Search Results - "Möhler, Hanns"

The GABA system in anxiety and depression and its therapeutic potential by Möhler, Hanns

“…In the regulation of behavior, the role of GABA neurons has been extensively studied in the circuit of fear, where GABA interneurons play key parts in the…”
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The legacy of the benzodiazepine receptor: from flumazenil to enhancing cognition in Down syndrome and social interaction in autism by Möhler, Hanns

“…The study of the psychopharmacology of benzodiazepines continues to provide new insights into diverse brain functions related to vigilance, anxiety, mood,…”
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Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics by RUDOLPH, Uwe, MOHLER, Hanns

“…GABAA receptors are molecular substrates for the regulation of vigilance, anxiety, muscle tension, epileptogenic activity, and memory functions, and the…”
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Role of GABAA receptors in cognition by Möhler, Hanns

“…Complex brains have developed specialized mechanisms for the grouping of principal cells into temporal coalitions of local or distant networks: the inhibitory…”
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Impact on GABA systems in monogenetic developmental CNS disorders: Clues to symptomatic treatment by Benke, Dietmar, Möhler, Hanns

“…Animal studies of several single-gene disorders demonstrate that reversing the molecular signaling deficits can result in substantial symptomatic improvements…”
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Brexanolone, a neurosteroid antidepressant, vindicates the GABAergic deficit hypothesis of depression and may foster resilience [version 1; peer review: 4 approved] by Lüscher, Bernhard, Möhler, Hanns

“…The GABAergic deficit hypothesis of depression states that a deficit of GABAergic transmission in defined neural circuits is causal for depression. Conversely,…”
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Disinhibition, an emerging pharmacology of learning and memory [version 1; peer review: 3 approved] by Möhler, Hanns, Rudolph, Uwe

“…Learning and memory are dependent on interactive excitatory and inhibitory mechanisms. In this review, we discuss a mechanism called disinhibition, which is…”
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GABAA Receptors in Central Nervous System Disease: Anxiety, Epilepsy, and Insomnia by Mohler, Hanns

“…Brain function is based on an exquisite balance between excitatory and inhibitory neurotransmission. GABAergic neurons provide the major inhibitory control. By…”
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Reversal of pathological pain through specific spinal GABAA receptor subtypes by Knabl, Julia, Witschi, Robert, Hösl, Katharina, Reinold, Heiko, Zeilhofer, Ulrike B., Ahmadi, Seifollah, Brockhaus, Johannes, Sergejeva, Marina, Hess, Andreas, Brune, Kay, Fritschy, Jean-Marc, Rudolph, Uwe, Möhler, Hanns, Zeilhofer, Hanns Ulrich

“…A new target for analgesia The chronic pain that accompanies inflammatory disease and nerve injury is often resistant to conventional analgesics, hence the…”
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Endogenous Benzodiazepine Site Peptide Ligands Operating Bidirectionally In Vivo in Neurogenesis and Thalamic Oscillations by Mohler, Hanns

“…By binding to the benzodiazepine site, diazepam binding inhibitor (DBI) is associated with negative allosteric modulation (NAM) of GABA A receptors (Costa and…”
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GABAergic analgesia: new insights from mutant mice and subtype-selective agonists by Zeilhofer, Hanns Ulrich, Möhler, Hanns, Di Lio, Alessandra

“…γ-Aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the brain where it regulates many physiological functions including sleep,…”
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GABAA receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts by Benke, Dietmar, Barberis, Andrea, Kopp, Sascha, Altmann, Karl-Heinz, Schubiger, Monika, Vogt, Kaspar E., Rudolph, Uwe, Möhler, Hanns

“…Valerian extracts have been used for centuries to alleviate restlessness and anxiety albeit with unknown mechanism of action in vivo. We now describe a…”
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Specific GABAA circuits for visual cortical plasticity by FAGIOLINI, Michela, FRITSCHY, Jean-Marc, LÖW, Karin, MÖHLER, Hanns, RUDOLPH, Uwe, HENSCH, Takao K

“…Weak inhibition within visual cortex early in life prevents experience-dependent plasticity. Loss of responsiveness to an eye deprived of vision can be…”
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Molecular and Neuronal Substrate for the Selective Attenuation of Anxiety by Löw, Karin, Crestani, Florence, Keist, Ruth, Benke, Dietmar, Brünig, Ina, Benson, Jack A., Fritschy, Jean-Marc, Rülicke, Thomas, Bluethmann, Horst, Möhler, Hanns, Rudolph, Uwe

“…Benzodiazepine tranquilizers are used in the treatment of anxiety disorders. To identify the molecular and neuronal target mediating the anxiolytic action of…”
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Redox-directed cancer therapeutics: Taurolidine and Piperlongumine as broadly effective antineoplastic agents (Review) by MÖHLER, HANS, PFIRMAN, ROLF W, FREI, KARL

“…Targeting the oxygen stress response pathway is considered a promising strategy to exert antineoplastic activity in a broad spectrum of tumor types. Supporting…”
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Glycine transporter 1 as a potential therapeutic target for schizophrenia-related symptoms: Evidence from genetically modified mouse models and pharmacological inhibition by Möhler, Hanns, Boison, Detlev, Singer, Philipp, Feldon, Joram, Pauly-Evers, Meike, Yee, Benjamin K.

“…Inhibiting glycine transporters, GlyT1, but not GlyT2, enhances NMDA-receptor-mediated neurotransmission, thus offers an effective strategy against…”
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GABAA receptor subtypes: Therapeutic potential in Down syndrome, affective disorders, schizophrenia, and autism by Rudolph, Uwe, Möhler, Hanns

“…The γ-aminobutyric acid (GABA) system plays a pivotal role in orchestrating the synchronicity of local networks and the functional coupling of different brain…”
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Mechanism of action of the hypnotic zolpidem in vivo by Crestani, Florence, Martin, James R, Möhler, Hanns, Rudolph, Uwe

“…Zolpidem is a widely used hypnotic agent acting at the GABAA receptor benzodiazepine site. On recombinant receptors, zolpidem displays a high affinity to…”
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Examining the sex- and circadian dependency of a learning phenotype in mice with glycine transporter 1 deletion in two Pavlovian conditioning paradigms by Dubroqua, Sylvain, Boison, Detlev, Feldon, Joram, Möhler, Hanns, Yee, Benjamin K.

“…► Forebrain neuronal deletion of glycine transporter 1 enhances Pavlovian conditioning. ► Its robust expression across sexes, circadian phases and paradigms is…”
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Grafts of Adenosine-Releasing Cells Suppress Seizures in Kindling Epilepsy by Huber, Alexander, Padrun, Vivianne, Déglon, Nicole, Aebischer, Patrick, Möhler, Hanns, Boison, Detlev

“…Adenosine is an inhibitor of neuronal activity in the brain. The local release of adenosine from grafted cells was evaluated as an ex vivo gene therapy…”
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