Search Results - "Mnich, Stephen J."

Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor by Mbalaviele, Gabriel, Pauley, Adele M., Shaffer, Alexander F., Zweifel, Ben S., Mathialagan, Sumathy, Mnich, Stephen J., Nemirovskiy, Olga V., Carter, Jeff, Gierse, James K., Wang, Jane L., Vazquez, Michael L., Moore, William M., Masferrer, Jaime L.

“…Inflammation-induced microsomal prostaglandin E synthase-1 (mPGES-1) is the terminal enzyme that synthesizes prostaglandin E 2 (PGE 2) downstream of…”
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Synthesis, Crystal Structure, and Activity of Pyrazole-Based Inhibitors of p38 Kinase by Graneto, Matthew J, Kurumbail, Ravi G, Vazquez, Michael L, Shieh, Huey-Sheng, Pawlitz, Jennifer L, Williams, Jennifer M, Stallings, William C, Geng, Lifeng, Naraian, Ashok S, Koszyk, Francis J, Stealey, Michael A, Xu, Xiangdong D, Weier, Richard M, Hanson, Gunnar J, Mourey, Robert J, Compton, Robert P, Mnich, Stephen J, Anderson, Gary D, Monahan, Joseph B, Devraj, Rajesh

“…A series of pyrazole inhibitors of p38 mitogen-activated protein (MAP) kinase were designed using a binding model based on the crystal structure of 1 (SC-102)…”
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Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis by Mnich, Stephen J., Blanner, Patrick M., Hu, Liangbiao G., Shaffer, Alexander F., Happa, Fernando A., O'Neil, Shawn, Ukairo, Okechukwu, Weiss, Dave, Welsh, Eric, Storer, Chad, Mbalaviele, Gabriel, Ichijo, Hidenori, Monahan, Joseph B., Hardy, Medora M., Eda, Hiroyuki

“…In this report, we show that apoptosis signal-regulating kinase 1 −/− (ASK1 KO) mice were resistant to inflammatory arthritis induced in the K/BxN serum…”
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Plasma 3-nitrotyrosine is a biomarker in animal models of arthritis: Pharmacological dissection of iNOS’ role in disease by Nemirovskiy, Olga V., Radabaugh, Melissa R., Aggarwal, Poonam, Funckes-Shippy, Christie L., Mnich, Stephen J., Meyer, Debra M., Sunyer, Teresa, Rodney Mathews, W., Misko, Thomas P.

“…The contribution of inducible nitric oxide synthase (iNOS) to oxidative/nitrative stress is well-documented in inflammation, but difficult to quantify. Using a…”
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Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals by Wang, Chun, Hockerman, Susan, Jacobsen, E Jon, Alippe, Yael, Selness, Shaun R, Hope, Heidi R, Hirsch, Jeffrey L, Mnich, Stephen J, Saabye, Matthew J, Hood, William F, Bonar, Sheri L, Abu-Amer, Yousef, Haimovich, Ariela, Hoffman, Hal M, Monahan, Joseph B, Mbalaviele, Gabriel

“…p38α activation of multiple effectors may underlie the failure of global p38α inhibitors in clinical trials. A unique inhibitor (CDD-450) was developed that…”
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A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation by Mourey, Robert J, Burnette, Barry L, Brustkern, Sarah J, Daniels, J Scott, Hirsch, Jeffrey L, Hood, William F, Meyers, Marvin J, Mnich, Stephen J, Pierce, Betsy S, Saabye, Matthew J, Schindler, John F, South, Sarah A, Webb, Elizabeth G, Zhang, Jian, Anderson, David R

“…Activation of the p38 kinase pathway in immune cells leads to the transcriptional and translational regulation of proinflammatory cytokines. Mitogen-activated…”
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Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/B×N serum-induced arthritis by MNICH, Stephen J, BLANNER, Patrick M, MBALAVIELE, Gabriel, ICHIJO, Hidenori, MONAHAN, Joseph B, HARDY, Medora M, EDA, Hiroyuki, HU, Liangbiao G, SHAFFER, Alexander F, HAPPA, Fernando A, O'NEIL, Shawn, UKAIRO, Okechukwu, WEISS, Dave, WELSH, Eric, STORER, Chad

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Anti-inflammatory properties of CB1-receptor antagonist involves beta2 adrenoceptors by Mnich, Stephen J, Hiebsch, Ronald R, Huff, Rita M, Muthian, Shanmugam

“…Antagonists of the cannabinoid receptor 1 (CB1) impart anti-inflammatory activity even though, paradoxically, CB2 receptors are more predominant on cells of…”
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Characterization of a monoclonal antibody that neutralizes the activity of prostaglandin E2 by Mnich, SJ, Veenhuizen, AW, Monahan, JB, Sheehan, KC, Lynch, KR, Isakson, PC, Portanova, JP

“…We describe the generation of an IgG1 mAb, 2B5, that neutralizes the biologic activity of PGE2 in vitro and in vivo. The Ab was derived from a BALB/c mouse…”
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