Biochemical changes in tuberculosis

tuberculosis (TB) remains a global health issue with high morbidity and mortality rates especially in the developing countries. It is a multi-organ disease and can influence biochemical changes. This study sought to determine the influence of tuberculosis and its drug treatment on serum biochemical...

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Bibliographic Details
Published in:	The Pan African medical journal Vol. 38; no. 66; p. 66
Main Authors:	Ufoaroh, Chinyelu Uchenna, Onwurah, Chidimma Adaobi, Mbanuzuru, Victor Ahaoma, Mmaju, Chidimma Ifeyinwa, Chukwurah, Shirley Nneka, Umenzekwe, Chukwudi Christian, Aghanya, Iloduba Nnaemeka, Ushie, Simon Nkpeh, Anyabolu, Arthur Ebelenna, Enemuo, Emeka Hyacinth, Anyabolu, Ernest Ndukaife, Ele, Prince Udegbunam
Format:	Journal Article
Language:	English
Published:	Uganda African Field Epidemiology Network 2021 The African Field Epidemiology Network The Pan African Medical Journal
Subjects:	Adolescent Adult Aged Antitubercular Agents - administration & dosage Calcium - blood Cohort Studies Confidence intervals Consent Female Females HIV Human immunodeficiency virus Humans Infections Male Males Middle Aged Nigeria Population Potassium Potassium - blood Questionnaires serum albumin Serum Albumin - analysis serum calcium serum potassium serum sodium Sodium Sodium - blood southeast nigeria Standard deviation Tuberculosis Tuberculosis - blood Tuberculosis - drug therapy Urine Variables Young Adult Nigeria serum potassium Tuberculosis serum sodium serum albumin serum calcium Southeast Nigeria
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Summary:	tuberculosis (TB) remains a global health issue with high morbidity and mortality rates especially in the developing countries. It is a multi-organ disease and can influence biochemical changes. This study sought to determine the influence of tuberculosis and its drug treatment on serum biochemical parameters in patients in Nigeria. it was a descriptive observational cohort study on 150 subjects whose blood samples were analyzed for serum albumin, serum sodium, and serum potassium. The subjects were grouped into 3: TB group= 50 new TB subjects not on treatment, F group= 50 TB subjects on treatment for 2/12 or more and C group= 50 non-TB control subjects. These biochemical variables were compared between the 3 groups. male/female ratio was 1: 1.5, mean age 37.1±0.92 years, and range 18-65 years. The differences in mean values of serum albumin, calcium and sodium between the three groups were significant (p<0.001), whereas that of serum potassium was not significant (p=0.056). Those patients with new case TB had a significantly lower serum sodium, serum albumin and serum calcium than the control group and those on treatment, p<0.001. There was significant positive correlation between serum albumin and serum calcium (r=0.0.420, p<0.001) as well as serum sodium (r=0.310, p<0.001) in the study population. Similarly, the correlation between serum calcium and serum sodium was positive and significant (r=0.200, p=0.014). In contrast, the correlation between serum potassium and serum albumin and that between serum potassium and serum calcium was not significant. tuberculosis with or without anti-tuberculous medications was associated with significant reduction in serum albumin, serum sodium and serum calcium in this study.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	1937-8688 1937-8688
DOI:	10.11604/pamj.2021.38.66.21707