Search Results - "Mncube, Zenele"

Compensatory Mutation Partially Restores Fitness and Delays Reversion of Escape Mutation within the Immunodominant HLA-B5703-Restricted Gag Epitope in Chronic Human Immunodeficiency Virus Type 1 Infection by CRAWFORD, Hayley, PRADO, Julia G, MULLINS, James I, KASLOW, Richard, GOEPFERT, Paul, ALLEN, Susan, HUNTER, Eric, MULENGA, Joseph, KIEPIELA, Photini, WALKER, Bruce D, GOULDER, Philip J. R, LESLIE, Alasdair, HUE, Stéphane, HONEYBORNE, Isobella, REDDY, Sharon, VAN DER STOK, Mary, MNCUBE, Zenele, BRANDER, Christian, ROUSSEAU, Christine

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Gag-Protease-Mediated Replication Capacity in HIV-1 Subtype C Chronic Infection: Associations with HLA Type and Clinical Parameters by WRIGHT, Jaclyn K, BRUMME, Zabrina L, VAN DER STOK, Mary, MNCUBE, Zenele, BISHOP, Karen, GOULDER, Philip J. R, WALKER, Bruce D, BROCKMAN, Mark A, NDUNG'U, Thumbi, CARLSON, Jonathan M, HECKERMAN, David, KADIE, Carl M, BRUMME, Chanson J, BINGXIA WANG, LOSINA, Elena, MIURA, Toshiyuki, CHONCO, Fundisiwe

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High frequency of transmitted HIV-1 Gag HLA class I-driven immune escape variants but minimal immune selection over the first year of clade C infection by Gounder, Kamini, Padayachi, Nagavelli, Mann, Jaclyn K, Radebe, Mopo, Mokgoro, Mammekwa, van der Stok, Mary, Mkhize, Lungile, Mncube, Zenele, Jaggernath, Manjeetha, Reddy, Tarylee, Walker, Bruce D, Ndung'u, Thumbi

“…In chronic HIV infection, CD8+ T cell responses to Gag are associated with lower viral loads, but longitudinal studies of HLA-restricted CD8+ T cell-driven…”
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Impact of HLA in Mother and Child on Disease Progression of Pediatric Human Immunodeficiency Virus Type 1 Infection by THOBAKGALE, Christina F, PRENDERGAST, Andrew, CHONCO, Fundi, MPHATSHWE, Wendy, TUDOR-WILLIAMS, Gareth, JEENA, Prakash, BLANCKENBERG, Natasha, DONG, Krista, KIEPIELA, Photini, COOVADIA, Hoosen, NDUNG'U, Thumbi, WALKER, Bruce D, CRAWFORD, Hayle, GOULDER, Philip J. R, MKHWANAZI, Nompumelelo, RAMDUTH, Danni, REDDY, Sharon, MOLINA, Claudia, MNCUBE, Zenele, LESLIE, Alasdair, PRADO, Julia

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Co-operative additive effects between HLA alleles in control of HIV-1 by Matthews, Philippa C, Listgarten, Jennifer, Carlson, Jonathan M, Payne, Rebecca, Huang, Kuan-Hsiang Gary, Frater, John, Goedhals, Dominique, Steyn, Dewald, van Vuuren, Cloete, Paioni, Paolo, Jooste, Pieter, Ogwu, Anthony, Shapiro, Roger, Mncube, Zenele, Ndung'u, Thumbi, Walker, Bruce D, Heckerman, David, Goulder, Philip J R

“…HLA class I genotype is a major determinant of the outcome of HIV infection, and the impact of certain alleles on HIV disease outcome is well studied. Recent…”
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Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection by Ramduth, Danni, Day, Cheryl L, Thobakgale, Christina F, Mkhwanazi, Nompumelelo P, de Pierres, Chantal, Reddy, Sharon, van der Stok, Mary, Mncube, Zenele, Nair, Kriebashne, Moodley, Eshia S, Kaufmann, Daniel E, Streeck, Hendrik, Coovadia, Hoosen M, Kiepiela, Photini, Goulder, Philip J R, Walker, Bruce D

