Search Results - "Mlynarczyk, Krzysztof"
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1
Identification of Specific Effect of Chloride on the Spectral Properties and Structural Stability of Multiple Extracellular Glutamic Acid Mutants of Bacteriorhodopsin
Published in PloS one (01-09-2016)“…In the present work we combine spectroscopic, DSC and computational approaches to examine the multiple extracellular Glu mutants E204Q/E194Q, E204Q/E194Q/E9Q…”
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Feasibility of Implementation of a "Simplified, No-X-Ray, No-Lead Apron, Two-Catheter Approach" for Ablation of Supraventricular Arrhythmias in Children and Adults
Published in Journal of cardiovascular electrophysiology (01-08-2014)“…Simplified, No‐X‐Ray Catheter Ablation of SVT Introduction Although the “near‐zero‐X‐Ray” or “No‐X‐Ray” catheter ablation (CA) approach has been reported for…”
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Structural investigation of the C-terminal catalytic fragment of presenilin 1
Published in Proceedings of the National Academy of Sciences - PNAS (25-05-2010)“…The γ-secretase complex has a decisive role in the development of Alzheimer's disease, in that it cleaves a precursor to create the amyloid β peptide whose…”
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4
A patient with posterior cortical atrophy possesses a novel mutation in the presenilin 1 gene
Published in PloS one (12-04-2013)“…Posterior cortical atrophy is a dementia syndrome with symptoms of cortical visual dysfunction, associated with amyloid plaques and neurofibrillary tangles…”
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5
Conformational Changes and Unfolding of β-Amyloid Substrates in the Active Site of γ-Secretase
Published in International journal of molecular sciences (22-02-2024)“…Alzheimer's disease (AD) is the leading cause of dementia and is characterized by a presence of amyloid plaques, composed mostly of the amyloid-β (Aβ)…”
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COGRIMEN: Coarse-Grained Method for Modeling of Membrane Proteins in Implicit Environments
Published in Journal of chemical theory and computation (13-09-2022)“…The presented methodology is based on coarse-grained representation of biomolecules in implicit environments and is designed for the molecular dynamics…”
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Effectiveness, safety, and long-term outcomes of non-powered mechanical sheaths for transvenous lead extraction
Published in Europace (London, England) (01-08-2018)“…Abstract Aims To analyse the effectiveness, safety and long-term outcomes of conventional non-powered mechanical systems for transvenous lead extraction (TLE)…”
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Self-analysis of repeat proteins reveals evolutionarily conserved patterns
Published in BMC bioinformatics (07-05-2020)“…Protein repeats can confound sequence analyses because the repetitiveness of their amino acid sequences lead to difficulties in identifying whether similar…”
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The Role of Cholesterol in Amyloidogenic Substrate Binding to the γ-Secretase Complex
Published in Biomolecules (Basel, Switzerland) (24-06-2021)“…Alzheimer’s disease is the most common progressive neurodegenerative disorder and is characterized by the presence of amyloid β (Aβ) plaques in the brain. The…”
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WaterSpy: A High Sensitivity, Portable Photonic Device for Pervasive Water Quality Analysis
Published in Sensors (Basel, Switzerland) (21-12-2018)“…In this paper, we present WaterSpy, a project developing an innovative, compact, cost-effective photonic device for pervasive water quality sensing, operating…”
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Amyloid β‑Peptide 25–35 Self-Assembly and Its Inhibition: A Model Undecapeptide System to Gain Atomistic and Secondary Structure Details of the Alzheimer’s Disease Process and Treatment
Published in ACS chemical neuroscience (21-11-2012)“…Combined results of theoretical molecular dynamic simulations and in vitro spectroscopic (circular dichroism and fluorescence) studies are presented, providing…”
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Pacemaker lead extraction and recapture of venous access: technical problems arising from extensive venous obstruction
Published in Cardiology journal (2012)“…We report the case of the extraction of 18 year-old leads in a patient with a DDD pacemaker, and chronic obstruction of the left subclavian and innominate…”
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The effect of triple glutamic mutations E9Q/E194Q/E204Q on the structural stability of bacteriorhodopsin
Published in The FEBS journal (01-02-2014)“…In the present study, we report on the structural features of the bacteriorhodopsin triple mutant E9Q/E194Q/E204Q (3Glu) of bacteriorhodopsin by combining…”
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14
The Role of Electrostatic Interactions in IFIT5-RNA Complexes Predicted by the UBDB+EPMM Method
Published in The journal of physical chemistry. B (17-11-2022)“…Electrostatic energy has a significant contribution to intermolecular interaction energy, especially in biological systems. Unfortunately, precise quantum…”
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Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges
Published in Structure (London) (05-08-2014)“…Despite tremendous successes of GPCR crystallography, the receptors with available structures represent only a small fraction of human GPCRs. An important role…”
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A Patient with Posterior Cortical Atrophy Possesses a Novel Mutation in the Presenilin 1 Gene. e61074
Published in PloS one (01-04-2013)“…Posterior cortical atrophy is a dementia syndrome with symptoms of cortical visual dysfunction, associated with amyloid plaques and neurofibrillary tangles…”
Get full text
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