Search Results - "Mlakar, Logan"

Syndecan-2 is a novel target of insulin-like growth factor binding protein-3 and is over-expressed in fibrosis by Ruiz, Ximena D, Mlakar, Logan R, Yamaguchi, Yukie, Su, Yunyun, Larregina, Adriana T, Pilewski, Joseph M, Feghali-Bostwick, Carol A

“…Extracellular matrix deposition and tissue scarring characterize the process of fibrosis. Transforming growth factor beta (TGFβ) and Insulin-like growth factor…”
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Optimization of a murine and human tissue model to recapitulate dermal and pulmonary features of systemic sclerosis by Watanabe, Tomoya, Nishimoto, Tetsuya, Mlakar, Logan, Heywood, Jonathan, Malaab, Maya, Hoffman, Stanley, Feghali-Bostwick, Carol

“…The murine bleomycin (BLM)-induced fibrosis model is the most widely used in systemic sclerosis (SSc) studies. It has been reported that systemic delivery of…”
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Interferon-gamma inducible protein-10 as a potential biomarker in localized scleroderma by Magee, Kelsey E, Kelsey, Christina E, Kurzinski, Katherine L, Ho, Jonhan, Mlakar, Logan R, Feghali-Bostwick, Carol A, Torok, Kathryn S

“…The purpose of this study was to evaluate the presence and levels of interferon-gamma inducible protein-10 (IP-10) in the plasma and skin of pediatric…”
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A Human Skin Model Recapitulates Systemic Sclerosis Dermal Fibrosis and Identifies COL22A1 as a TGFβ Early Response Gene that Mediates Fibroblast to Myofibroblast Transition by Watanabe, Tomoya, Baker Frost, DeAnna, Mlakar, Logan, Heywood, Jonathan, da Silveira, Willian A, Hardiman, Gary, Feghali-Bostwick, Carol

“…Systemic sclerosis (SSc) is a complex multi-system autoimmune disease characterized by immune dysregulation, vasculopathy, and organ fibrosis. Skin fibrosis…”
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E4 engages uPAR and enolase-1 and activates urokinase to exert antifibrotic effects by Sharma, Shailza, Watanabe, Tomoya, Nishimoto, Tetsuya, Takihara, Takahisa, Mlakar, Logan, Nguyen, Xinh-Xinh, Sanderson, Matthew, Su, Yunyun, Chambers, Roger A, Feghali-Bostwick, Carol

“…Fibroproliferative disorders such as systemic sclerosis (SSc) have no effective therapies and result in significant morbidity and mortality. We recently…”
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Ameliorating Fibrosis in Murine and Human Tissues with END55, an Endostatin-Derived Fusion Protein Made in Plants by Mlakar, Logan, Garrett, Sara M, Watanabe, Tomoya, Sanderson, Matthew, Nishimoto, Tetsuya, Heywood, Jonathan, Helke, Kristi L, Pilewski, Joseph M, Herzog, Erica L, Feghali-Bostwick, Carol

“…Organ fibrosis, particularly of the lungs, causes significant morbidity and mortality. Effective treatments are needed to reduce the health burden. A fragment…”
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2027 The role of lysyl oxidase in systemic sclerosis-associated lung fibrosis by Nguyen, Xinh-Xinh, Nishimoto, Tetsuya, Takihara, Takahisa, Mlakar, Logan, Riemer, Ellen, Heywood, Jonathan, Bradshaw, Amy, Feghali-Bostwick, Carol

“…OBJECTIVES/SPECIFIC AIMS: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology characterized by progressive fibrosis of the skin and…”
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Lysyl oxidase directly contributes to extracellular matrix production and fibrosis in systemic sclerosis by Nguyen, Xinh-Xinh, Nishimoto, Tetsuya, Takihara, Takahisa, Mlakar, Logan, Bradshaw, Amy D, Feghali-Bostwick, Carol

“…Pulmonary fibrosis is one of the important causes of morbidity and mortality in fibroproliferative disorders such as systemic sclerosis (SSc) and idiopathic…”
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An endostatin-derived peptide orally exerts anti-fibrotic activity in a murine pulmonary fibrosis model by Nishimoto, Tetsuya, Mlakar, Logan, Takihara, Takahisa, Feghali-Bostwick, Carol

“…Pulmonary fibrosis causes high morbidity and mortality in affected individuals. Recently, we showed that parenteral or intratracheal administration of a…”
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The Role of Vascular Endothelial Growth Factor in Mechanically Stimulated Muscle Derived Stem Cell Repair by Beckman, Sarah, Mlakar, Logan, Huard, Johnny

“…Abstract only We have previously shown that muscle‐derived stem cells (MDSCs) are significantly better than myoblasts at maintaining cardiac function after…”
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Oxetanyl Sulfoxide MMS-350 Ameliorates Pulmonary Fibrosis In Vitro, In Vivo, and Ex Vivo by Mlakar, Logan, Lane, Jessica, Takihara, Takahisa, Lim, Chaemin, Sprachman, Melissa M, Lloyd, Kayla R, Wipf, Peter, Feghali-Bostwick, Carol

“…Fibrosis is a common feature of several diseases, involves different organs, and results in significant morbidity and mortality. There are currently no…”
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Beneficial Effect of Mechanical Stimulation on the Regenerative Potential of Muscle-Derived Stem Cells Is Lost by Inhibiting Vascular Endothelial Growth Factor by Beckman, Sarah A, Chen, William C.W, Tang, Ying, Proto, Jonathan D, Mlakar, Logan, Wang, Bing, Huard, Johnny

“…OBJECTIVE—We previously reported that mechanical stimulation increased the effectiveness of muscle-derived stem cells (MDSCs) for tissue repair. The objective…”
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The cardiac regenerative potential of myoblasts remains limited despite improving their survival via antioxidant treatment by Beckman, Sarah A, Sekiya, Naosumi, Chen, William C W, Mlakar, Logan, Tobita, Kimimassa, Huard, Johnny

“…Since myoblasts have been limited by poor cell survival after cellular myoplasty, the major goal of the current study was to determine whether improving…”
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