Search Results - "Mnkugwe, Rajabu Hussein"

Optimal single sampling time-point for monitoring of praziquantel exposure in children by Mnkugwe, Rajabu Hussein, Ngaimisi Kitabi, Eliford, Kinung’hi, Safari, Kamuhabwa, Appolinary A. R., Minzi, Omary Mashiku, Aklillu, Eleni

“…Praziquantel pharmacokinetics studies in schistosomiasis infected children are scarce partly due to the challenges/complexity of intensive blood sampling in…”
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Efficacy and safety of praziquantel and dihydroartemisinin piperaquine combination for treatment and control of intestinal schistosomiasis: A randomized, non-inferiority clinical trial by Mnkugwe, Rajabu Hussein, Minzi, Omary, Kinung'hi, Safari, Kamuhabwa, Appolinary, Aklillu, Eleni

“…Background Despite the reported success in reducing morbidity, praziquantel alone is insufficient for the control and elimination of schistosomiasis, partly…”
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Prevalence and correlates of intestinal schistosomiasis infection among school-aged children in North-Western Tanzania by Mnkugwe, Rajabu Hussein, Minzi, Omary S, Kinung'hi, Safari M, Kamuhabwa, Appolinary A, Aklillu, Eleni

“…Schistosomiasis is a neglected tropical disease that continues to cause morbidity and mortality in Sub Saharan Africa. Due to its endemicity, co-infection with…”
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Effect of pharmacogenetic variations on praziquantel plasma concentration and safety outcomes among school children in Rwanda by Barry, Abbie, Kabatende, Joseph, Telele, Nigus Fikrie, Mnkugwe, Rajabu Hussein, Mugisha, Michael, Ntirenganya, Lazare, Bienvenu, Emile, Aklillu, Eleni

“…School-based mass drug administration (MDA) of Praziquantel (PZQ) is the global intervention strategy for elimination of schistosomiasis. Genetic variations in…”
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CYP2C19 and CYP2J2 genotypes predict praziquantel plasma exposure among Ethiopian school-aged children by Gebreyesus, Tigist Dires, Makonnen, Eyasu, Telele, Nigus Fikrie, Barry, Abbie, Mnkugwe, Rajabu Hussein, Gerba, Heran, Dahl, Marja-Liisa, Aklillu, Eleni

“…Metabolism of praziquantel (PZQ), a racemic mixture and the only drug approved to treat S. mansoni infection, is mediated by genetically polymorphic enzymes…”
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Effect of Pharmacogenetics Variations on Praziquantel Plasma Concentrations and Schistosomiasis Treatment Outcomes Among Infected School-Aged Children in Tanzania by Mnkugwe, Rajabu Hussein, Minzi, Omary, Kinung’hi, Safari, Kamuhabwa, Appolinary, Aklillu, Eleni

“…Studies on pharmacogenetics of praziquantel (PZQ) and its relevance on plasma drug concentrations and schistosomiasis treatment outcomes are lacking. We…”
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Incidence and determinants of adverse events in individuals with HIV commencing Dolutegravir-based antiretroviral therapy in mainland Tanzania by Fimbo, Adam, Mwalwisi, Yonah H., Mwamwitwa, Kissa, Matiko, Damas, Mfinanga, Elirehema, Lyimo, Johnson, Sabasaba, Amon, Missago, Seth, Bukundi, Elias, Gotora, Goodluck, Respick, Dorice, Nkayamba, Alex, Masunga, Emmanuel, Mnkugwe, Rajabu Hussein, Kunambi, Peter P., Munishi, Castory, Musanhu, Christine Chiedza, Minzi, Omary M. S., Mlugu, Eulambius M.

“…Tanzania adopted a Dolutegravir (DTG)-based regimen as first-line treatment in 2019 following the World Health Organization recommendation. Data on the DTG…”
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Effect of Dihydroartemisinin-Piperaquine on the Pharmacokinetics of Praziquantel for Treatment of Schistosoma mansoni Infection by Minzi, Omary Mashiku, Mnkugwe, Rajabu Hussein, Ngaimisi, Eliford, Kinung'hi, Safari, Hansson, Anna, Pohanka, Anton, Kamuhabwa, Appolinary, Aklillu, Eleni

“…Praziquantel (PZQ) and dihydroartemisinin-piperaquine (DHP) combination recently showed superior effectiveness than PZQ alone to treat intestinal…”
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Efficacy of ivermectin and albendazole combination in suppressing transmission of lymphatic filariasis following mass administration in Tanzania: a prospective cohort study by Fimbo, Adam M, Mnkugwe, Rajabu Hussein, Mlugu, Eulambius Mathias, Kunambi, Peter P, Malishee, Alpha, Minzi, Omary M S, Kamuhabwa, Appolinary A R, Aklillu, Eleni

“…Preventive chemotherapy with ivermectin and albendazole (IA) in mass drug administration (MDA) programs for all at-risk populations is the core public health…”
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Population pharmacokinetics of ivermectin after mass drug administration in lymphatic filariasis endemic communities of Tanzania by Fimbo, Adam M., Mlugu, Eulambius M., Kitabi, Eliford Ngaimisi, Kulwa, Gerald S., Iwodyah, Mohammed A., Mnkugwe, Rajabu Hussein, Kunambi, Peter P., Malishee, Alpha, Kamuhabwa, Appolinary A. R., Minzi, Omary M., Aklillu, Eleni

“…Ivermectin (IVM) is a drug of choice used with albendazole for mass drug administration (MDA) to halt transmission of lymphatic filariasis. We investigated IVM…”
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Efficacy and Safety of Praziquantel for Treatment of Schistosoma mansoni Infection among School Children in Tanzania by Mnkugwe, Rajabu Hussein, Minzi, Omary S, Kinung'hi, Safari M, Kamuhabwa, Appolinary A, Aklillu, Eleni

“…Single-dose targeted praziquantel preventive chemotherapy is the WHO-recommended intervention for schistosomiasis control in endemic countries. The objective…”
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Gentamicin concentration and acute kidney injury in term neonates treated for neonatal sepsis with gentamicin and ampicillin-cloxacillin combination by James, Masanyiwa Ernest, Naburi, Helga, Mugusi, Sabina, Kunambi, Peter P, Mwakyandile, Tosi, Mnkugwe, Rajabu Hussein, Khalfan, Mohamed Ally, Moshi, Mainen J, Minzi, Omary M, Sasi, Philip

“…Gentamicin is widely used to treat neonatal infections caused by both Gram-negative and Gram-positive bacteria, and the WHO recommends its use while monitoring…”
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CYP2B6 and ABCB1 genotypes predict methadone plasma exposure among patients on maintenance therapy against opioid addictions in Tanzania by Mugusi, Sabina, Mnkugwe, Rajabu Hussein, Sanga, Anna A., Salahuddin, Azreen, Barclay, Victoria, Shayo, Grace, Dahl, Marja‐Liisa, Aklillu, Eleni

“…Aims Methadone maintenance therapy (MMT) exhibits significant variability in pharmacokinetics and clinical response, partly due to genetic variations. However,…”
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Novel Combination Chemotherapy for Treatment and Control of Schistosomiasis Among School Children by Mnkugwe, Rajabu Hussein

“…Despite reported success in reducing severe disease-associated morbidities in endemic countries, praziquantel (PZQ) alone has failed to control and eliminate…”
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