Search Results - "Mizutani, Kiyohito"

Nectin spot: a novel type of nectin-mediated cell adhesion apparatus by Mizutani, Kiyohito, Takai, Yoshimi

“…Nectins are Ca(2+)-independent immunoglobulin (Ig) superfamily cell adhesion molecules constituting a family with four members, all of which have three Ig-like…”
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Nectin-2 in general and in the brain by Mizutani, Kiyohito, Miyata, Muneaki, Shiotani, Hajime, Kameyama, Takeshi, Takai, Yoshimi

“…Nectins are immunoglobulin-like cell adhesion molecules constituting a family with four members, nectin-1, nectin-2, nectin-3, and nectin-4. In the brain,…”
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Nectins and Nectin-like molecules in synapse formation and involvement in neurological diseases by Mizutani, Kiyohito, Miyata, Muneaki, Shiotani, Hajime, Kameyama, Takeshi, Takai, Yoshimi

“…Synapses are interneuronal junctions which form neuronal networks and play roles in a variety of functions, including learning and memory. Two types of…”
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Nectin-4 and p95-ErbB2 cooperatively regulate Hippo signaling-dependent SOX2 gene expression, enhancing anchorage-independent T47D cell proliferation by Kedashiro, Shin, Kameyama, Takeshi, Mizutani, Kiyohito, Takai, Yoshimi

“…Nectin-4, upregulated in various cancer cells, cis -interacts with ErbB2 and its trastuzumab-resistant splice variants, p95-ErbB2 and ErbB2∆Ex16, enhancing DNA…”
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A novel role for PRL in regulating epithelial cell density by inducing apoptosis at confluence by Lohani, Sweksha, Funato, Yosuke, Akieda, Yuki, Mizutani, Kiyohito, Takai, Yoshimi, Ishitani, Tohru, Miki, Hiroaki

“…Maintaining proper epithelial cell density is essential for the survival of multicellular organisms. Although regulation of cell density through apoptosis is…”
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Requirement of the F‐actin‐binding activity of l‐afadin for enhancing the formation of adherens and tight junctions by Sakakibara, Shotaro, Maruo, Tomohiko, Miyata, Muneaki, Mizutani, Kiyohito, Takai, Yoshimi

“…The apical junctional complex consists of adherens junctions (AJs) and tight junctions (TJs) in polarized epithelial cells, which are attached to each other to…”
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Roles of the third Ig‐like domain of Necl‐5/PVR and the fifth Ig‐like domain of the PDGF receptor in its signaling by Ueda, Yuki, Kedashiro, Shin, Maruoka, Masahiro, Mizutani, Kiyohito, Takai, Yoshimi

“…The immunoglobulin (Ig)‐like cell adhesion molecule nectin‐like molecule (Necl)‐5/poliovirus receptor is up‐regulated in many types of cancer cells and…”
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The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation by Yamana, Shota, Tokiyama, Amina, Mizutani, Kiyohito, Hirata, Ken-ichi, Takai, Yoshimi, Rikitake, Yoshiyuki

“…Contact inhibition of cell movement and proliferation is critical for proper organogenesis and tissue remodeling. We show here a novel regulatory mechanism for…”
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Downregulation of CXCR4 in Metastasized Breast Cancer Cells and Implication in Their Dormancy by Nobutani, Kentaro, Shimono, Yohei, Mizutani, Kiyohito, Ueda, Yuki, Suzuki, Toshihiro, Kitayama, Midori, Minami, Akihiro, Momose, Kenji, Miyawaki, Kohta, Akashi, Koichi, Azuma, Takeshi, Takai, Yoshimi

“…Our understanding of the mechanism of cancer dormancy is emerging, but the underlying mechanisms are not fully understood. Here we analyzed mouse xenograft…”
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Absence of primary cilia in cell cycle‐arrested human breast cancer cells by Nobutani, Kentaro, Shimono, Yohei, Yoshida, Midori, Mizutani, Kiyohito, Minami, Akihiro, Kono, Seishi, Mukohara, Toru, Yamasaki, Takashi, Itoh, Tomoo, Takao, Shintaro, Minami, Hironobu, Azuma, Takeshi, Takai, Yoshimi

“…Previous studies using cultured cells showed that primary cilia are present in quiescent cells, but are absent in proliferating cells. We studied here the…”
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Identification of Sox2 and NeuN Double-Positive Cells in the Mouse Hypothalamic Arcuate Nucleus and Their Reduction in Number With Aging by Sugiura, Ayumu, Shimizu, Tatsuhiro, Kameyama, Takeshi, Maruo, Tomohiko, Kedashiro, Shin, Miyata, Muneaki, Mizutani, Kiyohito, Takai, Yoshimi

