Search Results - "Mizuno‐Yasuhira, Akiko"

Prediction of a clinically effective dose of THY1773, a novel V1B receptor antagonist, based on preclinical data by Inatani, Shoko, Mizuno‐Yasuhira, Akiko, Kamiya, Makoto, Nishino, Izumi, Sabia, Helene D., Endo, Hiromi

“…THY1773 is a novel arginine vasopressin 1B (V1B) receptor antagonist that is under development as an oral drug for the treatment of major depressive disorder…”
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Preclinical metabolism and the disposition of vornorexant/TS‐142, a novel dual orexin 1/2 receptor antagonist for the treatment of insomnia by Konno, Yoshihiro, Kamigaso, Shunsuke, Toki, Hidetoh, Terasaka, Shuichi, Hikichi, Hirohiko, Endo, Hiromi, Yamaguchi, Jun‐Ichi, Mizuno‐Yasuhira, Akiko

“…We investigated the metabolism and disposition of vornorexant, a novel dual orexin receptor antagonist, in rats and dogs, and clarified in vitro metabolite…”
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A rapid and sensitive chiral LC–MS/MS method for the determination of ketamine and norketamine in mouse plasma, brain and cerebrospinal fluid applicable to the stereoselective pharmacokinetic study of ketamine by Toki, Hidetoh, Ichikawa, Takuya, Mizuno-Yasuhira, Akiko, Yamaguchi, Jun-ichi

“…•A chiral LC–MS/MS assay for ketamine and norketamine was developed and validated.•Analytical run time was just 5min per injection.•High sensitivity allowed…”
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Prediction of a clinically effective dose of THY1773, a novel V 1B receptor antagonist, based on preclinical data by Inatani, Shoko, Mizuno-Yasuhira, Akiko, Kamiya, Makoto, Nishino, Izumi, Sabia, Helene D, Endo, Hiromi

“…THY1773 is a novel arginine vasopressin 1B (V ) receptor antagonist that is under development as an oral drug for the treatment of major depressive disorder…”
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Lack of deuterium isotope effects in the antidepressant effects of (R)-ketamine in a chronic social defeat stress model by Zhang, Kai, Toki, Hidetoh, Fujita, Yuko, Ma, Min, Chang, Lijia, Qu, Youge, Harada, Shingo, Nemoto, Tetsuhiro, Mizuno-Yasuhira, Akiko, Yamaguchi, Jun-ichi, Chaki, Shigeyuki, Hashimoto, Kenji

“…Rationale ( R,S )-ketamine, an N -methyl-D-aspartate receptor (NMDAR) antagonist, exhibits rapid and long-lasting antidepressant effects and anti-suicidal…”
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Using the drug repositioning approach to develop a novel therapy, tipepidine hibenzate sustained-release tablet (TS-141), for children and adolescents with attention-deficit/hyperactivity disorder by Saito, Takuya, Yamashita, Yushiro, Tomoda, Akemi, Okada, Takashi, Umeuchi, Hideo, Iwamori, Saki, Shinoda, Satoru, Mizuno-Yasuhira, Akiko, Urano, Hidetoshi, Nishino, Izumi, Saito, Kazuhiko

“…Asverin® (tipepidine hibenzate) has been used as an antitussive for > 50 years in Japan. Studies revealed that tipepidine modulates monoamine levels, by…”
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Metabolite profiling and enzyme reaction phenotyping of luseogliflozin, a sodium-glucose cotransporter 2 inhibitor, in humans by Miyata, Atsunori, Hasegawa, Masatoshi, Hachiuma, Kenji, Mori, Haruyuki, Horiuchi, Nobuko, Mizuno-Yasuhira, Akiko, Chino, Yukihiro, Jingu, Shigeji, Sakai, Soichi, Samukawa, Yoshishige, Nakai, Yasuhiro, Yamaguchi, Jun-ichi

“…1. To understand the clearance mechanism of luseogliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, we investigated its human metabolite profile…”
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A sensitive and selective method for the quantitative analysis of miglitol in rat plasma using unique solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry by Mizuno-Yasuhira, Akiko, Kinoshita, Kohnosuke, Jingu, Shigeji, Yamaguchi, Jun-ichi

“…ABSTRACT A sensitive, selective and robust liquid chromatography–tandem mass spectrometry (LC‐MS/MS) method was developed for the quantification of miglitol in…”
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A Strategy for assessing potential drug-drug interactions of a concomitant agent against a drug absorbed via an intestinal transporter in humans by Mizuno-Yasuhira, Akiko, Nakai, Yasuhiro, Gunji, Emi, Uchida, Saeko, Takahashi, Teisuke, Kinoshita, Kohnosuke, Jingu, Shigeji, Sakai, Soichi, Samukawa, Yoshishige, Yamaguchi, Jun-Ichi

“…A strategy for assessing potential drug-drug interactions (DDIs) based on a simulated intestinal concentration is described. The proposed prediction method was…”
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(2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice by Yamaguchi, Jun-Ichi, Toki, Hidetoh, Qu, Youge, Yang, Chun, Koike, Hiroyuki, Hashimoto, Kenji, Mizuno-Yasuhira, Akiko, Chaki, Shigeyuki

“…(R,S)-Ketamine has rapid and sustained antidepressant effects in depressed patients. Although the metabolism of (R,S)-ketamine to (2 R,6 R)-hydroxynorketamine…”
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Chiral LC-MS/MS method for the simultaneous determination of (R,S)-ketamine, (R,S)-norketamine, and (2R,6R;2S,6S)-hydroxynorketamine in mouse plasma and brain by Toki, Hidetoh, Yamaguchi, Jun-ichi, Mizuno-Yasuhira, Akiko, Endo, Hiromi

“…A convenient LC-MS/MS assay method to simultaneously and sensitively determine (R,S)-ketamine (Ket), (R,S)-norketamine (NK), and…”
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Elucidation of clearance mechanism of TP0463518, a novel hypoxia-inducible factor prolyl hydroxylase inhibitor: does a species difference in excretion routes exist between humans and animals? by Takano, Hiroki, Mizuno-Yasuhira, Akiko, Yamaguchi, Jun-ichi, Endo, Hiromi

“…1. TP0463518, a novel hypoxia-inducible factor prolyl hydroxylase inhibitor, is reportedly excreted predominantly through urinary excretion in an unchanged…”
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No Sex-Specific Differences in the Acute Antidepressant Actions of (R)-Ketamine in an Inflammation Model by Chang, Lijia, Toki, Hidetoh, Qu, Youge, Fujita, Yuko, Mizuno-Yasuhira, Akiko, Yamaguchi, Jun-Ichi, Chaki, Shigeyuki, Hashimoto, Kenji

“…Although previous reports suggest sex-specific differences in the antidepressant actions of (R,S)-ketamine, these differences in the antidepressant actions of…”
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Development and validation of a liquid chromatography–tandem mass spectrometric method for the quantification of 5-thio-d-glucose in rat and human plasma by Mizuno-Yasuhira, Akiko, Jingu, Shigeji, Okuyama, Shigeru

“…► An LC–MS/MS method for the analysis of 5-thio-d-glucose in plasma was developed. ► The validated quantitation range was from 10 to 3000ng/mL. ► This is the…”
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