Search Results - "Mizuno, Toshiki"

Alterations of the gut ecological and functional microenvironment in different stages of multiple sclerosis by Takewaki, Daiki, Suda, Wataru, Sato, Wakiro, Takayasu, Lena, Kumar, Naveen, Kimura, Kimitoshi, Kaga, Naoko, Mizuno, Toshiki, Miyake, Sachiko, Hattori, Masahira, Yamamura, Takashi

“…Multiple sclerosis (MS), an autoimmune disease of the central nervous system, generally starts as the relapsing remitting form (RRMS), but often shifts into…”
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Genotype-phenotype correlations and effect of mutation location in Japanese CADASIL patients by Mukai, Mao, Mizuta, Ikuko, Watanabe-Hosomi, Akiko, Koizumi, Takashi, Matsuura, Jun, Hamano, Ai, Tomimoto, Hidekazu, Mizuno, Toshiki

“…Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary cerebral small vessel disease caused by…”
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Clinical and radiological characteristics of older‐adult‐onset Alexander disease by Yoshida, Tomokatsu, Mizuta, Ikuko, Yasuda, Rei, Mizuno, Toshiki

“…Background Alexander disease (ALXDRD) affects a wide range of ages from infancy to adulthood. However, only a few cases involving patients with older‐adult…”
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Risk factors for neuropsychiatric symptoms in patients with Parkinson's disease during COVID-19 pandemic in Japan by Kitani-Morii, Fukiko, Kasai, Takashi, Horiguchi, Go, Teramukai, Satoshi, Ohmichi, Takuma, Shinomoto, Makiko, Fujino, Yuzo, Mizuno, Toshiki

“…The worsening of neuropsychiatric symptoms such as depression, anxiety, and insomnia in patients with Parkinson's disease (PD) has been a concern during the…”
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Vessel-Associated Immune Cells in Cerebrovascular Diseases: From Perivascular Macrophages to Vessel-Associated Microglia by Koizumi, Takashi, Kerkhofs, Danielle, Mizuno, Toshiki, Steinbusch, Harry W M, Foulquier, Sébastien

“…Cerebral small vessels feed and protect the brain parenchyma thanks to the unique features of the blood-brain barrier. Cerebrovascular dysfunction is therefore…”
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Clinical and Genetic Aspects of CADASIL by Mizuno, Toshiki, Mizuta, Ikuko, Watanabe-Hosomi, Akiko, Mukai, Mao, Koizumi, Takashi

“…Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary cerebral small vessel disease caused by…”
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A muscle ultrasound score in the diagnosis of amyotrophic lateral sclerosis by Tsuji, Yukiko, Noto, Yu-ichi, Shiga, Kensuke, Teramukai, Satoshi, Nakagawa, Masanori, Mizuno, Toshiki

“…Abstract Objective The aims of this study are to elucidate the frequencies and distribution of fasciculations using muscle ultrasound in patients with…”
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Difference in distribution of fasciculations between multifocal motor neuropathy and amyotrophic lateral sclerosis by Tsuji, Yukiko, Noto, Yu-ichi, Kitaoji, Takamasa, Kojima, Yuta, Mizuno, Toshiki

“…•MMN and ALS patients were compared regarding their distribution of fasciculations.•Fasciculations were detected extensively even in the limbs of MMN…”
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Drosophila as a Model for Microbiota Studies of Neurodegeneration by Kitani-Morii, Fukiko, Friedland, Robert P, Yoshida, Hideki, Mizuno, Toshiki

“…Accumulating evidence show that the gut microbiota is deeply involved not only in host nutrient metabolism but also in immune function, endocrine regulation,…”
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Serum leucine-rich α2 glycoprotein as a potential biomarker for systemic inflammation in Parkinson's disease by Ohmichi, Takuma, Kasai, Takashi, Shinomoto, Makiko, Kitani-Morii, Fukiko, Fujino, Yuzo, Menjo, Kanako, Mizuno, Toshiki

“…There is ample epidemiological and animal-model evidence suggesting that intestinal inflammation is associated with the development of Parkinson's disease…”
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Amyotrophic lateral sclerosis: Correlations between fluid biomarkers of NfL, TDP-43, and tau, and clinical characteristics by Kojima, Yuta, Kasai, Takashi, Noto, Yu-Ichi, Ohmichi, Takuma, Tatebe, Harutsugu, Kitaoji, Takamasa, Tsuji, Yukiko, Kitani-Morii, Fukiko, Shinomoto, Makiko, Allsop, David, Teramukai, Satoshi, Mizuno, Toshiki, Tokuda, Takahiko

