWF) in the…”
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Correlating Conformational Dynamics with the Von Willebrand Factor Reductase Activity of Factor H Using Single Molecule Force Measurements by Wijeratne, Sithara S, Nolasco, Leticia, Li, Jingqiang, Jiang, Kevin, Moake, Joel L, Kiang, Ching-Hwa

“…Activation of proteins often involves conformational transitions, and these switches are often difficult to characterize in multidomain proteins. Full-length…”
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