“…A dominance of Gag-specific CD8+ T cell responses is significantly associated with a lower viral load in individuals with chronic, untreated clade C human…”
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Lack of Association between HLA Class II Alleles and In Vitro Replication Capacities of Recombinant Viruses Encoding HIV-1 Subtype C Gag-Protease from Chronically Infected Individuals by WRIGHT, Jaclyn K, BRUMME, Zabrina L, NDUNG'U, Thumbi, JULG, Boris, VAN DER STOK, Mary, MNCUBE, Zenele, XIAOJIANG GAO, CARLSON, Jonathan M, GOULDER, Philip J. R, WALKER, Bruce D, BROCKMAN, Mark A

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Early virological suppression despite high frequency NNRTI resistance following perinatal prophylaxis in HIV-infected African infants by Prendergast, Andrew, Mphatswe, Wendy, Tudor-Williams, Gareth, Blanckenberg, Natasha, Cengimbo, Ayanda, Jeena, Prakash, Rakgotho, Mpho, Pillay, Visva, Thobakgale, Christina, Reddy, Sharon, Mncube, Zenele, Vanderstok, Mary, McCarthy, Noel, Dong, Krista, Coovadia, Hoosen, Morris, Lynn, Walker, Bruce D, Goulder, Philip

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CD8 + T-cell responses to different HIV proteins have discordant associations with viral load by Goulder, Philip, Kiepiela, Photini, Ngumbela, Kholiswa, Thobakgale, Christina, Ramduth, Dhanwanthie, Honeyborne, Isobella, Moodley, Eshia, Reddy, Shabashini, de Pierres, Chantal, Mncube, Zenele, Mkhwanazi, Nompumelelo, Bishop, Karen, van der Stok, Mary, Nair, Kriebashnie, Khan, Nasreen, Crawford, Hayley, Payne, Rebecca, Leslie, Alasdair, Prado, Julia, Prendergast, Andrew, Frater, John, McCarthy, Noel, Brander, Christian, Learn, Gerald H, Nickle, David, Rousseau, Christine, Coovadia, Hoosen, Mullins, James I, Heckerman, David, Walker, Bruce D

“…Selection of T-cell vaccine antigens for chronic persistent viral infections has been largely empirical. To define the relationship, at the population level,…”
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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression by Brown, Julia A, Kiepiela, Photini, Reddy, Sharon, DePierres, Chantal, Coovadia, Hoosen M, Altfeld, Marcus, Kaufmann, Daniel E, Wherry, E. John, Moodley, Eshia S, Goulder, Philip J. R, Freeman, Gordon J, Mackey, Elizabeth W, Leslie, Alasdair J, Eichbaum, Quentin, Zhu, Baogong, Klenerman, Paul, Mncube, Zenele, Walker, Bruce D, Miller, Joseph D, Ahmed, Rafi, Day, Cheryl L, Duraiswamy, Jaikumar

“…Functional impairment of T cells is characteristic of many chronic mouse and human viral infections. The inhibitory receptor programmed death 1 (PD-1; also…”
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HIV-1 evades a Gag mutation that abrogates killer cell immunoglobulin-like receptor binding and disinhibits natural killer cells in infected individuals with KIR2DL2+/HLA-C∗03:04+ genotype by Ziegler, Maja C., Naidoo, Kewreshini, Chapel, Anais, Nkotwana, Sindiswa, Mann, Jaclyn, Mncube, Zenele, Ismael, Nasreen, Goulder, Philip, Ndung’u, Thumbi, Altfeld, Marcus, Thobakgale, Christina F.

“…HIV-1 sequence variations impact binding of inhibitory killer cell immunoglobulin-like receptors (KIRs) to human leukocyte antigen class I (HLA-I) molecules…”
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Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection by Radebe, Mopo, Gounder, Kamini, Mokgoro, Mammekwa, Ndhlovu, Zaza M, Mncube, Zenele, Mkhize, Lungile, van der Stok, Mary, Jaggernath, Manjeetha, Walker, Bruce D, Ndung'u, Thumbi

“…We characterized protein-specific CD8 T-cell immunodominance patterns during the first year of HIV-1 infection, and their impact on viral evolution and immune…”
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HIV–1 evades a gag mutation that abrogates KIR binding and disinhibits NK cells in infected individuals with KIR2DL2+/HLA–C03: 04+ genotype by Ziegler, Maja C, Naidoo, Kewreshini, Chapel, Anais, Nkotwana, Sindiswa, Mann, Jaclyn, Mncube, Zenele, Ismael, Nasreen, Goulder, Philip, Ndung’u, Thumbi, Altfeld, Marcus, Thobakgale, Christina F

