Search Results - "Mörtl, Mario"

The E. coli effector protein NleF is a caspase inhibitor by Blasche, Sonja, Mörtl, Mario, Steuber, Holger, Siszler, Gabriella, Nisa, Shahista, Schwarz, Frank, Lavrik, Inna, Gronewold, Thomas M A, Maskos, Klaus, Donnenberg, Michael S, Ullmann, Dirk, Uetz, Peter, Kögl, Manfred

“…Enterohemorrhagic and enteropathogenic E. coli (EHEC and EPEC) can cause severe and potentially life-threatening infections. Their pathogenicity is mediated by…”
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The Rational Design of Selective Benzoxazepin Inhibitors of the α‑Isoform of Phosphoinositide 3‑Kinase Culminating in the Identification of (S)‑2-((2-(1-Isopropyl‑1H‑1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2‑d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326) by Heffron, Timothy P, Heald, Robert A, Ndubaku, Chudi, Wei, BinQing, Augistin, Martin, Do, Steven, Edgar, Kyle, Eigenbrot, Charles, Friedman, Lori, Gancia, Emanuela, Jackson, Philip S, Jones, Graham, Kolesnikov, Aleksander, Lee, Leslie B, Lesnick, John D, Lewis, Cristina, McLean, Neville, Mörtl, Mario, Nonomiya, Jim, Pang, Jodie, Price, Steve, Prior, Wei Wei, Salphati, Laurent, Sideris, Steve, Staben, Steven T, Steinbacher, Stefan, Tsui, Vickie, Wallin, Jeffrey, Sampath, Deepak, Olivero, Alan G

“…Inhibitors of the class I phosphoinositide 3-kinase (PI3K) isoform PI3Kα have received substantial attention for their potential use in cancer therapy. Despite…”
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The crystal structure of the ligand‐binding module of human TAG‐1 suggests a new mode of homophilic interaction by Mörtl, Mario, Sonderegger, Peter, Diederichs, Kay, Welte, Wolfram

“…Human TAG‐1 is a neural cell adhesion molecule that is crucial for the development of the nervous system during embryogenesis. It consists of six…”
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Structure-Function Correlation in Glycine Oxidase from Bacillus subtilis by Mörtl, Mario, Diederichs, Kay, Welte, Wolfram, Molla, Gianluca, Motteran, Laura, Andriolo, Gabriella, Pilone, Mirella S, Pollegioni, Loredano

“…Structure-function relationships of the flavoprotein glycine oxidase (GO), which was recently proposed as the first enzyme in the biosynthesis of thiamine in…”
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Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers by Gerritz, Samuel W, Cianci, Christopher, Kim, Sean, Pearce, Bradley C, Deminie, Carol, Discotto, Linda, McAuliffe, Brian, Minassian, Beatrice F, Shi, Shuhao, Zhu, Shirong, Zhai, Weixu, Pendri, Annapurna, Li, Guo, Poss, Michael A, Edavettal, Suzanne, McDonnell, Patricia A, Lewis, Hal A, Maskos, Klaus, Mörtl, Mario, Kiefersauer, Reiner, Steinbacher, Stefan, Baldwin, Eric T, Metzler, William, Bryson, James, Healy, Matthew D, Philip, Thomas, Zoeckler, Mary, Schartman, Richard, Sinz, Michael, Leyva-Grado, Victor H, Hoffmann, Hans-Heinrich, Langley, David R, Meanwell, Nicholas A, Krystal, Mark

“…Influenza nucleoprotein (NP) plays multiple roles in the virus life cycle, including an essential function in viral replication as an integral component of the…”
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Discovery and optimization of a novel series of potent mutant B-Raf(V600E) selective kinase inhibitors by Vasbinder, Melissa M, Aquila, Brian, Augustin, Martin, Chen, Huawei, Cheung, Tony, Cook, Donald, Drew, Lisa, Fauber, Benjamin P, Glossop, Steve, Grondine, Michael, Hennessy, Edward, Johannes, Jeffrey, Lee, Stephen, Lyne, Paul, Mörtl, Mario, Omer, Charles, Palakurthi, Sangeetha, Pontz, Timothy, Read, Jon, Sha, Li, Shen, Minhui, Steinbacher, Stefan, Wang, Haixia, Wu, Allan, Ye, Minwei

“…B-Raf represents an attractive target for anticancer therapy and the development of small molecule B-Raf inhibitors has delivered new therapies for metastatic…”
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Discovery and Optimization of a Novel Series of Potent Mutant B-Raf V600E Selective Kinase Inhibitors by Vasbinder, Melissa M., Aquila, Brian, Augustin, Martin, Chen, Huawei, Cheung, Tony, Cook, Donald, Drew, Lisa, Fauber, Benjamin P., Glossop, Steve, Grondine, Michael, Hennessy, Edward, Johannes, Jeffrey, Lee, Stephen, Lyne, Paul, Mörtl, Mario, Omer, Charles, Palakurthi, Sangeetha, Pontz, Timothy, Read, Jon, Sha, Li, Shen, Minhui, Steinbacher, Stefan, Wang, Haixia, Wu, Allan, Ye, Minwei

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Discovery and Optimization of a Novel Series of Potent Mutant B‑RafV600E Selective Kinase Inhibitors by Vasbinder, Melissa M, Aquila, Brian, Augustin, Martin, Chen, Huawei, Cheung, Tony, Cook, Donald, Drew, Lisa, Fauber, Benjamin P, Glossop, Steve, Grondine, Michael, Hennessy, Edward, Johannes, Jeffrey, Lee, Stephen, Lyne, Paul, Mörtl, Mario, Omer, Charles, Palakurthi, Sangeetha, Pontz, Timothy, Read, Jon, Sha, Li, Shen, Minhui, Steinbacher, Stefan, Wang, Haixia, Wu, Allan, Ye, Minwei

“…B-Raf represents an attractive target for anticancer therapy and the development of small molecule B-Raf inhibitors has delivered new therapies for metastatic…”
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The E. coli Effector Protein NleF Is a Caspase Inhibitor. e58937 by Blasche, Sonja, Mortl, Mario, Steuber, Holger, Siszler, Gabriella, Nisa, Shahista, Schwarz, Frank, Lavrik, Inna, Gronewold, Thomas MA, Maskos, Klaus, Donnenberg, Michael S

“…Enterohemorrhagic and enteropathogenic E. coli (EHEC and EPEC) can cause severe and potentially life-threatening infections. Their pathogenicity is mediated by…”
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