Search Results - "Mo, Jiezhen"
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Detection of Human Urinary 5‑Hydroxymethylcytosine by Stable Isotope Dilution HPLC-MS/MS Analysis
Published in Analytical chemistry (Washington) (03-02-2015)“…The sixth DNA base 5-hydroxymethylcytosine (5hmC) is the major oxidation product of the epigenetic modification 5-methylcytosine (5mC), mediating DNA…”
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Global DNA 5‐Hydroxymethylcytosine and 5‐Formylcytosine Contents Are Decreased in the Early Stage of Hepatocellular Carcinoma
Published in Hepatology (Baltimore, Md.) (01-01-2019)“…Methylation of the fifth position of cytosine (5mC) is an important epigenetic modification of DNA. It has been shown that the oxidized derivatives of 5mC,…”
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Profiling of epigenetic DNA modifications by advanced liquid chromatography-mass spectrometry technologies
Published in TrAC, Trends in analytical chemistry (Regular ed.) (01-01-2019)“…Four DNA bases are essential biochemical elements for coding heritable life blueprint. Meanwhile, organisms utilize modifying enzymes to post chemical groups…”
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Nickel(II) Inhibits Tet-Mediated 5‑Methylcytosine Oxidation by High Affinity Displacement of the Cofactor Iron(II)
Published in ACS chemical biology (16-06-2017)“…Ten-eleven translocation (Tet) family proteins are Fe(II)- and 2-oxoglutarate-dependent dioxygenases that regulate the dynamics of DNA methylation by…”
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Nickel(ii) inhibits the oxidation of DNA 5-methylcytosine in mammalian somatic cells and embryonic stem cells
Published in Metallomics (01-03-2018)“…Nickel is found widely in the environment. It is an essential microelement but also toxic. However, nickel displays only weak genotoxicity and mutagenicity…”
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Author Correction: N6-methyladenine is incorporated into mammalian genome by DNA polymerase
Published in Cell research (01-02-2021)“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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N6-methyladenine is incorporated into mammalian genome by DNA polymerase
Published in Cell research (2021)Get full text
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Protonation-Suppression-Free LC-MS/MS Analysis for Profiling of DNA Cytosine Modifications in Adult Mice
Published in Analytical chemistry (Washington) (02-06-2020)“…DNA cytosine modifications are important epigenetic marks. To elucidate their roles by a large scale of comparative studies, it is important to quantify the…”
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N 6 -methyladenine is incorporated into mammalian genome by DNA polymerase
Published in Cell research (01-01-2021)Get full text
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Structural insights into molecular mechanism for N6-adenosine methylation by MT-A70 family methyltransferase METTL4
Published in Nature communications (26-09-2022)“…METTL4 belongs to a subclade of MT-A70 family members of methyltransferase (MTase) proteins shown to mediate N 6 -adenosine methylation for both RNA and DNA in…”
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Single-Cell Multi-Omics Analysis Reveals Hematopoiesis of Aberrant Mast Cells in Systemic Mastocytosis
Published in BLOOD (15-11-2022)Get full text
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CRISPR/Cas9-mediated gene disruption determines the roles of MITF and CITED2 in human mast cell differentiation
Published in Blood advances (13-08-2024)Get full text
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Structural insights into molecular mechanism for N 6 -adenosine methylation by MT-A70 family methyltransferase METTL4
Published in Nature communications (26-09-2022)“…METTL4 belongs to a subclade of MT-A70 family members of methyltransferase (MTase) proteins shown to mediate N -adenosine methylation for both RNA and DNA in…”
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Structural insights into molecular mechanism for N 6-adenosine methylation by MT-A70 family methyltransferase METTL4
Published in Nature communications (01-09-2022)“…Here the authors combine functional and structural work to show that METTL4 functions as U2 snRNA m6Am RNA methyltransferase supporting N6-methylation of…”
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Author Correction: N 6 -methyladenine is incorporated into mammalian genome by DNA polymerase
Published in Cell research (01-02-2021)Get full text
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