“…HIV–1 sequence variations impact binding of inhibitory killer cell immunoglobulin-like receptors (KIRs) to human leucocyte class I (HLA–I) molecules modulating…”
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CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles by Koofhethile, Catherine K, Ndhlovu, Zaza M, Thobakgale-Tshabalala, Christina, Prado, Julia G, Ismail, Nasreen, Mncube, Zenele, Mkhize, Lungile, van der Stok, Mary, Yende, Nonhlanhla, Walker, Bruce D, Goulder, Philip J R, Ndung'u, Thumbi

“…The mechanisms of viral control and loss of viral control in chronically infected individuals with or without protective HLA class I alleles are not fully…”
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Reduced Expression of Siglec-7, NKG2A, and CD57 on Terminally Differentiated CD56 - CD16 + Natural Killer Cell Subset Is Associated with Natural Killer Cell Dysfunction in Chronic HIV-1 Clade C Infection by Zulu, Michael Z, Naidoo, Kewreshini K, Mncube, Zenele, Jaggernath, Manjeetha, Goulder, Philip J R, Ndung'u, Thumbi, Altfeld, Marcus, Thobakgale, Christina F

“…HIV-1 viremia has been shown to induce several phenotypic and functional abnormalities in natural killer (NK) cells. To assess immune defects associated with…”
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Detection of Polyfunctional Mycobacterium tuberculosis–Specific T Cells and Association with Viral Load in HIV-1–Infected Persons by Day, Cheryl L, Mkhwanazi, Nompumelelo, Reddy, Sharon, Mncube, Zenele, van der Stok, Mary, Klenerman, Paul, Walker, Bruce D

“…BackgroundThe human immunodeficiency virus type 1 (HIV-1) epidemic is associated with a significant increase in the incidence of tuberculosis (TB); however,…”
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HIV-1 evades a Gag mutation that abrogates killer cell immunoglobulin-like receptor binding and disinhibits natural killer cells in infected individuals with KIR2DL2+/HLA-C03: 04+ genotype by Ziegler, Maja C, Naidoo, Kewreshini, Chapel, Anais, Nkotwana, Sindiswa, Mann, Jaclyn, Mncube, Zenele, Ismael, Nasreen, Goulder, Philip, Ndung'u, Thumbi, Altfeld, Marcus, Thobakgale, Christina F

“…: HIV-1 sequence variations impact binding of inhibitory killer cell immunoglobulin-like receptors (KIRs) to human leukocyte antigen class I (HLA-I) molecules…”
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Possession of HLA Class II DRB11303 Associates with Reduced Viral Loads in Chronic HIV-1 Clade C and B Infection by Julg, Boris, Moodley, Eshia S., Qi, Ying, Ramduth, Danni, Reddy, Shabashini, Mncube, Zenele, Gao, Xiaojiang, Goulder, Philip J., Detels, Roger, Ndung'u, Thumbi, Walker, Bruce D., Carrington, Mary

“…Background. The HLA class II molecules play a central role in the generation of human immunodeficiency virus (HlV)-specific CD4⁺ T-helper cells, which are…”
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Limited Immunogenicity of HIV CD8⁺ T-Cell Epitopes in Acute Clade C Virus Infection by Radebe, Mopo, Nair, Kriebashnie, Chonco, Fundisiwe, Bishop, Karen, Wright, Jaclyn K., van der Stok, Mary, Basse, Ingrid V., Mncube, Zenele, Altfeld, Marcus, Walker, Bruce D., Ndung'u, Thumbi

“…Background. Human immunodeficiency virus type 1 (HlV-1)-specific CD8⁺ responses contribute to the decline in acute peak viremia following infection. However,…”
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Correction for Thobakgale et al., Impact of HLA in Mother and Child on Disease Progression of Pediatric Human Immunodeficiency Virus Type 1 Infection by Thobakgale, Christina F, Prendergast, Andrew, Crawford, Hayley, Mkhwanazi, Nompumelelo, Ramduth, Danni, Reddy, Sharon, Molina, Claudia, Mncube, Zenele, Leslie, Alasdair, Prado, Julia, Chonco, Fundi, Mphatshwe, Wendy, Tudor-Williams, Gareth, Jeena, Prakash, Blanckenberg, Natasha, Dong, Krista, Kiepiela, Photini, Coovadia, Hoosen, Ndung'u, Thumbi, Walker, Bruce D, Goulder, Philip J R

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