“…We previously reported the diagnostic and prognostic performance of neurofilament light chain (NfL), TAR DNA-binding protein 43 (TDP-43), and total tau (t-tau)…”
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Serum Levels of Coenzyme Q10 in Patients with Multiple System Atrophy by Kasai, Takashi, Tokuda, Takahiko, Ohmichi, Takuma, Ishii, Ryotaro, Tatebe, Harutsugu, Nakagawa, Masanori, Mizuno, Toshiki

“…The COQ2 gene encodes an essential enzyme for biogenesis, coenzyme Q10 (CoQ10). Recessive mutations in this gene have recently been identified in families with…”
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Lysosomal enzyme cathepsin B enhances the aggregate forming activity of exogenous α-synuclein fibrils by Tsujimura, Atsushi, Taguchi, Katsutoshi, Watanabe, Yoshihisa, Tatebe, Harutsugu, Tokuda, Takahiko, Mizuno, Toshiki, Tanaka, Masaki

“…Abstract The formation of intracellular aggregates containing α-synuclein (α-Syn) is one of the key steps in the progression of Parkinson's disease and…”
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Quantitative assessment of muscle echogenicity in Charcot-Marie-Tooth disease type 1A by automatic thresholding methods by Kitaoji, Takamasa, Noto, Yu-ichi, Kojima, Yuta, Tsuji, Yukiko, Mizuno, Toshiki, Nakagawa, Masanori

“…•Quantitative muscle ultrasound by automatic thresholding methods was applied to muscle echogenicity evaluation.•Automatic thresholding methods can detect the…”
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Zinc Administration Favorably Affects Prophylactic Therapy-refractory Migraine Attacks: A Case Series by Fukazawa, Ryosuke, Ishii, Ryotaro, Higashimoto, Yuki, Hanya, Misaki, Shimizu, Yuki, Shinomoto, Makiko, Fujii, Akihiro, Mizuno, Toshiki

“…Notably, certain nutrients are effective in preventing migraine. Nonetheless, zinc replacement therapy for migraine treatment has yet to be explored. We herein…”
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Sonographic Nerve Enlargement in a Patient with Sarcoidosis by Kitaoji, Takamasa, Tsuji, Yukiko, Noto, Yu-ichi, Ashida, Shinji, Tanaka, Akihiro, Mizuno, Toshiki

“…We herein report a 73-year-old woman case with sarcoid neuropathy showing nerve enlargement assessed by nerve ultrasound both before and after treatment. The…”
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Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patients by Shinomoto, Makiko, Kasai, Takashi, Tatebe, Harutsugu, Kondo, Masaki, Ohmichi, Takuma, Morimoto, Masafumi, Chiyonobu, Tomohiro, Terada, Naoto, Allsop, David, Yokota, Isao, Mizuno, Toshiki, Tokuda, Takahiko

“…People with Down syndrome (DS) are at high risk of developing Alzheimer disease (AD) with aging. The diagnosis and treatment trials are hampered by a lack of…”
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Increased levels of plasma total tau in adult Down syndrome by Kasai, Takashi, Tatebe, Harutsugu, Kondo, Masaki, Ishii, Ryotaro, Ohmichi, Takuma, Yeung, Wing Tung Esther, Morimoto, Masafumi, Chiyonobu, Tomohiro, Terada, Naoto, Allsop, David, Nakagawa, Masanori, Mizuno, Toshiki, Tokuda, Takahiko

“…Down syndrome (DS) is the most prevalent chromosomal abnormality. Early-onset dementia with the pathology of Alzheimer's disease (AD) frequently develops in…”
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Signaling via toll-like receptor 4 and CD40 in B cells plays a regulatory role in the pathogenesis of multiple sclerosis through interleukin-10 production by Okada, Yoichiro, Ochi, Hirofumi, Fujii, Chihiro, Hashi, Yuichiro, Hamatani, Mio, Ashida, Shinji, Kawamura, Kazuyuki, Kusaka, Hirofumi, Matsumoto, Sadayuki, Nakagawa, Masanori, Mizuno, Toshiki, Takahashi, Ryosuke, Kondo, Takayuki

“…B cells play an important role in the development of multiple sclerosis (MS), but can also exhibit regulatory functions through IL-10 production. Toll-like…”
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Contrasting echogenicity in flexor digitorum profundus-flexor carpi ulnaris: A diagnostic ultrasound pattern in sporadic inclusion body myositis by Noto, Yu-Ichi, Shiga, Kensuke, Tsuji, Yukiko, Kondo, Masaki, Tokuda, Takahiko, Mizuno, Toshiki, Nakagawa, Masanori

“…ABSTRACT Introduction: In this study we aimed to clarify whether muscle ultrasound (US) of the forearm can be used to differentiate between patients with…”
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