“…The hypothalamus plays a central role in homeostasis and aging. The hypothalamic arcuate nucleus (ARC) controls homeostasis of food intake and energy…”
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Heterogeneity of perivascular astrocyte endfeet depending on vascular regions in the mouse brain by Kameyama, Takeshi, Miyata, Muneaki, Shiotani, Hajime, Adachi, Jun, Kakuta, Soichiro, Uchiyama, Yasuo, Mizutani, Kiyohito, Takai, Yoshimi

“…Astrocytes interact with not only synapses but also brain blood vessels through perivascular astrocyte endfeet (PV-AEF) to form the neurovascular unit (NVU)…”
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Suppression of the TGF‐β1‐induced protein expression of SNAI1 and N‐cadherin by miR‐199a by Suzuki, Toshihiro, Mizutani, Kiyohito, Minami, Akihiro, Nobutani, Kentaro, Kurita, Souichi, Nagino, Masato, Shimono, Yohei, Takai, Yoshimi

“…MicroRNA miR‐199a is clustered with miR‐214 on chromosome 1 and its expression is up‐regulated by various factors that are associated with…”
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Necl-1/CADM3 regulates cone synapse formation in the mouse retina by Kawashima, Rumi, Matsushita, Kenji, Mandai, Kenji, Sugita, Yuko, Maruo, Tomohiko, Mizutani, Kiyohito, Midoh, Yoshihiro, Oguchi, Akiko, Murakawa, Yasuhiro, Kuniyoshi, Kazuki, Sato, Ryohei, Furukawa, Takahisa, Nishida, Kohji, Takai, Yoshimi

“…In vertebrates, retinal neural circuitry for visual perception is organized in specific layers. The outer plexiform layer is the first synaptic region in the…”
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Genetic ablation of afadin causes mislocalization and deformation of Paneth cells in the mouse small intestinal epithelium by Tanaka-Okamoto, Miki, Itoh, Yu, Miyoshi, Jun, Mizoguchi, Akira, Mizutani, Kiyohito, Takai, Yoshimi, Inoue, Masahiro

“…Afadin is an actin filament-binding protein that acts cooperatively in cell adhesion with the cell adhesion molecule nectin, and in directional cell movement…”
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miR‐214 and hypoxia down‐regulate Necl‐2/CADM1 and enhance ErbB2/ErbB3 signaling by Momose, Kenji, Minami, Akihiro, Shimono, Yohei, Mizutani, Kiyohito, Nobutani, Kentaro, Azuma, Takeshi, Takai, Yoshimi

“…Necl‐2/CADM1 is down‐regulated by the promoter hypermethylation and/or the loss of heterozygosity at chromosome 11q23.2 in many types of cancers and serves as…”
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Increased Insulin Action in SKIP Heterozygous Knockout Mice by Ijuin, Takeshi, Yu, Y. Eugene, Mizutani, Kiyohito, Pao, Annie, Tateya, Sanshiro, Tamori, Yoshikazu, Bradley, Allan, Takenawa, Tadaomi

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet-derived growth factor by Miyata, Muneaki, Ogita, Hisakazu, Komura, Hitomi, Nakata, Shinsuke, Okamoto, Ryoko, Ozaki, Misa, Majima, Takashi, Matsuzawa, Naomi, Kawano, Satoshi, Minami, Akihiro, Waseda, Masumi, Fujita, Naoyuki, Mizutani, Kiyohito, Rikitake, Yoshiyuki, Takai, Yoshimi

“…Afadin is an actin-filament-binding protein that binds to nectin, an immunoglobulin-like cell-cell adhesion molecule, and plays an important role in the…”
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Necl‐5/PVR enhances PDGF‐induced attraction of growing microtubules to the plasma membrane of the leading edge of moving NIH3T3 cells by Minami, Akihiro, Mizutani, Kiyohito, Waseda, Masazumi, Kajita, Mihoko, Miyata, Muneaki, Ikeda, Wataru, Takai, Yoshimi

“…Microtubules (MTs) search for and grow toward the leading edge of moving cells, followed by their stabilization at a specific structure at the rear site of the…”
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WAVE3 Functions as a Negative Regulator of LDOC1 by Mizutani, Kiyohito, Koike, Daisuke, Suetsugu, Shiro, Takenawa, Tadaomi

“…WAVE3 belongs to the Wiskott-Aldrich syndrome protein family that mediates actin reorganization through activation of the Arp2/3 complex. However, the…”
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